DegronMD

Uniprot ID: Q9NW75

Source protein: G patch domain-containing protein 2

Source gene: GPATCH2

Class: DEG_SPOP_SBC_1

Location: 513:517

E3 ligase: SPOP

DEGRON score: 0.8361

ASA_SCORE: 94.56

COIL: 0.9036

CONS_SCORE: 0.3758

DSS_SCORE: 0.6216

HELIX: 0.0374

FCONS_SCORE: 0.831

RIG_SCORE: 0.648

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G505A	TCGA-85-8071	LUSC	TCGA	PKSTS	DEG_SPOP_SBC_1	0.1111
p.G505A	DO26755	LUSC	ICGC	PKSTS	DEG_SPOP_SBC_1	0.1111
p.P522L	TCGA-F4-6807	COAD	TCGA	PKSTS	DEG_SPOP_SBC_1	0.1944
p.P522L	DO9716	COAD	ICGC	PKSTS	DEG_SPOP_SBC_1	0.1944
p.K514I	DO48386	BLCA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.642
p.F510Y	DO231958	LICA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.25
p.T516N	DO229028	LICA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.8166
p.P513T	DO229006	LICA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.7031
p.A518S	SIDM00435	Acute Myeloid Leukemia	GDSC	PKSTS	DEG_SPOP_SBC_1	0.3056
p.A518S	ACH-000369	Leukemia	CCLE	PKSTS	DEG_SPOP_SBC_1	0.3056
p.A518S	MOLM-16	haematopoietic_and_lymphoid_tissue	COSMIC	PKSTS	DEG_SPOP_SBC_1	0.3056
p.S527T	SIDM01090	Colorectal Carcinoma	GDSC	PKSTS	DEG_SPOP_SBC_1	0.0556
p.S527T	ACH-000943	Colon/Colorectal Cancer	CCLE	PKSTS	DEG_SPOP_SBC_1	0.0556
p.S527T	RKO	large_intestine	COSMIC	PKSTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14939	Phospholipase D2	DEG_SPOP_SBC_1	583:587	PKSTS	SPOP	0.7698	More...
O43497	Voltage-dependent T-type calcium channel subunit alpha-1G	DEG_SPOP_SBC_1	1051:1055	PKSTS	SPOP	0.9183	More...
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	278:282	PKSTS	SPOP	0.8251	More...
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	861:865	PKSTS	SPOP	0.994	More...
Q08495	Dematin	DEG_SPOP_SBC_1	88:92	PKSTS	SPOP	0.8879	More...
Q14154	DAP3-binding cell death enhancer 1	DEG_SPOP_SBC_1	25:29	PKSTS	SPOP	0.9768	More...
Q5JR59	Microtubule-associated tumor suppressor candidate 2	DEG_SPOP_SBC_1	928:932	PKSTS	SPOP	0.974	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	2971:2975	PKSTS	SPOP	0.5397	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	234:238	PKSTS	SPOP	0.6925	More...
Q9H808	Transducin-like enhancer protein 6	DEG_SPOP_SBC_1	13:17	PKSTS	SPOP	0.6634	More...
Q9NW75	G patch domain-containing protein 2	DEG_SPOP_SBC_1	513:517	PKSTS	SPOP	0.8361	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons