DegronMD

Uniprot ID: Q8IXT5

Source protein: RNA-binding protein 12B

Source gene: RBM12B

Class: DEG_APCC_DBOX_1

Location: 527:535

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8728

ASA_SCORE: 96.4333

COIL: 0.4154

CONS_SCORE: 0.4945

DSS_SCORE: 0.4305

HELIX: 0.5443

FCONS_SCORE: 1.1734

RIG_SCORE: 0.7838

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R528I	TCGA-B5-A0JY	UCEC	TCGA	FRHQLEDLR	DEG_APCC_DBOX_1	0.8102
p.R528I	TCGA-B5-A1MR	UCEC	TCGA	FRHQLEDLR	DEG_APCC_DBOX_1	0.8102
p.R528I	DO43041	UCEC	ICGC	FRHQLEDLR	DEG_APCC_DBOX_1	0.8102
p.R528I	DO41758	UCEC	ICGC	FRHQLEDLR	DEG_APCC_DBOX_1	0.8102
p.D538H	TCGA-E1-5307	LGG	TCGA	FRHQLEDLR	DEG_APCC_DBOX_1	0.25
p.D538H	DO22359	LGG	ICGC	FRHQLEDLR	DEG_APCC_DBOX_1	0.25
p.R528K	DO229052	LICA	ICGC	FRHQLEDLR	DEG_APCC_DBOX_1	0.7237
p.R528S	DO222402	MELA	ICGC	FRHQLEDLR	DEG_APCC_DBOX_1	0.7427
p.D533E	SIDM00376	B-Lymphoblastic Leukemia	GDSC	FRHQLEDLR	DEG_APCC_DBOX_1	0.5647
p.D533E	ACH-000156	Leukemia	CCLE	FRHQLEDLR	DEG_APCC_DBOX_1	0.5647
p.D533E	MHH-CALL-4	haematopoietic_and_lymphoid_tissue	COSMIC	FRHQLEDLR	DEG_APCC_DBOX_1	0.5647
p.F527V	SIDM00282	Colorectal Carcinoma	GDSC	FRHQLEDLR	DEG_APCC_DBOX_1	0.5957
p.F527V	ACH-000998	Colon/Colorectal Cancer	CCLE	FRHQLEDLR	DEG_APCC_DBOX_1	0.5957
p.F527V	CW-2	large_intestine	COSMIC	FRHQLEDLR	DEG_APCC_DBOX_1	0.5957

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXT5	RNA-binding protein 12B	DEG_APCC_DBOX_1	527:535	FRHQLEDLR	APC,CDC20,FZR1	0.8728	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons