DegronMD

Uniprot ID: Q5JR59

Source protein: Microtubule-associated tumor suppressor candidate 2

Source gene: MTUS2

Class: DEG_SPOP_SBC_1

Location: 928:932

E3 ligase: SPOP

DEGRON score: 0.974

ASA_SCORE: 104.3

COIL: 0.9432

CONS_SCORE: 0.4861

DSS_SCORE: 0.7596

HELIX: 0.0258

FCONS_SCORE: 0.9709

RIG_SCORE: 0.5662

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R918Q	TCGA-AZ-4615	COAD	TCGA	PKSTS	DEG_SPOP_SBC_1	0.0556
p.R918Q	TCGA-EO-A22S	UCEC	TCGA	PKSTS	DEG_SPOP_SBC_1	0.0556
p.R918Q	DO7977	COAD	ICGC	PKSTS	DEG_SPOP_SBC_1	0.0556
p.R918Q	DO233810	GACA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.0556
p.R918Q	DO41590	UCEC	ICGC	PKSTS	DEG_SPOP_SBC_1	0.0556
p.R918L	TCGA-BF-A1Q0	SKCM	TCGA	PKSTS	DEG_SPOP_SBC_1	0.0556
p.R918L	DO47374	SKCM	ICGC	PKSTS	DEG_SPOP_SBC_1	0.0556
p.R931H	TCGA-BR-8679	STAD	TCGA	PKSTS	DEG_SPOP_SBC_1	0.8244
p.R931H	TCGA-S9-A7R1	LGG	TCGA	PKSTS	DEG_SPOP_SBC_1	0.8244
p.R931H	DO234250	ESAD	ICGC	PKSTS	DEG_SPOP_SBC_1	0.8244
p.R931H	DO51839	LGG	ICGC	PKSTS	DEG_SPOP_SBC_1	0.8244
p.R931H	DO47875	STAD	ICGC	PKSTS	DEG_SPOP_SBC_1	0.8244
p.S940F	TCGA-DF-A2KU	UCEC	TCGA	PKSTS	DEG_SPOP_SBC_1	0.1111
p.S940F	DO220875	MELA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.1111
p.S940F	DO223286	UCEC	ICGC	PKSTS	DEG_SPOP_SBC_1	0.1111
p.L935I	TCGA-DK-A6AW	BLCA	TCGA	PKSTS	DEG_SPOP_SBC_1	0.25
p.L935I	DO48566	BLCA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.25
p.A937V	TCGA-FP-A4BE	STAD	TCGA	PKSTS	DEG_SPOP_SBC_1	0.6389
p.A937V	TCGA-W2-A7UY	PCPG	TCGA	PKSTS	DEG_SPOP_SBC_1	0.6389
p.A937V	DO891	BOCA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.6389
p.A937V	DO229364	BTCA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.6389
p.A937V	DO48016	STAD	ICGC	PKSTS	DEG_SPOP_SBC_1	0.6389
p.P922S	TCGA-QB-AA9O	SKCM	TCGA	PKSTS	DEG_SPOP_SBC_1	0.1667
p.P922S	DO51267	SKCM	ICGC	PKSTS	DEG_SPOP_SBC_1	0.1667
p.L935H	DO234281	ESAD	ICGC	PKSTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14939	Phospholipase D2	DEG_SPOP_SBC_1	583:587	PKSTS	SPOP	0.7698	More...
O43497	Voltage-dependent T-type calcium channel subunit alpha-1G	DEG_SPOP_SBC_1	1051:1055	PKSTS	SPOP	0.9183	More...
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	278:282	PKSTS	SPOP	0.8251	More...
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	861:865	PKSTS	SPOP	0.994	More...
Q08495	Dematin	DEG_SPOP_SBC_1	88:92	PKSTS	SPOP	0.8879	More...
Q14154	DAP3-binding cell death enhancer 1	DEG_SPOP_SBC_1	25:29	PKSTS	SPOP	0.9768	More...
Q5JR59	Microtubule-associated tumor suppressor candidate 2	DEG_SPOP_SBC_1	928:932	PKSTS	SPOP	0.974	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	2971:2975	PKSTS	SPOP	0.5397	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	234:238	PKSTS	SPOP	0.6925	More...
Q9H808	Transducin-like enhancer protein 6	DEG_SPOP_SBC_1	13:17	PKSTS	SPOP	0.6634	More...
Q9NW75	G patch domain-containing protein 2	DEG_SPOP_SBC_1	513:517	PKSTS	SPOP	0.8361	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons