DegronMD - Q5SNT2(TMEM201)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D610N	TCGA-AP-A0LM	UCEC	TCGA	VDTTT	DEG_SPOP_SBC_1	619:623	Mutation rewiring degron network	0.0833
p.D610N	DO43306	UCEC	ICGC	VDTTT	DEG_SPOP_SBC_1	619:623	Mutation rewiring degron network	0.0833
p.E549D	TCGA-AP-A1DK	UCEC	TCGA	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation rewiring degron network	0.2778
p.R522C	TCGA-B5-A11E	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2222
p.R522C	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	VASSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2222
p.R522C	ACH-002272	Lymphoma	CCLE	VASSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2222
p.R522C	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2222
p.G565S	TCGA-B5-A11W	UCEC	TCGA	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation rewiring degron network	0.1111
p.G565S	DO42264	UCEC	ICGC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation rewiring degron network	0.1111
p.A507S	TCGA-B5-A3FC	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1389
p.A515T	TCGA-EO-A22U	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	514:518	Mutation altering degron motif	0.6028
p.R524H	TCGA-L5-A4OI	ESCA	TCGA	VASSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1667
p.A623V	DO8151	COAD	ICGC	VDTTT	DEG_SPOP_SBC_1	619:623	Mutation altering degron motif	0.6936
p.A623V	DO8192	COAD	ICGC	VDTTT	DEG_SPOP_SBC_1	619:623	Mutation altering degron motif	0.6936
p.S561L	DO222765	COCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation rewiring degron network	0.2222
p.P555L	DO222840	COCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation altering degron motif	0.7582
p.P555L	DO229010	COCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation altering degron motif	0.7582
p.P555L	DO229013	COCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation altering degron motif	0.7582
p.P555L	DO229016	COCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation altering degron motif	0.7582
p.P555L	DO229003	COCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation altering degron motif	0.7582
p.P555L	DO229005	COCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation altering degron motif	0.7582
p.G611V	DO219919	DLBC	ICGC	VDTTT	DEG_SPOP_SBC_1	619:623	Mutation blocking phosphorylation signal	0.5556
p.S468F	DO222306	DLBC	ICGC	DSGYLFS	DEG_SCF_TRCP1_1	465:471	Mutation altering degron motif	0.7982
p.S468F	DO229054	LICA	ICGC	DSGYLFS	DEG_SCF_TRCP1_1	465:471	Mutation altering degron motif	0.7982
p.A563T	DO233089	GACA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation rewiring degron network	0.1667
p.R463Q	DO233634	GACA	ICGC	DSGYLFS	DEG_SCF_TRCP1_1	465:471	Mutation rewiring degron network	0.2778
p.R474L	DO228952	LICA	ICGC	DSGYLFS	DEG_SCF_TRCP1_1	465:471	Mutation rewiring degron network	0.25
p.G467S	DO220844	MELA	ICGC	DSGYLFS	DEG_SCF_TRCP1_1	465:471	Mutation altering degron motif	0.6993
p.G467S	SIDM02026	Colorectal Carcinoma	GDSC	DSGYLFS	DEG_SCF_TRCP1_1	465:471	Mutation altering degron motif	0.6993
p.S509F	DO222875	MELA	ICGC	VASSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1944
p.PP546PS	DO222843	MELA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation rewiring degron network	0
p.L567I	DO233298	NACA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation rewiring degron network	0.0556
p.R553G	DO229268	THCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation altering degron motif	0.7568
p.E525D	DO42033	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1389
p.P547H	SIDM00633	Breast Carcinoma	GDSC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation rewiring degron network	0.2222
p.P547H	SIDM01112	Osteosarcoma	GDSC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation rewiring degron network	0.2222
p.P547H	SIDM00529	Breast Carcinoma	GDSC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation rewiring degron network	0.2222
p.P547H	SIDM00879	Breast Carcinoma	GDSC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation rewiring degron network	0.2222
p.P547H	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation rewiring degron network	0.2222
p.P544L	SIDM00217	Colorectal Carcinoma	GDSC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation rewiring degron network	0.1389
p.S557F	SIDM01059	Melanoma	GDSC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation altering degron motif	0.7982
p.S557F	ACH-000915	Skin Cancer	CCLE	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation altering degron motif	0.7982
p.S517I	ACH-000761	Gastric Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	514:518	Mutation altering degron motif	0.7341
p.A511S	ACH-000936	Ovarian Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.25
p.A511S	EFO-27	ovary	COSMIC	VASSS	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.25
p.R474H	ACH-000967	Colon/Colorectal Cancer	CCLE	DSGYLFS	DEG_SCF_TRCP1_1	465:471	Mutation rewiring degron network	0.25
p.E559K	ACH-000994	Endometrial/Uterine Cancer	CCLE	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation rewiring degron network	0.2778
p.P551R	ACH-001668	Teratoma	CCLE	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation altering degron motif	0.7512

Kaplan plot for TMEM201 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM201

UniProt ID: Q5SNT2

Entrez ID: 199953

Protein name: Transmembrane protein 201 (Spindle-associated membrane protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM201 in