DegronMD - Q6BDS2(UHRF1BP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K1327N	TCGA-AX-A06F	UCEC	TCGA	PPIY	ITCH	1331:1334	Mutation substituting flanking lysine	0.3333
p.K1327N	DO41752	UCEC	ICGC	PPIY	ITCH	1331:1334	Mutation substituting flanking lysine	0.3333
p.G1339D	TCGA-F4-6856	COAD	TCGA	PPIY	ITCH	1331:1334	Mutation rewiring degron network	0.1944
p.G1339D	DO9114	COAD	ICGC	PPIY	ITCH	1331:1334	Mutation rewiring degron network	0.1944
p.G1339S	TCGA-FR-A726	SKCM	TCGA	PPIY	ITCH	1331:1334	Mutation rewiring degron network	0.1944
p.G1339S	DO48665	SKCM	ICGC	PPIY	ITCH	1331:1334	Mutation rewiring degron network	0.1944
p.S1337C	TCGA-ZF-AA4X	BLCA	TCGA	PPIY	ITCH	1331:1334	Mutation rewiring degron network	0.25
p.S1337C	DO219091	BLCA	ICGC	PPIY	ITCH	1331:1334	Mutation rewiring degron network	0.25
p.I1324V	DO48270	ESCA	ICGC	PPIY	ITCH	1331:1334	Mutation rewiring degron network	0.1389
p.G1339V	DO229029	LICA	ICGC	PPIY	ITCH	1331:1334	Mutation rewiring degron network	0.1944
p.D1329N	DO229257	THCA	ICGC	PPIY	ITCH	1331:1334	Mutation rewiring degron network	0.2778
p.T1336I	SIDM00290	Gastric Carcinoma	GDSC	PPIY	ITCH	1331:1334	Mutation blocking phosphorylation signal	0.7222
p.T1336I	SIDM00989	Bladder Carcinoma	GDSC	PPIY	ITCH	1331:1334	Mutation blocking phosphorylation signal	0.7222
p.T1336I	SIDM01471	Chronic Myelogenous Leukemia	GDSC	PPIY	ITCH	1331:1334	Mutation blocking phosphorylation signal	0.7222
p.T1336I	HGC-27	stomach	COSMIC	PPIY	ITCH	1331:1334	Mutation blocking phosphorylation signal	0.7222
p.T1336I	BFTC-905	urinary tract	COSMIC	PPIY	ITCH	1331:1334	Mutation blocking phosphorylation signal	0.7222
p.Y1334C	ACH-000196	Breast Cancer	CCLE	PPIY	ITCH	1331:1334	Mutation altering degron motif	0.7087

Kaplan plot for UHRF1BP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UHRF1BP1

UniProt ID: Q6BDS2

Entrez ID: 54887

Protein name: UHRF1-binding protein 1 (ICBP90-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UHRF1BP1 in