DegronMD

Uniprot ID: Q08495

Source protein: Dematin

Source gene: DMTN

Class: DEG_Kelch_Keap1_1

Location: 223:228

E3 ligase: KEAP1

DEGRON score: 0.6868

ASA_SCORE: 96.8833

COIL: 0.6388

CONS_SCORE: 0.4367

DSS_SCORE: 0.6754

HELIX: 0.363

FCONS_SCORE: 1.0204

RIG_SCORE: 0.6415

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D225N	TCGA-AP-A0LM	UCEC	TCGA	DDDSGE	DEG_Kelch_Keap1_1	0.6932
p.D225N	DO23324	LINC	ICGC	DDDSGE	DEG_Kelch_Keap1_1	0.6932
p.D225N	DO43306	UCEC	ICGC	DDDSGE	DEG_Kelch_Keap1_1	0.6932
p.E218Q	TCGA-UY-A9PH	BLCA	TCGA	DDDSGE	DEG_Kelch_Keap1_1	0.1944
p.E218Q	DO223594	BLCA	ICGC	DDDSGE	DEG_Kelch_Keap1_1	0.1944
p.R236C	SIDM02013	Colorectal Carcinoma	GDSC	DDDSGE	DEG_Kelch_Keap1_1	0.1111
p.R236C	SIDM01169	Ovarian Carcinoma	GDSC	DDDSGE	DEG_Kelch_Keap1_1	0.1111
p.R236C	ACH-000885	Ovarian Cancer	CCLE	DDDSGE	DEG_Kelch_Keap1_1	0.1111
p.R236C	TOV-21G	ovary	COSMIC	DDDSGE	DEG_Kelch_Keap1_1	0.1111
p.E229D	SIDM00353	Other Sarcomas	GDSC	DDDSGE	DEG_Kelch_Keap1_1	0.3056
p.E229D	ACH-000505	Sarcoma	CCLE	DDDSGE	DEG_Kelch_Keap1_1	0.3056
p.E229D	RKN	ovary	COSMIC	DDDSGE	DEG_Kelch_Keap1_1	0.3056
p.G214R	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	DDDSGE	DEG_Kelch_Keap1_1	0.0833
p.G214R	TE-4	oesophagus	COSMIC	DDDSGE	DEG_Kelch_Keap1_1	0.0833
p.M230V	SIDM00537	Colorectal Carcinoma	GDSC	DDDSGE	DEG_Kelch_Keap1_1	0.2778
p.M230V	GP5d	large_intestine	COSMIC	DDDSGE	DEG_Kelch_Keap1_1	0.2778
p.R236H	SIDM01609	Endometrial Carcinoma	GDSC	DDDSGE	DEG_Kelch_Keap1_1	0.1111
p.R236H	ACH-000972	Endometrial/Uterine Cancer	CCLE	DDDSGE	DEG_Kelch_Keap1_1	0.1111
p.R224Q	ACH-000683	Colon/Colorectal Cancer	CCLE	DDDSGE	DEG_Kelch_Keap1_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94983	Calmodulin-binding transcription activator 2	DEG_Kelch_Keap1_1	446:451	DDDSGE	KEAP1	0.9917	More...
Q08495	Dematin	DEG_Kelch_Keap1_1	223:228	DDDSGE	KEAP1	0.6868	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons