DegronMD - Q9NW75(GPATCH2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V321F	TCGA-05-4382	LUAD	TCGA	TELDKNVPDP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.3056
p.V321F	DO24900	LUAD	ICGC	TELDKNVPDP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.3056
p.E323Q	TCGA-37-3783	LUSC	TCGA	TELDKNVPDP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.25
p.E323Q	DO26734	LUSC	ICGC	TELDKNVPDP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.25
p.G505A	TCGA-85-8071	LUSC	TCGA	PKSTS	DEG_SPOP_SBC_1	513:517	Mutation rewiring degron network	0.1111
p.G505A	DO26755	LUSC	ICGC	PKSTS	DEG_SPOP_SBC_1	513:517	Mutation rewiring degron network	0.1111
p.P310S	TCGA-90-A4ED	LUSC	TCGA	TELDKNVPDP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.3056
p.P310S	DO45482	LUSC	ICGC	TELDKNVPDP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.3056
p.D314H	TCGA-AJ-A3TW	UCEC	TCGA	TELDKNVPDP	DEG_COP1_1	311:320	Mutation altering degron motif	0.7688
p.D314H	DO43723	UCEC	ICGC	TELDKNVPDP	DEG_COP1_1	311:320	Mutation altering degron motif	0.7688
p.S100N	TCGA-AP-A0LM	UCEC	TCGA	DYR	CBL_MET	102:104	Mutation rewiring degron network	0.2778
p.S100N	DO43306	UCEC	ICGC	DYR	CBL_MET	102:104	Mutation rewiring degron network	0.2778
p.K307N	TCGA-EE-A3AD	SKCM	TCGA	TELDKNVPDP	DEG_COP1_1	311:320	Mutation blocking ubiquitination signal	0.6667
p.K307N	DO37707	SKCM	ICGC	TELDKNVPDP	DEG_COP1_1	311:320	Mutation blocking ubiquitination signal	0.6667
p.E323D	TCGA-EI-6883	READ	TCGA	TELDKNVPDP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.25
p.E323D	DO36443	READ	ICGC	TELDKNVPDP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.25
p.D309E	TCGA-EI-6885	READ	TCGA	TELDKNVPDP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.2778
p.D309E	DO37283	READ	ICGC	TELDKNVPDP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.2778
p.I325S	TCGA-EO-A22R	UCEC	TCGA	TELDKNVPDP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.1944
p.I325S	DO42713	UCEC	ICGC	TELDKNVPDP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.1944
p.P522L	TCGA-F4-6807	COAD	TCGA	PKSTS	DEG_SPOP_SBC_1	513:517	Mutation rewiring degron network	0.1944
p.P522L	DO9716	COAD	ICGC	PKSTS	DEG_SPOP_SBC_1	513:517	Mutation rewiring degron network	0.1944
p.P303S	TCGA-FI-A2F4	UCEC	TCGA	TELDKNVPDP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.1111
p.P303S	DO43434	UCEC	ICGC	TELDKNVPDP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.1111
p.P320H	TCGA-WQ-A9G7	LIHC	TCGA	TELDKNVPDP	DEG_COP1_1	311:320	Mutation altering degron motif	0.7694
p.P320H	DO52326	LIHC	ICGC	TELDKNVPDP	DEG_COP1_1	311:320	Mutation altering degron motif	0.7694
p.K514I	DO48386	BLCA	ICGC	PKSTS	DEG_SPOP_SBC_1	513:517	Mutation altering degron motif	0.642
p.E312K	DO48262	ESCA	ICGC	TELDKNVPDP	DEG_COP1_1	311:320	Mutation altering degron motif	0.591
p.F510Y	DO231958	LICA	ICGC	PKSTS	DEG_SPOP_SBC_1	513:517	Mutation rewiring degron network	0.25
p.T516N	DO229028	LICA	ICGC	PKSTS	DEG_SPOP_SBC_1	513:517	Mutation altering degron motif	0.8166
p.P513T	DO229006	LICA	ICGC	PKSTS	DEG_SPOP_SBC_1	513:517	Mutation altering degron motif	0.7031
p.W305L	SIDM02021	Esophageal Carcinoma	GDSC	TELDKNVPDP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.1667
p.A518S	SIDM00435	Acute Myeloid Leukemia	GDSC	PKSTS	DEG_SPOP_SBC_1	513:517	Mutation rewiring degron network	0.3056
p.A518S	ACH-000369	Leukemia	CCLE	PKSTS	DEG_SPOP_SBC_1	513:517	Mutation rewiring degron network	0.3056
p.A518S	MOLM-16	haematopoietic and lymphoid tissue	COSMIC	PKSTS	DEG_SPOP_SBC_1	513:517	Mutation rewiring degron network	0.3056
p.S527T	SIDM01090	Colorectal Carcinoma	GDSC	PKSTS	DEG_SPOP_SBC_1	513:517	Mutation rewiring degron network	0.0556
p.S527T	ACH-000943	Colon/Colorectal Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	513:517	Mutation rewiring degron network	0.0556
p.S527T	RKO	large intestine	COSMIC	PKSTS	DEG_SPOP_SBC_1	513:517	Mutation rewiring degron network	0.0556
p.D102E	SIDM00791	Chronic Myelogenous Leukemia	GDSC	DYR	CBL_MET	102:104	Mutation altering degron motif	0.6758
p.D102E	K-562	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	102:104	Mutation altering degron motif	0.6758
p.D309Y	SIDM01128	Small Cell Lung Carcinoma	GDSC	TELDKNVPDP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.2778
p.D309Y	ACH-000767	Lung Cancer	CCLE	TELDKNVPDP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.2778
p.D309Y	NCI-H526	lung	COSMIC	TELDKNVPDP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.2778
p.N106Y	SIDM01749	Osteosarcoma	GDSC	DYR	CBL_MET	102:104	Mutation rewiring degron network	0.2778
p.N106Y	ACH-000340	Non-Cancerous	CCLE	DYR	CBL_MET	102:104	Mutation rewiring degron network	0.2778
p.S329Y	ACH-001991	Primary	CCLE	TELDKNVPDP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPATCH2

UniProt ID: Q9NW75

Entrez ID: 55105

Protein name: G patch domain-containing protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GPATCH2 in