DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PKSTS
Uniprot ID:
Q14154
Source protein:
DAP3-binding cell death enhancer 1
Source gene:
DELE1
Class:
DEG_SPOP_SBC_1
Location:
25:29
E3 ligase:
SPOP
DEGRON score:
0.9768
ASA_SCORE:
77.06
COIL:
0.9446
CONS_SCORE:
0.3941
DSS_SCORE:
0.6609
HELIX:
0.0102
FCONS_SCORE:
1.0197
RIG_SCORE:
0.6254
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with DELE1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PKSTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O14939
Phospholipase D2
DEG_SPOP_SBC_1
583:587
PKSTS
SPOP
0.7698
More...
O43497
Voltage-dependent T-type calcium channel subunit alpha-1G
DEG_SPOP_SBC_1
1051:1055
PKSTS
SPOP
0.9183
More...
O75132
Zinc finger BED domain-containing protein 4
DEG_SPOP_SBC_1
278:282
PKSTS
SPOP
0.8251
More...
P27816
Microtubule-associated protein 4
DEG_SPOP_SBC_1
861:865
PKSTS
SPOP
0.994
More...
Q08495
Dematin
DEG_SPOP_SBC_1
88:92
PKSTS
SPOP
0.8879
More...
Q14154
DAP3-binding cell death enhancer 1
DEG_SPOP_SBC_1
25:29
PKSTS
SPOP
0.9768
More...
Q5JR59
Microtubule-associated tumor suppressor candidate 2
DEG_SPOP_SBC_1
928:932
PKSTS
SPOP
0.974
More...
Q5T011
KICSTOR complex protein SZT2
DEG_SPOP_SBC_1
2971:2975
PKSTS
SPOP
0.5397
More...
Q8NDX5
Polyhomeotic-like protein 3
DEG_SPOP_SBC_1
234:238
PKSTS
SPOP
0.6925
More...
Q9H808
Transducin-like enhancer protein 6
DEG_SPOP_SBC_1
13:17
PKSTS
SPOP
0.6634
More...
Q9NW75
G patch domain-containing protein 2
DEG_SPOP_SBC_1
513:517
PKSTS
SPOP
0.8361
More...