DegronMD - Q5SNT2(TMEM201)

FUNCTION: Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin-dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (... View more >>

GO - Biological processes (BP): centrosome localization [GO:0051642]; fibroblast migration [GO:0010761]; nuclear envelope organization [GO:0006998]; nuclear migration along microtubule [GO:0030473]; protein localization to nuclear envelope [GO:0090435]

GO - Molecular function (MF): actin filament binding [GO:0051015]; lamin binding [GO:0005521]

GO - Cellular component (CC): cytoplasm [GO:0005737]; integral component of nuclear inner membrane [GO:0005639]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; spindle pole [GO:0000922]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
PTTPSSS	DEG_SCF_FBW7_1	FBXW7	Transmembrane protein 201	551:557	More..
DSGYLFS	DEG_SCF_TRCP1_1	BTRC	Transmembrane protein 201	465:471	More..
VASSS	DEG_SPOP_SBC_1	SPOP	Transmembrane protein 201	514:518	More..
VDTTT	DEG_SPOP_SBC_1	SPOP	Transmembrane protein 201	619:623	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S468F	DO222306	DLBC	ICGC	DSGYLFS	DEG_SCF_TRCP1_1	465:471	Mutation altering degron motif	0.7982
p.S468F	DO229054	LICA	ICGC	DSGYLFS	DEG_SCF_TRCP1_1	465:471	Mutation altering degron motif	0.7982
p.S557F	SIDM01059	Melanoma	GDSC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation altering degron motif	0.7982
p.S557F	ACH-000915	Skin Cancer	CCLE	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation altering degron motif	0.7982
p.P555L	DO222840	COCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation altering degron motif	0.7582
p.P555L	DO229010	COCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation altering degron motif	0.7582
p.P555L	DO229013	COCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation altering degron motif	0.7582
p.P555L	DO229016	COCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation altering degron motif	0.7582
p.P555L	DO229003	COCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation altering degron motif	0.7582
p.P555L	DO229005	COCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation altering degron motif	0.7582
p.R553G	DO229268	THCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation altering degron motif	0.7568
p.P551R	ACH-001668	Teratoma	CCLE	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation altering degron motif	0.7512
p.S517I	ACH-000761	Gastric Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	514:518	Mutation altering degron motif	0.7341
p.G467S	DO220844	MELA	ICGC	DSGYLFS	DEG_SCF_TRCP1_1	465:471	Mutation altering degron motif	0.6993
p.G467S	SIDM02026	Colorectal Carcinoma	GDSC	DSGYLFS	DEG_SCF_TRCP1_1	465:471	Mutation altering degron motif	0.6993
p.A623V	DO8151	COAD	ICGC	VDTTT	DEG_SPOP_SBC_1	619:623	Mutation altering degron motif	0.6936
p.A623V	DO8192	COAD	ICGC	VDTTT	DEG_SPOP_SBC_1	619:623	Mutation altering degron motif	0.6936
p.A515T	TCGA-EO-A22U	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	514:518	Mutation altering degron motif	0.6028
p.G611V	DO219919	DLBC	ICGC	VDTTT	DEG_SPOP_SBC_1	619:623	Mutation blocking phosphorylation signal	0.5556
p.E549D	TCGA-AP-A1DK	UCEC	TCGA	PTTPSSS	DEG_SCF_FBW7_1	551:557	Mutation rewiring degron network	0.2778

Showing 1 to 20 of 48 entries

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Kaplan plot for TMEM201 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM201

UniProt ID: Q5SNT2

Entrez ID: 199953

Protein name: Transmembrane protein 201 (Spindle-associated membrane protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM201 in