DegronMD

Uniprot ID: Q5SNT2

Source protein: Transmembrane protein 201

Source gene: TMEM201

Class: DEG_SPOP_SBC_1

Location: 619:623

E3 ligase: SPOP

DEGRON score: 0.9756

ASA_SCORE: 73.8

COIL: 0.6232

CONS_SCORE: 0.4632

DSS_SCORE: 0.4026

HELIX: 0.04

FCONS_SCORE: 1.203

RIG_SCORE: 0.786

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D610N	TCGA-AP-A0LM	UCEC	TCGA	VDTTT	DEG_SPOP_SBC_1	0.0833
p.D610N	DO43306	UCEC	ICGC	VDTTT	DEG_SPOP_SBC_1	0.0833
p.A623V	DO8151	COAD	ICGC	VDTTT	DEG_SPOP_SBC_1	0.6936
p.A623V	DO8192	COAD	ICGC	VDTTT	DEG_SPOP_SBC_1	0.6936
p.G611V	DO219919	DLBC	ICGC	VDTTT	DEG_SPOP_SBC_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SNT2	Transmembrane protein 201	DEG_SPOP_SBC_1	619:623	VDTTT	SPOP	0.9756	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	1416:1420	VDTTT	SPOP	0.9343	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons