DegronMD - Q5JR59(MTUS2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A951T	TCGA-10-0930	OV	TCGA	AASTT	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1111
p.A951T	DO32113	OV	ICGC	AASTT	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1111
p.V539F	TCGA-13-0920	OV	TCGA	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation rewiring degron network	0.0833
p.V539F	DO28099	OV	ICGC	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation rewiring degron network	0.0833
p.P913T	TCGA-17-Z042	LUAD	TCGA	PASSS	DEG_SPOP_SBC_1	912:916	Mutation altering degron motif	0.7031
p.G845C	TCGA-5P-A9JZ	KIRP	TCGA	PPGY	ITCH	838:841	Mutation rewiring degron network	0.2222
p.G845C	DO223945	KIRP	ICGC	PPGY	ITCH	838:841	Mutation rewiring degron network	0.2222
p.G845V	TCGA-5P-A9JZ	KIRP	TCGA	PPGY	ITCH	838:841	Mutation rewiring degron network	0.2222
p.G845V	DO223945	KIRP	ICGC	PPGY	ITCH	838:841	Mutation rewiring degron network	0.2222
p.L540I	TCGA-A5-A2K5	UCEC	TCGA	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation rewiring degron network	0.1111
p.L540I	TCGA-QF-A5YS	UCEC	TCGA	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation rewiring degron network	0.1111
p.L540I	DO52426	UCEC	ICGC	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation rewiring degron network	0.1111
p.L540I	DO41379	UCEC	ICGC	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation rewiring degron network	0.1111
p.P561S	TCGA-AJ-A3EK	UCEC	TCGA	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation rewiring degron network	0.1389
p.P561S	DO41584	UCEC	ICGC	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation rewiring degron network	0.1389
p.G850R	TCGA-AP-A5FX	UCEC	TCGA	PPGY	ITCH	838:841	Mutation rewiring degron network	0.0833
p.G850R	DO49072	UCEC	ICGC	PPGY	ITCH	838:841	Mutation rewiring degron network	0.0833
p.G850R	ACH-000266	Pancreatic Cancer	CCLE	PPGY	ITCH	838:841	Mutation rewiring degron network	0.0833
p.R918Q	TCGA-AZ-4615	COAD	TCGA	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.2778
p.R918Q	TCGA-AZ-4615	COAD	TCGA	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.0556
p.R918Q	TCGA-EO-A22S	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.2778
p.R918Q	TCGA-EO-A22S	UCEC	TCGA	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.0556
p.R918Q	DO7977	COAD	ICGC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.2778
p.R918Q	DO7977	COAD	ICGC	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.0556
p.R918Q	DO233810	GACA	ICGC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.2778
p.R918Q	DO233810	GACA	ICGC	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.0556
p.R918Q	DO41590	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.2778
p.R918Q	DO41590	UCEC	ICGC	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.0556
p.R918L	TCGA-BF-A1Q0	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.2778
p.R918L	TCGA-BF-A1Q0	SKCM	TCGA	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.0556
p.R918L	DO47374	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.2778
p.R918L	DO47374	SKCM	ICGC	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.0556
p.A916G	TCGA-BR-6452	STAD	TCGA	PASSS	DEG_SPOP_SBC_1	912:916	Mutation altering degron motif	0.754
p.A916G	DO38404	STAD	ICGC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation altering degron motif	0.754
p.R931H	TCGA-BR-8679	STAD	TCGA	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation altering degron motif	0.8244
p.R931H	TCGA-S9-A7R1	LGG	TCGA	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation altering degron motif	0.8244
p.R931H	DO234250	ESAD	ICGC	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation altering degron motif	0.8244
p.R931H	DO51839	LGG	ICGC	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation altering degron motif	0.8244
p.R931H	DO47875	STAD	ICGC	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation altering degron motif	0.8244
p.T551N	TCGA-BS-A0UV	UCEC	TCGA	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation altering degron motif	0.7055
p.T551N	DO42793	UCEC	ICGC	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation altering degron motif	0.7055
p.R967K	TCGA-CV-7568	HNSC	TCGA	AASTT	DEG_SPOP_SBC_1	959:963	Mutation blocking phosphorylation signal	0.6667
p.R967K	DO14160	HNSC	ICGC	AASTT	DEG_SPOP_SBC_1	959:963	Mutation blocking phosphorylation signal	0.6667
p.P561L	TCGA-D3-A2JD	SKCM	TCGA	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation rewiring degron network	0.1389
p.P561L	DO37543	SKCM	ICGC	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation rewiring degron network	0.1389
p.S563G	TCGA-DF-A2KN	UCEC	TCGA	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation rewiring degron network	0.0833
p.S563G	DO223282	UCEC	ICGC	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation rewiring degron network	0.0833
p.S940F	TCGA-DF-A2KU	UCEC	TCGA	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1111
p.S940F	DO220875	MELA	ICGC	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1111
p.S940F	DO223286	UCEC	ICGC	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1111
p.T957A	TCGA-DI-A1BU	UCEC	TCGA	AASTT	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.2778
p.T957A	DO42023	UCEC	ICGC	AASTT	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.2778
p.L935I	TCGA-DK-A6AW	BLCA	TCGA	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.25
p.L935I	DO48566	BLCA	ICGC	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.25
p.A937V	TCGA-FP-A4BE	STAD	TCGA	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation blocking phosphorylation signal	0.6389
p.A937V	TCGA-W2-A7UY	PCPG	TCGA	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation blocking phosphorylation signal	0.6389
p.A937V	DO891	BOCA	ICGC	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation blocking phosphorylation signal	0.6389
p.A937V	DO229364	BTCA	ICGC	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation blocking phosphorylation signal	0.6389
p.A937V	DO48016	STAD	ICGC	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation blocking phosphorylation signal	0.6389
p.T555A	TCGA-G4-6588	COAD	TCGA	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation rewiring degron network	0.3056
p.T555A	DO10140	COAD	ICGC	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation rewiring degron network	0.3056
p.R847H	TCGA-IG-A4QS	ESCA	TCGA	PPGY	ITCH	838:841	Mutation rewiring degron network	0.1667
p.R847H	DO234239	ESAD	ICGC	PPGY	ITCH	838:841	Mutation rewiring degron network	0.1667
p.R847H	DO234291	ESAD	ICGC	PPGY	ITCH	838:841	Mutation rewiring degron network	0.1667
p.R847H	DO233863	GACA	ICGC	PPGY	ITCH	838:841	Mutation rewiring degron network	0.1667
p.R847H	SIDM02031	Esophageal Carcinoma	GDSC	PPGY	ITCH	838:841	Mutation rewiring degron network	0.1667
p.R847H	SIDM00223	Small Cell Lung Carcinoma	GDSC	PPGY	ITCH	838:841	Mutation rewiring degron network	0.1667
p.R847H	ACH-000429	Kidney Cancer	CCLE	PPGY	ITCH	838:841	Mutation rewiring degron network	0.1667
p.R847H	ACH-002144	Lung Cancer	CCLE	PPGY	ITCH	838:841	Mutation rewiring degron network	0.1667
p.R847H	IST-SL1	lung	COSMIC	PPGY	ITCH	838:841	Mutation rewiring degron network	0.1667
p.S538L	TCGA-IM-A41Y	THCA	TCGA	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation rewiring degron network	0.0556
p.S538L	DO48167	THCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation rewiring degron network	0.0556
p.P842S	TCGA-KD-A5QT	SARC	TCGA	PPGY	ITCH	838:841	Mutation rewiring degron network	0.3056
p.P842S	DO223271	SARC	ICGC	PPGY	ITCH	838:841	Mutation rewiring degron network	0.3056
p.P922S	TCGA-QB-AA9O	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1667
p.P922S	TCGA-QB-AA9O	SKCM	TCGA	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1667
p.P922S	DO51267	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1667
p.P922S	DO51267	SKCM	ICGC	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1667
p.P848H	TCGA-UL-AAZ6	BRCA	TCGA	PPGY	ITCH	838:841	Mutation substituting flanking lysine	0.25
p.P848H	DO219644	BRCA	ICGC	PPGY	ITCH	838:841	Mutation substituting flanking lysine	0.25
p.Q952P	DO48414	BLCA	ICGC	AASTT	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1389
p.Q952P	DO229010	COCA	ICGC	AASTT	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1389
p.Q952P	DO229013	COCA	ICGC	AASTT	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1389
p.Q952P	DO229016	COCA	ICGC	AASTT	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1389
p.Q952P	DO229003	COCA	ICGC	AASTT	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1389
p.Q952P	DO229005	COCA	ICGC	AASTT	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1389
p.P849A	DO229003	COCA	ICGC	PPGY	ITCH	838:841	Mutation rewiring degron network	0.1111
p.L935H	DO234281	ESAD	ICGC	PKSTS	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.25
p.Y851C	DO223106	ESCA	ICGC	PPGY	ITCH	838:841	Mutation rewiring degron network	0.0556
p.L828F	DO233150	GACA	ICGC	PPGY	ITCH	838:841	Mutation substituting flanking lysine	0.1667
p.G917S	DO233272	GACA	ICGC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.3056
p.N553S	DO233205	GACA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation altering degron motif	0.7069
p.T972P	DO233817	GACA	ICGC	AASTT	DEG_SPOP_SBC_1	959:963	Mutation substituting flanking lysine	0.1944
p.P842L	DO23226	LINC	ICGC	PPGY	ITCH	838:841	Mutation rewiring degron network	0.3056
p.P842L	DO34464	PACA	ICGC	PPGY	ITCH	838:841	Mutation rewiring degron network	0.3056
p.K959R	DO23448	LINC	ICGC	AASTT	DEG_SPOP_SBC_1	959:963	Mutation altering degron motif	0.7237
p.T957M	DO228253	MALY	ICGC	AASTT	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.2778
p.K904Q	DO222908	MELA	ICGC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation substituting flanking lysine	0.2222
p.A837T	SIDM00433	T-Lymphoblastic Leukemia	GDSC	PPGY	ITCH	838:841	Mutation rewiring degron network	0.3056
p.A837T	ACH-000795	Leukemia	CCLE	PPGY	ITCH	838:841	Mutation rewiring degron network	0.3056
p.A837T	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	838:841	Mutation rewiring degron network	0.3056
p.P848S	SIDM01175	Other Sarcomas	GDSC	PPGY	ITCH	838:841	Mutation substituting flanking lysine	0.25
p.P848S	ACH-002309	Sarcoma	CCLE	PPGY	ITCH	838:841	Mutation substituting flanking lysine	0.25
p.P848S	SW684	soft tissue	COSMIC	PPGY	ITCH	838:841	Mutation substituting flanking lysine	0.25
p.N958K	SIDM00789	Colorectal Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.3056
p.N958K	ACH-000997	Colon/Colorectal Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.3056
p.N958K	ACH-001061	Colon/Colorectal Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.3056
p.N958K	HCT-15	large intestine	COSMIC	AASTT	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.3056
p.G845A	SIDM00042	Pancreatic Carcinoma	GDSC	PPGY	ITCH	838:841	Mutation rewiring degron network	0.2222
p.G845A	ACH-002186	Pancreatic Cancer	CCLE	PPGY	ITCH	838:841	Mutation rewiring degron network	0.2222
p.G845A	PL4	pancreas	COSMIC	PPGY	ITCH	838:841	Mutation rewiring degron network	0.2222
p.P545L	SIDM00660	Colorectal Carcinoma	GDSC	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation rewiring degron network	0.25
p.P545L	ACH-000985	Colon/Colorectal Cancer	CCLE	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation rewiring degron network	0.25
p.P545L	LS-411N	large intestine	COSMIC	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation rewiring degron network	0.25
p.M554L	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation altering degron motif	0.711
p.M554L	ACH-000824	Esophageal Cancer	CCLE	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation altering degron motif	0.711
p.M554L	KYSE-510	oesophagus	COSMIC	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation altering degron motif	0.711
p.K914N	SIDM00282	Colorectal Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation altering degron motif	0.6918
p.K914N	ACH-000998	Colon/Colorectal Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	912:916	Mutation altering degron motif	0.6918
p.K914N	CW-2	large intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation altering degron motif	0.6918
p.L903M	SIDM01102	Non-Cancerous	GDSC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.0833
p.L903M	ACH-002316	Non-Cancerous	CCLE	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.0833
p.L903M	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.0833
p.V962F	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	959:963	Mutation altering degron motif	0.7068
p.V962F	ACH-000596	Lung Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	959:963	Mutation altering degron motif	0.7068
p.V962F	LCLC-97TM1	lung	COSMIC	AASTT	DEG_SPOP_SBC_1	959:963	Mutation altering degron motif	0.7068
p.L546I	SIDM00721	Small Cell Lung Carcinoma	GDSC	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation rewiring degron network	0.2778
p.L546I	ACH-002171	Lung Cancer	CCLE	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation rewiring degron network	0.2778
p.L546I	NCI-H250	lung	COSMIC	PTTPSSS	DEG_SCF_FBW7_1	548:554	Mutation rewiring degron network	0.2778
p.T973A	SIDM01768	Melanoma	GDSC	AASTT	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0556
p.T973A	ACH-000899	Skin Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.0556
p.A951V	SIDM01588	Endometrial Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1111
p.A951V	ACH-000993	Endometrial/Uterine Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	959:963	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MTUS2

UniProt ID: Q5JR59

Entrez ID: 23281

Protein name: Microtubule-associated tumor suppressor candidate 2 (Cardiac zipper protein) (Microtubule plus-end tracking protein TIP150) (Tracking protein of 150 kDa)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MTUS2 in