DegronMD

Uniprot ID: Q6H8Q1

Source protein: Actin-binding LIM protein 2

Source gene: ABLIM2

Class: DEG_APCC_DBOX_1

Location: 491:499

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7824

ASA_SCORE: 86.5333

COIL: 0.7203

CONS_SCORE: 0.414

DSS_SCORE: 0.6845

HELIX: 0.2257

FCONS_SCORE: 0.9757

RIG_SCORE: 0.6491

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D489N	TCGA-AB-2806	LAML	TCGA	DRDPLQRMA	DEG_APCC_DBOX_1	0.2778
p.R491S	TCGA-EO-A3B0	UCEC	TCGA	DRDPLQRMA	DEG_APCC_DBOX_1	0.7427
p.L486V	TCGA-EO-A3B0	UCEC	TCGA	DRDPLQRMA	DEG_APCC_DBOX_1	0.1944
p.D503N	TCGA-ER-A19P	SKCM	TCGA	DRDPLQRMA	DEG_APCC_DBOX_1	0.2222
p.K494R	TCGA-GN-A4U4	SKCM	TCGA	DRDPLQRMA	DEG_APCC_DBOX_1	0.7237
p.L500P	TCGA-HU-A4GY	STAD	TCGA	DRDPLQRMA	DEG_APCC_DBOX_1	0.3056
p.D493N	ACH-000768	Breast Cancer	CCLE	DRDPLQRMA	DEG_APCC_DBOX_1	0.5821
p.G481E	ACH-001982	Metastasis	CCLE	DRDPLQRMA	DEG_APCC_DBOX_1	0.5
p.T481I	C-33-A	cervix	COSMIC	DRDPLQRMA	DEG_APCC_DBOX_1	0.5
p.P485S	EFO-27	ovary	COSMIC	DRDPLQRMA	DEG_APCC_DBOX_1	0.1667
p.R509C	SNU-81	large_intestine	COSMIC	DRDPLQRMA	DEG_APCC_DBOX_1	0.0556
p.R481C	SNU-81	large_intestine	COSMIC	DRDPLQRMA	DEG_APCC_DBOX_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6H8Q1	Actin-binding LIM protein 2	DEG_APCC_DBOX_1	491:499	DRDPLQRMA	APC,CDC20,FZR1	0.7824	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons