DegronMD

Uniprot ID: O94983

Source protein: Calmodulin-binding transcription activator 2

Source gene: CAMTA2

Class: DEG_Kelch_Keap1_1

Location: 446:451

E3 ligase: KEAP1

DEGRON score: 0.9917

ASA_SCORE: 77.5167

COIL: 0.7957

CONS_SCORE: 0.376

DSS_SCORE: 0.7003

HELIX: 0.0628

FCONS_SCORE: 1.0567

RIG_SCORE: 0.6545

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S455L	TCGA-CK-4951	COAD	TCGA	DDDSGE	DEG_Kelch_Keap1_1	0.2222
p.P452T	TCGA-D3-A2J6	SKCM	TCGA	DDDSGE	DEG_Kelch_Keap1_1	0.3056
p.F442L	DO22237	LGG	ICGC	DDDSGE	DEG_Kelch_Keap1_1	0.2222
p.D447N	DO22962	LIHC	ICGC	DDDSGE	DEG_Kelch_Keap1_1	0.5821
p.G450E	DO47317	SKCM	ICGC	DDDSGE	DEG_Kelch_Keap1_1	0.7199
p.N440K	DO41488	UCEC	ICGC	DDDSGE	DEG_Kelch_Keap1_1	0.1667
p.L442P	SIDM01314	Colorectal Carcinoma	GDSC	DDDSGE	DEG_Kelch_Keap1_1	0.2222
p.R449W	SIDM00216	Colorectal Carcinoma	GDSC	DDDSGE	DEG_Kelch_Keap1_1	0.8634
p.R449W	SNU-175	large_intestine	COSMIC	DDDSGE	DEG_Kelch_Keap1_1	0.8634
p.E437Q	SIDM00881	Breast Carcinoma	GDSC	DDDSGE	DEG_Kelch_Keap1_1	0.0833
p.E437Q	HCC1428	breast	COSMIC	DDDSGE	DEG_Kelch_Keap1_1	0.0833
p.P453L	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	DDDSGE	DEG_Kelch_Keap1_1	0.2778
p.P453L	RL	haematopoietic_and_lymphoid_tissue	COSMIC	DDDSGE	DEG_Kelch_Keap1_1	0.2778
p.P452L	SIDM00760	Small Cell Lung Carcinoma	GDSC	DDDSGE	DEG_Kelch_Keap1_1	0.3056
p.P452L	NCI-H1963	lung	COSMIC	DDDSGE	DEG_Kelch_Keap1_1	0.3056
p.D453N	ACH-002381	Non-Cancerous	CCLE	DDDSGE	DEG_Kelch_Keap1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94983	Calmodulin-binding transcription activator 2	DEG_Kelch_Keap1_1	446:451	DDDSGE	KEAP1	0.9917	More...
Q08495	Dematin	DEG_Kelch_Keap1_1	223:228	DDDSGE	KEAP1	0.6868	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons