DegronMD

Uniprot ID: P27816

Source protein: Microtubule-associated protein 4

Source gene: MAP4

Class: DEG_SPOP_SBC_1

Location: 861:865

E3 ligase: SPOP

DEGRON score: 0.994

ASA_SCORE: 96.04

COIL: 0.938

CONS_SCORE: 0.5527

DSS_SCORE: 0.6474

HELIX: 0.0264

FCONS_SCORE: 0.974

RIG_SCORE: 0.6173

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R860H	TCGA-IB-7651	PAAD	TCGA	PKSTS	DEG_SPOP_SBC_1	0.3056
p.R860H	DO46657	PAAD	ICGC	PKSTS	DEG_SPOP_SBC_1	0.3056
p.R860H	SIDM00889	Cervical Carcinoma	GDSC	PKSTS	DEG_SPOP_SBC_1	0.3056
p.R860H	C-33-A	cervix	COSMIC	PKSTS	DEG_SPOP_SBC_1	0.3056
p.L853V	DO227709	COCA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.5556
p.L853V	DO229010	COCA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.5556
p.L853V	DO234205	ESAD	ICGC	PKSTS	DEG_SPOP_SBC_1	0.5556
p.L853V	DO228947	LICA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.5556
p.A851E	DO228971	LICA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.0556
p.P855Q	DO229032	LICA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.1667
p.S867G	DO45049	LINC	ICGC	PKSTS	DEG_SPOP_SBC_1	0.2778
p.E851K	DO23533	LIRI	ICGC	PKSTS	DEG_SPOP_SBC_1	0.0556
p.P874T	DO42608	UCEC	ICGC	PKSTS	DEG_SPOP_SBC_1	0.5278
p.L875V	201T	lung	COSMIC	PKSTS	DEG_SPOP_SBC_1	0.0556
p.T872P	OCI-LY-19	haematopoietic_and_lymphoid_tissue	COSMIC	PKSTS	DEG_SPOP_SBC_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14939	Phospholipase D2	DEG_SPOP_SBC_1	583:587	PKSTS	SPOP	0.7698	More...
O43497	Voltage-dependent T-type calcium channel subunit alpha-1G	DEG_SPOP_SBC_1	1051:1055	PKSTS	SPOP	0.9183	More...
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	278:282	PKSTS	SPOP	0.8251	More...
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	861:865	PKSTS	SPOP	0.994	More...
Q08495	Dematin	DEG_SPOP_SBC_1	88:92	PKSTS	SPOP	0.8879	More...
Q14154	DAP3-binding cell death enhancer 1	DEG_SPOP_SBC_1	25:29	PKSTS	SPOP	0.9768	More...
Q5JR59	Microtubule-associated tumor suppressor candidate 2	DEG_SPOP_SBC_1	928:932	PKSTS	SPOP	0.974	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	2971:2975	PKSTS	SPOP	0.5397	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	234:238	PKSTS	SPOP	0.6925	More...
Q9H808	Transducin-like enhancer protein 6	DEG_SPOP_SBC_1	13:17	PKSTS	SPOP	0.6634	More...
Q9NW75	G patch domain-containing protein 2	DEG_SPOP_SBC_1	513:517	PKSTS	SPOP	0.8361	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons