DegronMD - O94983(CAMTA2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G360A	TCGA-29-1784	OV	TCGA	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation rewiring degron network	0.2222
p.E833K	TCGA-2F-A9KO	BLCA	TCGA	PPSSS	DEG_SPOP_SBC_1	827:831	Mutation rewiring degron network	0.2778
p.T285A	TCGA-2W-A8YY	CESC	TCGA	PSSSS	DEG_SPOP_SBC_1	290:294	Mutation substituting flanking lysine	0.3056
p.R823W	TCGA-98-A53A	LUSC	TCGA	PPSSS	DEG_SPOP_SBC_1	827:831	Mutation rewiring degron network	0.2222
p.A829V	TCGA-A5-A0GB	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	827:831	Mutation altering degron motif	0.6936
p.A829V	ACH-001379	Pancreatic Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	827:831	Mutation altering degron motif	0.6936
p.L521M	TCGA-A5-A1OF	UCEC	TCGA	PAPTPQLS	DEG_SCF_FBW7_1	522:529	Mutation rewiring degron network	0.3056
p.L835P	TCGA-AA-3672	COAD	TCGA	PPSSS	DEG_SPOP_SBC_1	827:831	Mutation rewiring degron network	0.2222
p.P523T	TCGA-AA-A03F	COAD	TCGA	PAPTPQLS	DEG_SCF_FBW7_1	522:529	Mutation altering degron motif	0.7031
p.F524I	TCGA-AP-A051	UCEC	TCGA	PAPTPQLS	DEG_SCF_FBW7_1	522:529	Mutation altering degron motif	0.7415
p.H291Y	TCGA-AP-A059	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	290:294	Mutation altering degron motif	0.7229
p.A281V	TCGA-AP-A059	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.0833
p.R830H	TCGA-AZ-4681	COAD	TCGA	PPSSS	DEG_SPOP_SBC_1	827:831	Mutation altering degron motif	0.8244
p.S841L	TCGA-B5-A0JY	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	827:831	Mutation rewiring degron network	0.0556
p.S841L	TCGA-DF-A2KU	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	827:831	Mutation rewiring degron network	0.0556
p.S841L	DO51871	BLCA	ICGC	PPSSS	DEG_SPOP_SBC_1	827:831	Mutation rewiring degron network	0.0556
p.S455L	TCGA-CK-4951	COAD	TCGA	DDDSGE	DEG_Kelch_Keap1_1	446:451	Mutation rewiring degron network	0.2222
p.G339R	TCGA-CV-7261	HNSC	TCGA	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation rewiring degron network	0.1944
p.P452T	TCGA-D3-A2J6	SKCM	TCGA	DDDSGE	DEG_Kelch_Keap1_1	446:451	Mutation rewiring degron network	0.3056
p.R365G	TCGA-E6-A2P8	UCEC	TCGA	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation rewiring degron network	0.0833
p.P297Q	TCGA-EE-A2MK	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.25
p.S341F	TCGA-EO-A3B0	UCEC	TCGA	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation rewiring degron network	0.25
p.R357L	TCGA-GN-A26C	SKCM	TCGA	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation rewiring degron network	0.3056
p.E833Q	TCGA-K4-A3WU	BLCA	TCGA	PPSSS	DEG_SPOP_SBC_1	827:831	Mutation rewiring degron network	0.2778
p.R823Q	TCGA-VQ-A91D	STAD	TCGA	PPSSS	DEG_SPOP_SBC_1	827:831	Mutation rewiring degron network	0.2222
p.P530Q	TCGA-YG-AA3P	SKCM	TCGA	PAPTPQLS	DEG_SCF_FBW7_1	522:529	Mutation rewiring degron network	0.3056
p.E363G	DO473	BLCA	ICGC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation rewiring degron network	0.1389
p.P519S	DO584	BLCA	ICGC	PAPTPQLS	DEG_SCF_FBW7_1	522:529	Mutation rewiring degron network	0.25
p.S826L	DO225337	BRCA	ICGC	PPSSS	DEG_SPOP_SBC_1	827:831	Mutation rewiring degron network	0.3056
p.M354L	DO227854	BRCA	ICGC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation altering degron motif	0.5999
p.T534S	DO3430	BRCA	ICGC	PAPTPQLS	DEG_SCF_FBW7_1	522:529	Mutation rewiring degron network	0.1944
p.S289F	DO4143	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.3056
p.D833Y	DO8490	COAD	ICGC	PPSSS	DEG_SPOP_SBC_1	827:831	Mutation rewiring degron network	0.2778
p.S293F	DO233797	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	290:294	Mutation altering degron motif	0.9093
p.T362S	DO12100	GBM	ICGC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation rewiring degron network	0.1667
p.S533R	DO219665	KIRP	ICGC	PAPTPQLS	DEG_SCF_FBW7_1	522:529	Mutation rewiring degron network	0.2222
p.F442L	DO22237	LGG	ICGC	DDDSGE	DEG_Kelch_Keap1_1	446:451	Mutation rewiring degron network	0.2222
p.A302V	DO228815	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.1111
p.Q347K	DO228952	LICA	ICGC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation altering degron motif	0.5833
p.D447N	DO22962	LIHC	ICGC	DDDSGE	DEG_Kelch_Keap1_1	446:451	Mutation altering degron motif	0.5821
p.F823C	DO45097	LIRI	ICGC	PPSSS	DEG_SPOP_SBC_1	827:831	Mutation rewiring degron network	0.2222
p.P519L	DO222670	MELA	ICGC	PAPTPQLS	DEG_SCF_FBW7_1	522:529	Mutation rewiring degron network	0.25
p.P519L	DO38057	SKCM	ICGC	PAPTPQLS	DEG_SCF_FBW7_1	522:529	Mutation rewiring degron network	0.25
p.P304T	DO29358	OV	ICGC	PSSSS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.0556
p.G337A	DO28561	OV	ICGC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation rewiring degron network	0.1389
p.S297F	DO219878	SKCA	ICGC	PSSSS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.25
p.T534I	DO37583	SKCM	ICGC	PAPTPQLS	DEG_SCF_FBW7_1	522:529	Mutation rewiring degron network	0.1944
p.R334L	DO37782	SKCM	ICGC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation rewiring degron network	0.0556
p.G450E	DO47317	SKCM	ICGC	DDDSGE	DEG_Kelch_Keap1_1	446:451	Mutation altering degron motif	0.7199
p.G361S	DO38202	STAD	ICGC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation rewiring degron network	0.1944
p.R342G	DO40924	UCEC	ICGC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation rewiring degron network	0.2778
p.S818L	DO223286	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	827:831	Mutation rewiring degron network	0.0833
p.S818L	DO43041	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	827:831	Mutation rewiring degron network	0.0833
p.L825P	DO43090	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	827:831	Mutation rewiring degron network	0.2778
p.S529F	DO41235	UCEC	ICGC	PAPTPQLS	DEG_SCF_FBW7_1	522:529	Mutation altering degron motif	0.7982
p.N440K	DO41488	UCEC	ICGC	DDDSGE	DEG_Kelch_Keap1_1	446:451	Mutation rewiring degron network	0.1667
p.L442P	SIDM01314	Colorectal Carcinoma	GDSC	DDDSGE	DEG_Kelch_Keap1_1	446:451	Mutation rewiring degron network	0.2222
p.R449W	SIDM00216	Colorectal Carcinoma	GDSC	DDDSGE	DEG_Kelch_Keap1_1	446:451	Mutation altering degron motif	0.8634
p.R449W	SNU-175	large intestine	COSMIC	DDDSGE	DEG_Kelch_Keap1_1	446:451	Mutation altering degron motif	0.8634
p.T283A	SIDM00845	Burkitt's Lymphoma	GDSC	PSSSS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.1389
p.T283A	SIDM01519	Head and Neck Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	290:294	Mutation rewiring degron network	0.1389
p.R338Q	SIDM01164	Glioma	GDSC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation rewiring degron network	0.1667
p.R338Q	SW1783	central nervous system	COSMIC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation rewiring degron network	0.1667
p.E437Q	SIDM00881	Breast Carcinoma	GDSC	DDDSGE	DEG_Kelch_Keap1_1	446:451	Mutation rewiring degron network	0.0833
p.E437Q	HCC1428	breast	COSMIC	DDDSGE	DEG_Kelch_Keap1_1	446:451	Mutation rewiring degron network	0.0833
p.P334L	SIDM00272	Breast Carcinoma	GDSC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation rewiring degron network	0.0556
p.P334L	MDA-MB-453	breast	COSMIC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation rewiring degron network	0.0556
p.G514R	SIDM00527	Colorectal Carcinoma	GDSC	PAPTPQLS	DEG_SCF_FBW7_1	522:529	Mutation rewiring degron network	0.1111
p.G514R	MDST8	large intestine	COSMIC	PAPTPQLS	DEG_SCF_FBW7_1	522:529	Mutation rewiring degron network	0.1111
p.C831Y	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PPSSS	DEG_SPOP_SBC_1	827:831	Mutation altering degron motif	0.7087
p.C831Y	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PPSSS	DEG_SPOP_SBC_1	827:831	Mutation altering degron motif	0.7087
p.T362M	SIDM00528	Breast Carcinoma	GDSC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation rewiring degron network	0.1667
p.T362M	MDA-MB-361	breast	COSMIC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation rewiring degron network	0.1667
p.P453L	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	DDDSGE	DEG_Kelch_Keap1_1	446:451	Mutation rewiring degron network	0.2778
p.P453L	RL	haematopoietic and lymphoid tissue	COSMIC	DDDSGE	DEG_Kelch_Keap1_1	446:451	Mutation rewiring degron network	0.2778
p.P452L	SIDM00760	Small Cell Lung Carcinoma	GDSC	DDDSGE	DEG_Kelch_Keap1_1	446:451	Mutation rewiring degron network	0.3056
p.P452L	NCI-H1963	lung	COSMIC	DDDSGE	DEG_Kelch_Keap1_1	446:451	Mutation rewiring degron network	0.3056
p.P355L	ACH-000651	Colon/Colorectal Cancer	CCLE	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation altering degron motif	0.7582
p.P355L	SW620	large intestine	COSMIC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation altering degron motif	0.7582
p.E522K	ACH-000993	Endometrial/Uterine Cancer	CCLE	PAPTPQLS	DEG_SCF_FBW7_1	522:529	Mutation altering degron motif	0.7022
p.P529L	ACH-001786	Colon/Colorectal Cancer	CCLE	PAPTPQLS	DEG_SCF_FBW7_1	522:529	Mutation altering degron motif	0.7582
p.D453N	ACH-002381	Non-Cancerous	CCLE	DDDSGE	DEG_Kelch_Keap1_1	446:451	Mutation rewiring degron network	0.2778
p.T338M	MDA-MB-361	breast	COSMIC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation rewiring degron network	0.1667
p.T344M	MDA-MB-361	breast	COSMIC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation altering degron motif	0.7423
p.P349L	SW620	large intestine	COSMIC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation altering degron motif	0.7582
p.T341M	MDA-MB-361	breast	COSMIC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation rewiring degron network	0.25
p.P352L	SW620	large intestine	COSMIC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation altering degron motif	0.6471
p.T339M	MDA-MB-361	breast	COSMIC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation rewiring degron network	0.1944
p.P350L	SW620	large intestine	COSMIC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	344:356	Mutation altering degron motif	0.6471

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CAMTA2

UniProt ID: O94983

Entrez ID: 23125

Protein name: Calmodulin-binding transcription activator 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CAMTA2 in