DegronMD

Uniprot ID: Q5SNT2

Source protein: Transmembrane protein 201

Source gene: TMEM201

Class: DEG_SCF_FBW7_1

Location: 551:557

E3 ligase: FBXW7

DEGRON score: 0.9402

ASA_SCORE: 68.5714

COIL: 0.9093

CONS_SCORE: 0.3788

DSS_SCORE: 0.8383

HELIX: 0.064

FCONS_SCORE: 0.962

RIG_SCORE: 0.4887

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E549D	TCGA-AP-A1DK	UCEC	TCGA	PTTPSSS	DEG_SCF_FBW7_1	0.2778
p.G565S	TCGA-B5-A11W	UCEC	TCGA	PTTPSSS	DEG_SCF_FBW7_1	0.1111
p.G565S	DO42264	UCEC	ICGC	PTTPSSS	DEG_SCF_FBW7_1	0.1111
p.S561L	DO222765	COCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	0.2222
p.P555L	DO222840	COCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	0.7582
p.P555L	DO229010	COCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	0.7582
p.P555L	DO229013	COCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	0.7582
p.P555L	DO229016	COCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	0.7582
p.P555L	DO229003	COCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	0.7582
p.P555L	DO229005	COCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	0.7582
p.A563T	DO233089	GACA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	0.1667
p.PP546PS	DO222843	MELA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	0
p.L567I	DO233298	NACA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	0.0556
p.R553G	DO229268	THCA	ICGC	PTTPSSS	DEG_SCF_FBW7_1	0.7568
p.P547H	SIDM00633	Breast Carcinoma	GDSC	PTTPSSS	DEG_SCF_FBW7_1	0.2222
p.P547H	SIDM01112	Osteosarcoma	GDSC	PTTPSSS	DEG_SCF_FBW7_1	0.2222
p.P547H	SIDM00529	Breast Carcinoma	GDSC	PTTPSSS	DEG_SCF_FBW7_1	0.2222
p.P547H	SIDM00879	Breast Carcinoma	GDSC	PTTPSSS	DEG_SCF_FBW7_1	0.2222
p.P547H	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PTTPSSS	DEG_SCF_FBW7_1	0.2222
p.P544L	SIDM00217	Colorectal Carcinoma	GDSC	PTTPSSS	DEG_SCF_FBW7_1	0.1389
p.S557F	SIDM01059	Melanoma	GDSC	PTTPSSS	DEG_SCF_FBW7_1	0.7982
p.S557F	ACH-000915	Skin Cancer	CCLE	PTTPSSS	DEG_SCF_FBW7_1	0.7982
p.E559K	ACH-000994	Endometrial/Uterine Cancer	CCLE	PTTPSSS	DEG_SCF_FBW7_1	0.2778
p.P551R	ACH-001668	Teratoma	CCLE	PTTPSSS	DEG_SCF_FBW7_1	0.7512

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JR59	Microtubule-associated tumor suppressor candidate 2	DEG_SCF_FBW7_1	548:554	PTTPSSS	FBXW7	0.6739	More...
Q5SNT2	Transmembrane protein 201	DEG_SCF_FBW7_1	551:557	PTTPSSS	FBXW7	0.9402	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons