DegronMD

Uniprot ID: Q08495

Source protein: Dematin

Source gene: DMTN

Class: ITCH

Location: 144:147

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9997

ASA_SCORE: 79.15

COIL: 0.8525

CONS_SCORE: 0.6687

DSS_SCORE: 0.6371

HELIX: 0.0525

FCONS_SCORE: 1.2835

RIG_SCORE: 0.7326

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V153M	TCGA-29-1783	OV	TCGA	PPIY	ITCH	0.1667
p.V153M	DO28222	OV	ICGC	PPIY	ITCH	0.1667
p.V153M	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPIY	ITCH	0.1667
p.V153M	SU-DHL-4	haematopoietic_and_lymphoid_tissue	COSMIC	PPIY	ITCH	0.1667
p.P145L	TCGA-HT-7677	LGG	TCGA	PPIY	ITCH	0.7582
p.P145L	DO22283	LGG	ICGC	PPIY	ITCH	0.7582
p.G154R	DO231958	LICA	ICGC	PPIY	ITCH	0.1389
p.P144R	DO230942	LUSC	ICGC	PPIY	ITCH	0.7512
p.P144R	DO224589	LUSC	ICGC	PPIY	ITCH	0.7512
p.P136Q	DO229164	NKTL	ICGC	PPIY	ITCH	0.1111
p.N142K	ACH-000087	Bone Cancer	CCLE	PPIY	ITCH	0.2778
p.N142K	SK-ES-1	bone	COSMIC	PPIY	ITCH	0.2778
p.A135S	ACH-000760	Brain Cancer	CCLE	PPIY	ITCH	0.0833
p.T134A	NCI-SNU-1	stomach	COSMIC	PPIY	ITCH	0.0556
p.T134A	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	PPIY	ITCH	0.0556
p.N157K	SK-ES-1	bone	COSMIC	PPIY	ITCH	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14639	Actin-binding LIM protein 1	ITCH	525:528	PPIY	ITCH,NEDD4	0.9688	More...
O43281	Embryonal Fyn-associated substrate	ITCH	214:217	PPIY	ITCH,NEDD4	0.6414	More...
O94929	Actin-binding LIM protein 3	ITCH	444:447	PPIY	ITCH,NEDD4	0.9628	More...
Q08495	Dematin	ITCH	144:147	PPIY	ITCH,NEDD4	0.9997	More...
Q15303	Receptor tyrosine-protein kinase erbB-4	ITCH	1032:1035	PPIY	ITCH,NEDD4	0.9911	More...
Q5TC82	Roquin-1	ITCH	663:666	PPIY	ITCH,NEDD4	0.9994	More...
Q6H8Q1	Actin-binding LIM protein 2	ITCH	435:438	PPIY	ITCH,NEDD4	0.9984	More...
Q9NZR2	Low-density lipoprotein receptor-related protein 1B	ITCH	4538:4541	PPIY	ITCH,NEDD4	0.9665	More...
Q9Y2H6	Fibronectin type-III domain-containing protein 3A	ITCH	73:76	PPIY	ITCH,NEDD4	0.947	More...
Q6BDS2	UHRF1-binding protein 1	ITCH	1331:1334	PPIY	ITCH,NEDD4	0.9895	More...
Q9BRJ2	39S ribosomal protein L45, mitochondrial	ITCH	43:46	PPIY	ITCH,NEDD4	0.9042	More...
Q8IXT5	RNA-binding protein 12B	ITCH	516:519	PPIY	ITCH,NEDD4	0.9914	More...
A6NJJ6	UPF0575 protein C19orf67	ITCH	147:150	PPIY	ITCH,NEDD4	0.9135	More...
Q5VZQ5	Testis-expressed protein 36	ITCH	53:56	PPIY	ITCH,NEDD4	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons