DegronMD

Uniprot ID: O94983

Source protein: Calmodulin-binding transcription activator 2

Source gene: CAMTA2

Class: DEG_ODPH_VHL_1

Location: 344:356

E3 ligase: VHL

DEGRON score: 0.7304

ASA_SCORE: 86.2692

COIL: 0.8613

CONS_SCORE: 0.3565

DSS_SCORE: 0.6042

HELIX: 0.0745

FCONS_SCORE: 1.0478

RIG_SCORE: 0.6565

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G360A	TCGA-29-1784	OV	TCGA	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.2222
p.G339R	TCGA-CV-7261	HNSC	TCGA	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.1944
p.R365G	TCGA-E6-A2P8	UCEC	TCGA	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.0833
p.S341F	TCGA-EO-A3B0	UCEC	TCGA	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.25
p.R357L	TCGA-GN-A26C	SKCM	TCGA	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.3056
p.E363G	DO473	BLCA	ICGC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.1389
p.M354L	DO227854	BRCA	ICGC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.5999
p.T362S	DO12100	GBM	ICGC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.1667
p.Q347K	DO228952	LICA	ICGC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.5833
p.G337A	DO28561	OV	ICGC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.1389
p.R334L	DO37782	SKCM	ICGC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.0556
p.G361S	DO38202	STAD	ICGC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.1944
p.R342G	DO40924	UCEC	ICGC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.2778
p.R338Q	SIDM01164	Glioma	GDSC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.1667
p.R338Q	SW1783	central_nervous_system	COSMIC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.1667
p.P334L	SIDM00272	Breast Carcinoma	GDSC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.0556
p.P334L	MDA-MB-453	breast	COSMIC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.0556
p.T362M	SIDM00528	Breast Carcinoma	GDSC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.1667
p.T362M	MDA-MB-361	breast	COSMIC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.1667
p.P355L	ACH-000651	Colon/Colorectal Cancer	CCLE	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.7582
p.P355L	SW620	large_intestine	COSMIC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.7582
p.T338M	MDA-MB-361	breast	COSMIC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.1667
p.T344M	MDA-MB-361	breast	COSMIC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.7423
p.P349L	SW620	large_intestine	COSMIC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.7582
p.T341M	MDA-MB-361	breast	COSMIC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.25
p.P352L	SW620	large_intestine	COSMIC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.6471
p.T339M	MDA-MB-361	breast	COSMIC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.1944
p.P350L	SW620	large_intestine	COSMIC	LAPQADPRPSMSL	DEG_ODPH_VHL_1	0.6471

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPQADPRPSMSL

Degron related mutations and impact score

Drug responses associated with CAMTA2 mutations

All proteins holding degron of LAPQADPRPSMSL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94983	Calmodulin-binding transcription activator 2	DEG_ODPH_VHL_1	344:356	LAPQADPRPSMSL	VHL	0.7304	More...