DegronMD

Uniprot ID: Q9H808

Source protein: Transducin-like enhancer protein 6

Source gene: TLE6

Class: DEG_SPOP_SBC_1

Location: 13:17

E3 ligase: SPOP

DEGRON score: 0.6634

ASA_SCORE: 88.48

COIL: 0.933

CONS_SCORE: 0.5676

DSS_SCORE: 0.8198

HELIX: 0.0212

FCONS_SCORE: 1.0052

RIG_SCORE: 0.5156

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P12H	TCGA-AH-6549	READ	TCGA	PKSTS	DEG_SPOP_SBC_1	0.3056
p.P12H	DO37066	READ	ICGC	PKSTS	DEG_SPOP_SBC_1	0.3056
p.S3F	TCGA-AN-A046	BRCA	TCGA	PKSTS	DEG_SPOP_SBC_1	0.0556
p.S3F	DO1285	BRCA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.0556
p.S17L	TCGA-CA-6717	COAD	TCGA	PKSTS	DEG_SPOP_SBC_1	0.7667
p.S17L	DO8264	COAD	ICGC	PKSTS	DEG_SPOP_SBC_1	0.7667
p.W8C	DO228126	EOPC	ICGC	PKSTS	DEG_SPOP_SBC_1	0.1944
p.D7E	DO228126	EOPC	ICGC	PKSTS	DEG_SPOP_SBC_1	0.1667
p.K27R	DO15719	HNSC	ICGC	PKSTS	DEG_SPOP_SBC_1	0.0556
p.Q18H	DO228971	LICA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.3056
p.P12L	DO220891	MELA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.3056
p.G21R	DO46394	OV	ICGC	PKSTS	DEG_SPOP_SBC_1	0.2222
p.L9F	DO37551	SKCM	ICGC	PKSTS	DEG_SPOP_SBC_1	0.2222
p.N24K	DO229229	THCA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.1389
p.G11C	SIDM00789	Colorectal Carcinoma	GDSC	PKSTS	DEG_SPOP_SBC_1	0.2778
p.G11C	ACH-000997	Colon/Colorectal Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	0.2778
p.G11C	ACH-001061	Colon/Colorectal Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	0.2778
p.G11C	HCT-15	large_intestine	COSMIC	PKSTS	DEG_SPOP_SBC_1	0.2778
p.Q6H	SIDM00309	Mesothelioma	GDSC	PKSTS	DEG_SPOP_SBC_1	0.1389
p.Q6H	SIDM00760	Small Cell Lung Carcinoma	GDSC	PKSTS	DEG_SPOP_SBC_1	0.1389
p.S25C	ACH-000854	Myeloma	CCLE	PKSTS	DEG_SPOP_SBC_1	0.1111
p.L13S	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PKSTS	DEG_SPOP_SBC_1	0.7667
p.G14R	DOK	upper_aerodigestive_tract	COSMIC	PKSTS	DEG_SPOP_SBC_1	0.7568
p.R11W	OCI-AML3	haematopoietic_and_lymphoid_tissue	COSMIC	PKSTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14939	Phospholipase D2	DEG_SPOP_SBC_1	583:587	PKSTS	SPOP	0.7698	More...
O43497	Voltage-dependent T-type calcium channel subunit alpha-1G	DEG_SPOP_SBC_1	1051:1055	PKSTS	SPOP	0.9183	More...
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	278:282	PKSTS	SPOP	0.8251	More...
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	861:865	PKSTS	SPOP	0.994	More...
Q08495	Dematin	DEG_SPOP_SBC_1	88:92	PKSTS	SPOP	0.8879	More...
Q14154	DAP3-binding cell death enhancer 1	DEG_SPOP_SBC_1	25:29	PKSTS	SPOP	0.9768	More...
Q5JR59	Microtubule-associated tumor suppressor candidate 2	DEG_SPOP_SBC_1	928:932	PKSTS	SPOP	0.974	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	2971:2975	PKSTS	SPOP	0.5397	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	234:238	PKSTS	SPOP	0.6925	More...
Q9H808	Transducin-like enhancer protein 6	DEG_SPOP_SBC_1	13:17	PKSTS	SPOP	0.6634	More...
Q9NW75	G patch domain-containing protein 2	DEG_SPOP_SBC_1	513:517	PKSTS	SPOP	0.8361	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons