DegronMD

Uniprot ID: Q8IZF6

Source protein: Adhesion G-protein coupled receptor G4

Source gene: ADGRG4

Class: DEG_SPOP_SBC_1

Location: 1416:1420

E3 ligase: SPOP

DEGRON score: 0.9343

ASA_SCORE: 89.42

COIL: 0.865

CONS_SCORE: 0.7411

DSS_SCORE: 0.4329

HELIX: 0.0154

FCONS_SCORE: 0.9745

RIG_SCORE: 0.7725

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1429T	SIDM00549	B-Lymphoblastic Leukemia	GDSC	VDTTT	DEG_SPOP_SBC_1	0.0833
p.P1429T	LC4-1	haematopoietic_and_lymphoid_tissue	COSMIC	VDTTT	DEG_SPOP_SBC_1	0.0833
p.G1412R	NCI-H1155	lung	COSMIC	VDTTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SNT2	Transmembrane protein 201	DEG_SPOP_SBC_1	619:623	VDTTT	SPOP	0.9756	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	1416:1420	VDTTT	SPOP	0.9343	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons