DegronMD

Uniprot ID: Q08495

Source protein: Dematin

Source gene: DMTN

Class: DEG_SPOP_SBC_1

Location: 88:92

E3 ligase: SPOP

DEGRON score: 0.8879

ASA_SCORE: 90.26

COIL: 0.9528

CONS_SCORE: 0.6895

DSS_SCORE: 0.6624

HELIX: 0.0134

FCONS_SCORE: 1.0426

RIG_SCORE: 0.5122

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R84C	TCGA-12-0775	GBM	TCGA	PKSTS	DEG_SPOP_SBC_1	0.2222
p.R84C	TCGA-EO-A22U	UCEC	TCGA	PKSTS	DEG_SPOP_SBC_1	0.2222
p.R84C	DO14133	GBM	ICGC	PKSTS	DEG_SPOP_SBC_1	0.2222
p.R84C	DO43755	UCEC	ICGC	PKSTS	DEG_SPOP_SBC_1	0.2222
p.S92P	TCGA-B0-4710	KIRC	TCGA	PKSTS	DEG_SPOP_SBC_1	0.7863
p.S92P	DO20633	KIRC	ICGC	PKSTS	DEG_SPOP_SBC_1	0.7863
p.S85L	TCGA-EL-A3CT	THCA	TCGA	PKSTS	DEG_SPOP_SBC_1	0.6944
p.S85L	DO48113	THCA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.6944
p.R80C	TCGA-LN-A7HW	ESCA	TCGA	PKSTS	DEG_SPOP_SBC_1	0.1111
p.R80C	TCGA-RS-A6TP	HNSC	TCGA	PKSTS	DEG_SPOP_SBC_1	0.1111
p.R80C	DO219062	HNSC	ICGC	PKSTS	DEG_SPOP_SBC_1	0.1111
p.S92F	TCGA-VQ-A91K	STAD	TCGA	PKSTS	DEG_SPOP_SBC_1	0.9093
p.S92F	DO51785	STAD	ICGC	PKSTS	DEG_SPOP_SBC_1	0.9093
p.R84H	DO233261	GACA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.2222
p.V99L	DO229006	LICA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.1389
p.R82L	DO227557	ORCA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.1667
p.P93R	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	PKSTS	DEG_SPOP_SBC_1	0.3056
p.P93R	ACH-000875	Lung Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	0.3056
p.P93R	NCI-H2347	lung	COSMIC	PKSTS	DEG_SPOP_SBC_1	0.3056
p.T83I	ACH-000967	Colon/Colorectal Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	0.1944
p.T83I	ACH-001199	Colon/Colorectal Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	0.1944
p.T83I	SNU-C2B	large_intestine	COSMIC	PKSTS	DEG_SPOP_SBC_1	0.1944
p.S80L	Hs939-T	skin	COSMIC	PKSTS	DEG_SPOP_SBC_1	0.1111
p.T98I	SNU-C2B	large_intestine	COSMIC	PKSTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14939	Phospholipase D2	DEG_SPOP_SBC_1	583:587	PKSTS	SPOP	0.7698	More...
O43497	Voltage-dependent T-type calcium channel subunit alpha-1G	DEG_SPOP_SBC_1	1051:1055	PKSTS	SPOP	0.9183	More...
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	278:282	PKSTS	SPOP	0.8251	More...
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	861:865	PKSTS	SPOP	0.994	More...
Q08495	Dematin	DEG_SPOP_SBC_1	88:92	PKSTS	SPOP	0.8879	More...
Q14154	DAP3-binding cell death enhancer 1	DEG_SPOP_SBC_1	25:29	PKSTS	SPOP	0.9768	More...
Q5JR59	Microtubule-associated tumor suppressor candidate 2	DEG_SPOP_SBC_1	928:932	PKSTS	SPOP	0.974	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	2971:2975	PKSTS	SPOP	0.5397	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	234:238	PKSTS	SPOP	0.6925	More...
Q9H808	Transducin-like enhancer protein 6	DEG_SPOP_SBC_1	13:17	PKSTS	SPOP	0.6634	More...
Q9NW75	G patch domain-containing protein 2	DEG_SPOP_SBC_1	513:517	PKSTS	SPOP	0.8361	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons