DegronMD - Q9H808(TLE6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P12H	TCGA-AH-6549	READ	TCGA	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.3056
p.P12H	DO37066	READ	ICGC	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.3056
p.S3F	TCGA-AN-A046	BRCA	TCGA	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.0556
p.S3F	DO1285	BRCA	ICGC	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.0556
p.S17L	TCGA-CA-6717	COAD	TCGA	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.7667
p.S17L	DO8264	COAD	ICGC	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.7667
p.W8C	DO228126	EOPC	ICGC	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1944
p.D7E	DO228126	EOPC	ICGC	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1667
p.K27R	DO15719	HNSC	ICGC	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.0556
p.Q18H	DO228971	LICA	ICGC	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.3056
p.P12L	DO220891	MELA	ICGC	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.3056
p.G21R	DO46394	OV	ICGC	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.2222
p.L9F	DO37551	SKCM	ICGC	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.2222
p.N24K	DO229229	THCA	ICGC	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1389
p.G11C	SIDM00789	Colorectal Carcinoma	GDSC	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.2778
p.G11C	ACH-000997	Colon/Colorectal Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.2778
p.G11C	ACH-001061	Colon/Colorectal Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.2778
p.G11C	HCT-15	large intestine	COSMIC	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.2778
p.Q6H	SIDM00309	Mesothelioma	GDSC	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1389
p.Q6H	SIDM00760	Small Cell Lung Carcinoma	GDSC	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1389
p.S25C	ACH-000854	Myeloma	CCLE	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1111
p.L13S	CTB-1	haematopoietic and lymphoid tissue	COSMIC	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.7667
p.G14R	DOK	upper aerodigestive tract	COSMIC	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.7568
p.R11W	OCI-AML3	haematopoietic and lymphoid tissue	COSMIC	PKSTS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.2778

Kaplan plot for TLE6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TLE6

UniProt ID: Q9H808

Entrez ID: 79816

Protein name: Transducin-like enhancer protein 6

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TLE6 in