DegronMD - Q8IXT5(RBM12B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R528I	TCGA-B5-A0JY	UCEC	TCGA	FRHQLEDLR	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.8102
p.R528I	TCGA-B5-A1MR	UCEC	TCGA	FRHQLEDLR	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.8102
p.R528I	DO43041	UCEC	ICGC	FRHQLEDLR	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.8102
p.R528I	DO41758	UCEC	ICGC	FRHQLEDLR	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.8102
p.H507N	TCGA-D5-6530	COAD	TCGA	PPIY	ITCH	516:519	Mutation rewiring degron network	0.0833
p.H507N	DO8312	COAD	ICGC	PPIY	ITCH	516:519	Mutation rewiring degron network	0.0833
p.D538H	TCGA-E1-5307	LGG	TCGA	FRHQLEDLR	DEG_APCC_DBOX_1	527:535	Mutation rewiring degron network	0.25
p.D538H	DO22359	LGG	ICGC	FRHQLEDLR	DEG_APCC_DBOX_1	527:535	Mutation rewiring degron network	0.25
p.I518V	TCGA-RW-A680	PCPG	TCGA	PPIY	ITCH	516:519	Mutation altering degron motif	0.5965
p.R528K	DO229052	LICA	ICGC	FRHQLEDLR	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.7237
p.R528S	DO222402	MELA	ICGC	FRHQLEDLR	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.7427
p.D533E	SIDM00376	B-Lymphoblastic Leukemia	GDSC	FRHQLEDLR	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.5647
p.D533E	ACH-000156	Leukemia	CCLE	FRHQLEDLR	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.5647
p.D533E	MHH-CALL-4	haematopoietic and lymphoid tissue	COSMIC	FRHQLEDLR	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.5647
p.F527V	SIDM00282	Colorectal Carcinoma	GDSC	FRHQLEDLR	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.5957
p.F527V	ACH-000998	Colon/Colorectal Cancer	CCLE	FRHQLEDLR	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.5957
p.F527V	CW-2	large intestine	COSMIC	FRHQLEDLR	DEG_APCC_DBOX_1	527:535	Mutation altering degron motif	0.5957

Kaplan plot for RBM12B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBM12B

UniProt ID: Q8IXT5

Entrez ID: 389677

Protein name: RNA-binding protein 12B (RNA-binding motif protein 12B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBM12B in