DegronMD - Q6H8Q1(ABLIM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S292L	TCGA-A8-A08H	BRCA	TCGA	PASST	DEG_SPOP_SBC_1	287:291	Mutation blocking phosphorylation signal	0.75
p.S292L	DO5563	BRCA	ICGC	PASST	DEG_SPOP_SBC_1	287:291	Mutation blocking phosphorylation signal	0.75
p.D489N	TCGA-AB-2806	LAML	TCGA	DRDPLQRMA	DEG_APCC_DBOX_1	491:499	Mutation rewiring degron network	0.2778
p.E425D	TCGA-AP-A1DK	UCEC	TCGA	PPIY	ITCH	435:438	Mutation blocking phosphorylation signal	0.5
p.D438N	TCGA-BT-A2LB	BLCA	TCGA	PPIY	ITCH	435:438	Mutation altering degron motif	0.6932
p.D438H	TCGA-CN-5369	HNSC	TCGA	PPIY	ITCH	435:438	Mutation altering degron motif	0.7688
p.P443S	TCGA-EB-A5FP	SKCM	TCGA	PPIY	ITCH	435:438	Mutation rewiring degron network	0.1944
p.P443S	TCGA-EE-A29D	SKCM	TCGA	PPIY	ITCH	435:438	Mutation rewiring degron network	0.1944
p.P443L	TCGA-EE-A29D	SKCM	TCGA	PPIY	ITCH	435:438	Mutation rewiring degron network	0.1944
p.R491S	TCGA-EO-A3B0	UCEC	TCGA	DRDPLQRMA	DEG_APCC_DBOX_1	491:499	Mutation altering degron motif	0.7427
p.L486V	TCGA-EO-A3B0	UCEC	TCGA	DRDPLQRMA	DEG_APCC_DBOX_1	491:499	Mutation rewiring degron network	0.1944
p.D503N	TCGA-ER-A19P	SKCM	TCGA	DRDPLQRMA	DEG_APCC_DBOX_1	491:499	Mutation rewiring degron network	0.2222
p.V435M	TCGA-FI-A2D0	UCEC	TCGA	PPIY	ITCH	435:438	Mutation altering degron motif	0.7208
p.V435A	TCGA-FI-A2D5	UCEC	TCGA	PPIY	ITCH	435:438	Mutation altering degron motif	0.6936
p.S285F	TCGA-FW-A3TV	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.2778
p.S285F	DO38159	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.2778
p.K494R	TCGA-GN-A4U4	SKCM	TCGA	DRDPLQRMA	DEG_APCC_DBOX_1	491:499	Mutation altering degron motif	0.7237
p.L500P	TCGA-HU-A4GY	STAD	TCGA	DRDPLQRMA	DEG_APCC_DBOX_1	491:499	Mutation rewiring degron network	0.3056
p.D440N	DO234194	ESAD	ICGC	PPIY	ITCH	435:438	Mutation rewiring degron network	0.2778
p.G426D	DO20827	KIRP	ICGC	PPIY	ITCH	435:438	Mutation rewiring degron network	0.0833
p.T425S	DO228278	LICA	ICGC	PPIY	ITCH	435:438	Mutation blocking phosphorylation signal	0.5
p.R433G	DO231835	LINC	ICGC	PPIY	ITCH	435:438	Mutation rewiring degron network	0.2778
p.S436F	DO51962	PRAD	ICGC	PPIY	ITCH	435:438	Mutation altering degron motif	0.7982
p.S436F	DO37814	SKCM	ICGC	PPIY	ITCH	435:438	Mutation altering degron motif	0.7982
p.A442S	DO37831	SKCM	ICGC	PPIY	ITCH	435:438	Mutation rewiring degron network	0.2222
p.A442S	DO47578	SKCM	ICGC	PPIY	ITCH	435:438	Mutation rewiring degron network	0.2222
p.R433M	DO37444	SKCM	ICGC	PPIY	ITCH	435:438	Mutation rewiring degron network	0.2778
p.D429N	DO47623	SKCM	ICGC	PPIY	ITCH	435:438	Mutation rewiring degron network	0.1667
p.S443F	DO223907	SKCM	ICGC	PPIY	ITCH	435:438	Mutation rewiring degron network	0.1944
p.S443F	DO51281	SKCM	ICGC	PPIY	ITCH	435:438	Mutation rewiring degron network	0.1944
p.L426P	DO47901	STAD	ICGC	PPIY	ITCH	435:438	Mutation rewiring degron network	0.0833
p.R428W	SIDM00084	Glioblastoma	GDSC	PPIY	ITCH	435:438	Mutation substituting flanking lysine	0.25
p.P295L	SIDM00887	Other Solid Cancers	GDSC	PASST	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.2222
p.P295L	Daoy	central nervous system	COSMIC	PASST	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.2222
p.D493N	ACH-000768	Breast Cancer	CCLE	DRDPLQRMA	DEG_APCC_DBOX_1	491:499	Mutation altering degron motif	0.5821
p.G481E	ACH-001982	Metastasis	CCLE	DRDPLQRMA	DEG_APCC_DBOX_1	491:499	Mutation blocking phosphorylation signal	0.5
p.T481I	C-33-A	cervix	COSMIC	DRDPLQRMA	DEG_APCC_DBOX_1	491:499	Mutation blocking phosphorylation signal	0.5
p.P485S	EFO-27	ovary	COSMIC	DRDPLQRMA	DEG_APCC_DBOX_1	491:499	Mutation rewiring degron network	0.1667
p.R445Q	SNU-283	large intestine	COSMIC	PPIY	ITCH	435:438	Mutation rewiring degron network	0.1389
p.R509C	SNU-81	large intestine	COSMIC	DRDPLQRMA	DEG_APCC_DBOX_1	491:499	Mutation rewiring degron network	0.0556
p.P441L	Sarc9371	bone	COSMIC	PPIY	ITCH	435:438	Mutation rewiring degron network	0.25
p.T441I	C-33-A	cervix	COSMIC	PPIY	ITCH	435:438	Mutation rewiring degron network	0.25
p.T430I	C-33-A	cervix	COSMIC	PPIY	ITCH	435:438	Mutation rewiring degron network	0.1944
p.T440I	C-33-A	cervix	COSMIC	PPIY	ITCH	435:438	Mutation rewiring degron network	0.2778
p.T429I	C-33-A	cervix	COSMIC	PPIY	ITCH	435:438	Mutation rewiring degron network	0.1667
p.P444L	H3118	upper aerodigestive tract	COSMIC	PPIY	ITCH	435:438	Mutation rewiring degron network	0.1667
p.R296C	SNU-81	large intestine	COSMIC	PASST	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.1944
p.R481C	SNU-81	large intestine	COSMIC	DRDPLQRMA	DEG_APCC_DBOX_1	491:499	Mutation blocking phosphorylation signal	0.5
p.P300S	EFO-27	ovary	COSMIC	PASST	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ABLIM2

UniProt ID: Q6H8Q1

Entrez ID: 84448

Protein name: Actin-binding LIM protein 2 (abLIM-2) (Actin-binding LIM protein family member 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ABLIM2 in