DegronMD

Uniprot ID: Q5JR59

Source protein: Microtubule-associated tumor suppressor candidate 2

Source gene: MTUS2

Class: DEG_SCF_FBW7_1

Location: 548:554

E3 ligase: FBXW7

DEGRON score: 0.6739

ASA_SCORE: 83.0857

COIL: 0.8961

CONS_SCORE: 0.4022

DSS_SCORE: 0.4745

HELIX: 0.0857

FCONS_SCORE: 1.0201

RIG_SCORE: 0.6752

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V539F	TCGA-13-0920	OV	TCGA	PTTPSSS	DEG_SCF_FBW7_1	0.0833
p.V539F	DO28099	OV	ICGC	PTTPSSS	DEG_SCF_FBW7_1	0.0833
p.L540I	TCGA-A5-A2K5	UCEC	TCGA	PTTPSSS	DEG_SCF_FBW7_1	0.1111
p.L540I	TCGA-QF-A5YS	UCEC	TCGA	PTTPSSS	DEG_SCF_FBW7_1	0.1111
p.L540I	DO52426	UCEC	ICGC	PTTPSSS	DEG_SCF_FBW7_1	0.1111
p.L540I	DO41379	UCEC	ICGC	PTTPSSS	DEG_SCF_FBW7_1	0.1111
p.P561S	TCGA-AJ-A3EK	UCEC	TCGA	PTTPSSS	DEG_SCF_FBW7_1	0.1389
p.P561S	DO41584	UCEC	ICGC	PTTPSSS	DEG_SCF_FBW7_1	0.1389
p.T551N	TCGA-BS-A0UV	UCEC	TCGA	PTTPSSS	DEG_SCF_FBW7_1	0.7055
p.T551N	DO42793	UCEC	ICGC	PTTPSSS	DEG_SCF_FBW7_1	0.7055
p.P561L	TCGA-D3-A2JD	SKCM	TCGA	PTTPSSS	DEG_SCF_FBW7_1	0.1389
p.P561L	DO37543	SKCM	ICGC	PTTPSSS	DEG_SCF_FBW7_1	0.1389
p.S563G	TCGA-DF-A2KN	UCEC	TCGA	PTTPSSS	DEG_SCF_FBW7_1	0.0833
p.S563G	DO223282	UCEC	ICGC	PTTPSSS	DEG_SCF_FBW7_1	0.0833
p.T555A	TCGA-G4-6588	COAD	TCGA	PTTPSSS	DEG_SCF_FBW7_1	0.3056
p.T555A	DO10140	COAD	ICGC	PTTPSSS	DEG_SCF_FBW7_1	0.3056
p.S538L	TCGA-IM-A41Y	THCA	TCGA	PTTPSSS	DEG_SCF_FBW7_1	0.0556
p.S538L	DO48167	THCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	0.0556
p.N553S	DO233205	GACA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	0.7069
p.P545L	SIDM00660	Colorectal Carcinoma	GDSC	PTTPSSS	DEG_SCF_FBW7_1	0.25
p.P545L	ACH-000985	Colon/Colorectal Cancer	CCLE	PTTPSSS	DEG_SCF_FBW7_1	0.25
p.P545L	LS-411N	large_intestine	COSMIC	PTTPSSS	DEG_SCF_FBW7_1	0.25
p.M554L	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PTTPSSS	DEG_SCF_FBW7_1	0.711
p.M554L	ACH-000824	Esophageal Cancer	CCLE	PTTPSSS	DEG_SCF_FBW7_1	0.711
p.M554L	KYSE-510	oesophagus	COSMIC	PTTPSSS	DEG_SCF_FBW7_1	0.711
p.L546I	SIDM00721	Small Cell Lung Carcinoma	GDSC	PTTPSSS	DEG_SCF_FBW7_1	0.2778
p.L546I	ACH-002171	Lung Cancer	CCLE	PTTPSSS	DEG_SCF_FBW7_1	0.2778
p.L546I	NCI-H250	lung	COSMIC	PTTPSSS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JR59	Microtubule-associated tumor suppressor candidate 2	DEG_SCF_FBW7_1	548:554	PTTPSSS	FBXW7	0.6739	More...
Q5SNT2	Transmembrane protein 201	DEG_SCF_FBW7_1	551:557	PTTPSSS	FBXW7	0.9402	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTPSSS

Degron related mutations and impact score

Drug responses associated with MTUS2 mutations

All proteins holding degron of PTTPSSS