DegronMD

Uniprot ID: Q9NW75

Source protein: G patch domain-containing protein 2

Source gene: GPATCH2

Class: DEG_COP1_1

Location: 311:320

E3 ligase: COP1

DEGRON score: 0.845

ASA_SCORE: 86.42

COIL: 0.7681

CONS_SCORE: 0.5094

DSS_SCORE: 0.4781

HELIX: 0.2129

FCONS_SCORE: 0.8815

RIG_SCORE: 0.78

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V321F	TCGA-05-4382	LUAD	TCGA	TELDKNVPDP	DEG_COP1_1	0.3056
p.V321F	DO24900	LUAD	ICGC	TELDKNVPDP	DEG_COP1_1	0.3056
p.E323Q	TCGA-37-3783	LUSC	TCGA	TELDKNVPDP	DEG_COP1_1	0.25
p.E323Q	DO26734	LUSC	ICGC	TELDKNVPDP	DEG_COP1_1	0.25
p.P310S	TCGA-90-A4ED	LUSC	TCGA	TELDKNVPDP	DEG_COP1_1	0.3056
p.P310S	DO45482	LUSC	ICGC	TELDKNVPDP	DEG_COP1_1	0.3056
p.D314H	TCGA-AJ-A3TW	UCEC	TCGA	TELDKNVPDP	DEG_COP1_1	0.7688
p.D314H	DO43723	UCEC	ICGC	TELDKNVPDP	DEG_COP1_1	0.7688
p.K307N	TCGA-EE-A3AD	SKCM	TCGA	TELDKNVPDP	DEG_COP1_1	0.6667
p.K307N	DO37707	SKCM	ICGC	TELDKNVPDP	DEG_COP1_1	0.6667
p.E323D	TCGA-EI-6883	READ	TCGA	TELDKNVPDP	DEG_COP1_1	0.25
p.E323D	DO36443	READ	ICGC	TELDKNVPDP	DEG_COP1_1	0.25
p.D309E	TCGA-EI-6885	READ	TCGA	TELDKNVPDP	DEG_COP1_1	0.2778
p.D309E	DO37283	READ	ICGC	TELDKNVPDP	DEG_COP1_1	0.2778
p.I325S	TCGA-EO-A22R	UCEC	TCGA	TELDKNVPDP	DEG_COP1_1	0.1944
p.I325S	DO42713	UCEC	ICGC	TELDKNVPDP	DEG_COP1_1	0.1944
p.P303S	TCGA-FI-A2F4	UCEC	TCGA	TELDKNVPDP	DEG_COP1_1	0.1111
p.P303S	DO43434	UCEC	ICGC	TELDKNVPDP	DEG_COP1_1	0.1111
p.P320H	TCGA-WQ-A9G7	LIHC	TCGA	TELDKNVPDP	DEG_COP1_1	0.7694
p.P320H	DO52326	LIHC	ICGC	TELDKNVPDP	DEG_COP1_1	0.7694
p.E312K	DO48262	ESCA	ICGC	TELDKNVPDP	DEG_COP1_1	0.591
p.W305L	SIDM02021	Esophageal Carcinoma	GDSC	TELDKNVPDP	DEG_COP1_1	0.1667
p.D309Y	SIDM01128	Small Cell Lung Carcinoma	GDSC	TELDKNVPDP	DEG_COP1_1	0.2778
p.D309Y	ACH-000767	Lung Cancer	CCLE	TELDKNVPDP	DEG_COP1_1	0.2778
p.D309Y	NCI-H526	lung	COSMIC	TELDKNVPDP	DEG_COP1_1	0.2778
p.S329Y	ACH-001991	Primary	CCLE	TELDKNVPDP	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NW75	G patch domain-containing protein 2	DEG_COP1_1	311:320	TELDKNVPDP	COP1	0.845	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons