DegronMD

Uniprot ID: Q5SNT2

Source protein: Transmembrane protein 201

Source gene: TMEM201

Class: DEG_SCF_TRCP1_1

Location: 465:471

E3 ligase: BTRC

DEGRON score: 0.999

ASA_SCORE: 70.5429

COIL: 0.8153

CONS_SCORE: 0.438

DSS_SCORE: 0.453

HELIX: 0.1006

FCONS_SCORE: 1.1151

RIG_SCORE: 0.7066

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S468F	DO222306	DLBC	ICGC	DSGYLFS	DEG_SCF_TRCP1_1	0.7982
p.S468F	DO229054	LICA	ICGC	DSGYLFS	DEG_SCF_TRCP1_1	0.7982
p.R463Q	DO233634	GACA	ICGC	DSGYLFS	DEG_SCF_TRCP1_1	0.2778
p.R474L	DO228952	LICA	ICGC	DSGYLFS	DEG_SCF_TRCP1_1	0.25
p.G467S	DO220844	MELA	ICGC	DSGYLFS	DEG_SCF_TRCP1_1	0.6993
p.G467S	SIDM02026	Colorectal Carcinoma	GDSC	DSGYLFS	DEG_SCF_TRCP1_1	0.6993
p.R474H	ACH-000967	Colon/Colorectal Cancer	CCLE	DSGYLFS	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SNT2	Transmembrane protein 201	DEG_SCF_TRCP1_1	465:471	DSGYLFS	BTRC	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons