DegronMD

Uniprot ID: O14939

Source protein: Phospholipase D2

Source gene: PLD2

Class: DEG_SPOP_SBC_1

Location: 583:587

E3 ligase: SPOP

DEGRON score: 0.7698

ASA_SCORE: 63.1

COIL: 0.8344

CONS_SCORE: 0.5334

DSS_SCORE: 0.3376

HELIX: 0.0736

FCONS_SCORE: 1.1989

RIG_SCORE: 0.7553

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S585Y	TCGA-AA-3812	COAD	TCGA	PKSTS	DEG_SPOP_SBC_1	0.712
p.S585Y	DO10655	COAD	ICGC	PKSTS	DEG_SPOP_SBC_1	0.712
p.Y580H	DO230309	COCA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.6944
p.T577I	DO229003	COCA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.1667
p.A589T	DO233276	GACA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.2778
p.P576S	DO229052	LICA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.1389
p.P576S	DO220913	MELA	ICGC	PKSTS	DEG_SPOP_SBC_1	0.1389
p.P593R	ACH-002926	Unknown	CCLE	PKSTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14939	Phospholipase D2	DEG_SPOP_SBC_1	583:587	PKSTS	SPOP	0.7698	More...
O43497	Voltage-dependent T-type calcium channel subunit alpha-1G	DEG_SPOP_SBC_1	1051:1055	PKSTS	SPOP	0.9183	More...
O75132	Zinc finger BED domain-containing protein 4	DEG_SPOP_SBC_1	278:282	PKSTS	SPOP	0.8251	More...
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	861:865	PKSTS	SPOP	0.994	More...
Q08495	Dematin	DEG_SPOP_SBC_1	88:92	PKSTS	SPOP	0.8879	More...
Q14154	DAP3-binding cell death enhancer 1	DEG_SPOP_SBC_1	25:29	PKSTS	SPOP	0.9768	More...
Q5JR59	Microtubule-associated tumor suppressor candidate 2	DEG_SPOP_SBC_1	928:932	PKSTS	SPOP	0.974	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	2971:2975	PKSTS	SPOP	0.5397	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	234:238	PKSTS	SPOP	0.6925	More...
Q9H808	Transducin-like enhancer protein 6	DEG_SPOP_SBC_1	13:17	PKSTS	SPOP	0.6634	More...
Q9NW75	G patch domain-containing protein 2	DEG_SPOP_SBC_1	513:517	PKSTS	SPOP	0.8361	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons