DegronMD

Uniprot ID: O94983

Source protein: Calmodulin-binding transcription activator 2

Source gene: CAMTA2

Class: DEG_SCF_FBW7_1

Location: 522:529

E3 ligase: FBXW7

DEGRON score: 0.9594

ASA_SCORE: 85.05

COIL: 0.9466

CONS_SCORE: 0.3791

DSS_SCORE: 0.5344

HELIX: 0.0174

FCONS_SCORE: 0.8734

RIG_SCORE: 0.6759

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L521M	TCGA-A5-A1OF	UCEC	TCGA	PAPTPQLS	DEG_SCF_FBW7_1	0.3056
p.P523T	TCGA-AA-A03F	COAD	TCGA	PAPTPQLS	DEG_SCF_FBW7_1	0.7031
p.F524I	TCGA-AP-A051	UCEC	TCGA	PAPTPQLS	DEG_SCF_FBW7_1	0.7415
p.P530Q	TCGA-YG-AA3P	SKCM	TCGA	PAPTPQLS	DEG_SCF_FBW7_1	0.3056
p.P519S	DO584	BLCA	ICGC	PAPTPQLS	DEG_SCF_FBW7_1	0.25
p.T534S	DO3430	BRCA	ICGC	PAPTPQLS	DEG_SCF_FBW7_1	0.1944
p.S533R	DO219665	KIRP	ICGC	PAPTPQLS	DEG_SCF_FBW7_1	0.2222
p.P519L	DO222670	MELA	ICGC	PAPTPQLS	DEG_SCF_FBW7_1	0.25
p.P519L	DO38057	SKCM	ICGC	PAPTPQLS	DEG_SCF_FBW7_1	0.25
p.T534I	DO37583	SKCM	ICGC	PAPTPQLS	DEG_SCF_FBW7_1	0.1944
p.S529F	DO41235	UCEC	ICGC	PAPTPQLS	DEG_SCF_FBW7_1	0.7982
p.G514R	SIDM00527	Colorectal Carcinoma	GDSC	PAPTPQLS	DEG_SCF_FBW7_1	0.1111
p.G514R	MDST8	large_intestine	COSMIC	PAPTPQLS	DEG_SCF_FBW7_1	0.1111
p.E522K	ACH-000993	Endometrial/Uterine Cancer	CCLE	PAPTPQLS	DEG_SCF_FBW7_1	0.7022
p.P529L	ACH-001786	Colon/Colorectal Cancer	CCLE	PAPTPQLS	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94983	Calmodulin-binding transcription activator 2	DEG_SCF_FBW7_1	522:529	PAPTPQLS	FBXW7	0.9594	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons