DegronMD

Uniprot ID: Q15303

Source protein: Receptor tyrosine-protein kinase erbB-4

Source gene: ERBB4

Class: ITCH

Location: 1053:1056

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9956

ASA_SCORE: 72.7

COIL: 0.8753

CONS_SCORE: 0.3027

DSS_SCORE: 0.5786

HELIX: 0.04

FCONS_SCORE: 1.0398

RIG_SCORE: 0.6259

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1043L	TCGA-AP-A056	UCEC	TCGA	PPAY	ITCH	0.5
p.S1043L	TCGA-BK-A6W3	UCEC	TCGA	PPAY	ITCH	0.5
p.I1048T	TCGA-CA-6717	COAD	TCGA	PPAY	ITCH	0.1944
p.Q1063K	TCGA-CD-A48A	STAD	TCGA	PPAY	ITCH	0.1389
p.N1062H	TCGA-CN-6024	HNSC	TCGA	PPAY	ITCH	0.1667
p.P1054H	TCGA-CW-6093	KIRC	TCGA	PPAY	ITCH	0.7694
p.E1047K	TCGA-EE-A3AA	SKCM	TCGA	PPAY	ITCH	0.1667
p.P1053L	TCGA-ER-A42L	SKCM	TCGA	PPAY	ITCH	0.7582
p.N1044D	TCGA-IB-7651	PAAD	TCGA	PPAY	ITCH	0.0833
p.G1066E	DO223594	BLCA	ICGC	PPAY	ITCH	0.5
p.Y1056H	DO229363	BTCA	ICGC	PPAY	ITCH	0.834
p.A1045T	DO227993	COCA	ICGC	PPAY	ITCH	0.1111
p.E1064D	DO223095	ESCA	ICGC	PPAY	ITCH	0.1111
p.N1052H	DO15326	HNSC	ICGC	PPAY	ITCH	0.3056
p.P1044H	DO16248	KIRC	ICGC	PPAY	ITCH	0.0833
p.Q1053K	DO220858	MELA	ICGC	PPAY	ITCH	0.6944
p.Q1053K	DO47781	STAD	ICGC	PPAY	ITCH	0.6944
p.G1060S	DO220877	MELA	ICGC	PPAY	ITCH	0.2222
p.G1059E	DO229459	SKCA	ICGC	PPAY	ITCH	0.25
p.P1043L	DO223910	SKCM	ICGC	PPAY	ITCH	0.5
p.G1060C	DO42713	UCEC	ICGC	PPAY	ITCH	0.2222
p.G1049E	SIDM01248	Thyroid Gland Carcinoma	GDSC	PPAY	ITCH	0.2222
p.G1049E	ACH-001023	Thyroid Cancer	CCLE	PPAY	ITCH	0.2222
p.G1049E	CGTH-W-1	thyroid	COSMIC	PPAY	ITCH	0.2222
p.P1058R	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	PPAY	ITCH	0.2778
p.P1058R	ACH-002263	Esophageal Cancer	CCLE	PPAY	ITCH	0.2778
p.P1058R	KYSE-220	oesophagus	COSMIC	PPAY	ITCH	0.2778
p.R1045G	SIDM00693	Bladder Carcinoma	GDSC	PPAY	ITCH	0.1111
p.R1045G	ACH-000396	Bladder Cancer	CCLE	PPAY	ITCH	0.1111
p.R1045G	J82	urinary_tract	COSMIC	PPAY	ITCH	0.1111
p.N1062S	SIDM00500	Colorectal Carcinoma	GDSC	PPAY	ITCH	0.1667
p.N1044S	ACH-000611	Lymphoma	CCLE	PPAY	ITCH	0.0833
p.N1062K	ACH-001366	Neuroblastoma	CCLE	PPAY	ITCH	0.1667
p.Y1065N	NCC010	kidney	COSMIC	PPAY	ITCH	0.0833
p.E1048D	Hs766T	pancreas	COSMIC	PPAY	ITCH	0.1944
p.E1058D	NCI-H2029	lung	COSMIC	PPAY	ITCH	0.2778
p.G1053V	SNU-1040	large_intestine	COSMIC	PPAY	ITCH	0.7532
p.E1058V	REH	haematopoietic_and_lymphoid_tissue	COSMIC	PPAY	ITCH	0.2778

Drug responses associated with ERBB4 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G668V (No)	GDSC	CI-1033	625.7219
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G668V (No)	GDSC	PF-00299804	634.8413
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G668V (No)	GDSC	AST-1306	607.8213
SIDM01228	SKCM\|melanoma	p.A1083V (No)	GDSC	CI-1033	0.3935
SIDM01228	SKCM\|melanoma	p.A1083V (No)	GDSC	PF-00299804	0.1643
SIDM01228	SKCM\|melanoma	p.A1083V (No)	GDSC	AST-1306	0.2247
SIDM01228	SKCM\|melanoma	p.C945F (No)	GDSC	CI-1033	0.3935
SIDM01228	SKCM\|melanoma	p.C945F (No)	GDSC	PF-00299804	0.1643
SIDM01228	SKCM\|melanoma	p.C945F (No)	GDSC	AST-1306	0.2247
SIDM00951	LAML\|acute_myeloid_leukaemia	p.G863E (No)	GDSC	CI-1033	1.6259
SIDM00951	LAML\|acute_myeloid_leukaemia	p.G863E (No)	GDSC	PF-00299804	0.9758
SIDM00951	LAML\|acute_myeloid_leukaemia	p.G863E (No)	GDSC	AST-1306	4.8215
SIDM00213	THCA\|thyroid	p.V748L (No)	GDSC	CI-1033	11.7349
SIDM00213	THCA\|thyroid	p.V748L (No)	GDSC	PF-00299804	20.7714
SIDM00213	THCA\|thyroid	p.V748L (No)	GDSC	AST-1306	11.4067
SIDM00680	COREAD\|large_intestine	p.V553E (No)	GDSC	CI-1033	7.6901
SIDM00680	COREAD\|large_intestine	p.V553E (No)	GDSC	PF-00299804	6.6906
SIDM00680	COREAD\|large_intestine	p.V553E (No)	GDSC	AST-1306	8.6121
SIDM00145	ALL\|lymphoblastic_leukemia	p.A287T (No)	GDSC	CI-1033	4.9765
SIDM00145	ALL\|lymphoblastic_leukemia	p.A287T (No)	GDSC	PF-00299804	2.5703
SIDM00145	ALL\|lymphoblastic_leukemia	p.A287T (No)	GDSC	AST-1306	5.3078
SIDM00661	DLBC\|B_cell_lymphoma	p.T639A (No)	GDSC	CI-1033	12.0365
SIDM00661	DLBC\|B_cell_lymphoma	p.T639A (No)	GDSC	PF-00299804	4.0679
SIDM00661	DLBC\|B_cell_lymphoma	p.T639A (No)	GDSC	AST-1306	5.0729
SIDM00683	PRAD\|prostate	p.Q1126* (No)	GDSC	CI-1033	13.1536
SIDM00683	PRAD\|prostate	p.Q1126* (No)	GDSC	PF-00299804	13.0157
SIDM00683	PRAD\|prostate	p.Q1126* (No)	GDSC	AST-1306	27.4993
SIDM00351	HNSC\|head_and_neck	p.G1109C (No)	GDSC	CI-1033	280.2049
SIDM00351	HNSC\|head_and_neck	p.G1109C (No)	GDSC	PF-00299804	172.5797
SIDM00351	HNSC\|head_and_neck	p.G1109C (No)	GDSC	AST-1306	251.9199
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.G107V (No)	GDSC	CI-1033	52.3177
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.G107V (No)	GDSC	PF-00299804	9.1914
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.G107V (No)	GDSC	AST-1306	9.9412
SIDM01007	ALL\|lymphoblastic_leukemia	p.I119T (No)	GDSC	CI-1033	3.0971
SIDM01007	ALL\|lymphoblastic_leukemia	p.I119T (No)	GDSC	PF-00299804	1.6503
SIDM01007	ALL\|lymphoblastic_leukemia	p.I119T (No)	GDSC	AST-1306	3.0199
SIDM00664	PAAD\|pancreas	p.E1090D (No)	GDSC	CI-1033	121.4984
SIDM00664	PAAD\|pancreas	p.E1090D (No)	GDSC	PF-00299804	77.9236
SIDM00664	PAAD\|pancreas	p.E1090D (No)	GDSC	AST-1306	13.6513
SIDM01009	NB\|neuroblastoma	p.P386S (No)	GDSC	CI-1033	5.1399
SIDM01009	NB\|neuroblastoma	p.P386S (No)	GDSC	PF-00299804	2.2239
SIDM01009	NB\|neuroblastoma	p.P386S (No)	GDSC	AST-1306	3.9816
SIDM00214	COREAD\|large_intestine	p.R1250W (No)	GDSC	CI-1033	16.3474
SIDM00214	COREAD\|large_intestine	p.R1250W (No)	GDSC	PF-00299804	16.5693
SIDM00214	COREAD\|large_intestine	p.R1250W (No)	GDSC	AST-1306	13.2789
SIDM01088	UNCLASSIFIED\|endometrium	p.D960Y (No)	GDSC	CI-1033	1.8076
SIDM01088	UNCLASSIFIED\|endometrium	p.D960Y (No)	GDSC	PF-00299804	0.8176
SIDM01088	UNCLASSIFIED\|endometrium	p.D960Y (No)	GDSC	AST-1306	0.4803
SIDM00938	BRCA\|breast	p.M250I (No)	GDSC	CI-1033	3.2379
SIDM00938	BRCA\|breast	p.M250I (No)	GDSC	PF-00299804	8.513
SIDM00938	BRCA\|breast	p.M250I (No)	GDSC	AST-1306	3.0479
SIDM00003	SKCM\|melanoma	p.E317D (No)	GDSC	CI-1033	12.5763
SIDM00003	SKCM\|melanoma	p.E317D (No)	GDSC	PF-00299804	21.7285
SIDM00003	SKCM\|melanoma	p.E317D (No)	GDSC	AST-1306	7.7801
SIDM00551	ESCA\|oesophagus	p.P1058R (Yes)	GDSC	CI-1033	2.4348
SIDM00551	ESCA\|oesophagus	p.P1058R (Yes)	GDSC	PF-00299804	1.3046
SIDM00551	ESCA\|oesophagus	p.P1058R (Yes)	GDSC	AST-1306	2.5895
SIDM01197	COREAD\|large_intestine	p.S227N (No)	GDSC	CI-1033	1228.0969
SIDM01197	COREAD\|large_intestine	p.S227N (No)	GDSC	PF-00299804	118.7014
SIDM01197	COREAD\|large_intestine	p.S227N (No)	GDSC	AST-1306	35.2199
SIDM01039	UNCLASSIFIED\|urogenital_system_other	p.L1285P (No)	GDSC	CI-1033	10.5003
SIDM01039	UNCLASSIFIED\|urogenital_system_other	p.L1285P (No)	GDSC	PF-00299804	8.0399
SIDM01039	UNCLASSIFIED\|urogenital_system_other	p.L1285P (No)	GDSC	AST-1306	7.928
SIDM00619	THCA\|thyroid	p.M562L (No)	GDSC	CI-1033	2.2569
SIDM00619	THCA\|thyroid	p.M562L (No)	GDSC	PF-00299804	1.5015
SIDM00619	THCA\|thyroid	p.M562L (No)	GDSC	AST-1306	0.2762
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.R114Q (No)	GDSC	CI-1033	3.9782
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.R114Q (No)	GDSC	PF-00299804	4.7819
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.R114Q (No)	GDSC	AST-1306	3.6829
SIDM00770	SCLC\|lung_small_cell_carcinoma	p.I827R (No)	GDSC	CI-1033	10.1065
SIDM00770	SCLC\|lung_small_cell_carcinoma	p.I827R (No)	GDSC	PF-00299804	19.2743
SIDM00770	SCLC\|lung_small_cell_carcinoma	p.I827R (No)	GDSC	AST-1306	10.7208
SIDM00333	UCEC\|endometrium	p.A978T (No)	GDSC	CI-1033	9.3187
SIDM00333	UCEC\|endometrium	p.A978T (No)	GDSC	PF-00299804	4.5029
SIDM00333	UCEC\|endometrium	p.A978T (No)	GDSC	AST-1306	4.1386
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.L74H (No)	GDSC	CI-1033	14.0918
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.L74H (No)	GDSC	PF-00299804	2.9404
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.L74H (No)	GDSC	AST-1306	4.7326
SIDM00401	SKCM\|melanoma	p.A4E (No)	GDSC	CI-1033	4.6485
SIDM00401	SKCM\|melanoma	p.A4E (No)	GDSC	PF-00299804	9.6739
SIDM00401	SKCM\|melanoma	p.A4E (No)	GDSC	AST-1306	5.7254
SIDM00600	THCA\|thyroid	p.T716S (No)	GDSC	CI-1033	3.444
SIDM00600	THCA\|thyroid	p.T716S (No)	GDSC	PF-00299804	2.3879
SIDM00600	THCA\|thyroid	p.T716S (No)	GDSC	AST-1306	0.6832
SIDM00489	HNSC\|head_and_neck	p.P854L (No)	GDSC	CI-1033	2.5945
SIDM00489	HNSC\|head_and_neck	p.P854L (No)	GDSC	PF-00299804	7.3201
SIDM00489	HNSC\|head_and_neck	p.P854L (No)	GDSC	AST-1306	0.4299
SIDM00217	COREAD\|large_intestine	p.T1264I (No)	GDSC	CI-1033	8.0923
SIDM00217	COREAD\|large_intestine	p.T1264I (No)	GDSC	PF-00299804	5.4442
SIDM00217	COREAD\|large_intestine	p.T1264I (No)	GDSC	AST-1306	4.4781
SIDM00217	COREAD\|large_intestine	p.G1069V (No)	GDSC	CI-1033	8.0923
SIDM00217	COREAD\|large_intestine	p.G1069V (No)	GDSC	PF-00299804	5.4442
SIDM00217	COREAD\|large_intestine	p.G1069V (No)	GDSC	AST-1306	4.4781
SIDM00217	COREAD\|large_intestine	p.V667A (No)	GDSC	CI-1033	8.0923
SIDM00217	COREAD\|large_intestine	p.V667A (No)	GDSC	PF-00299804	5.4442
SIDM00217	COREAD\|large_intestine	p.V667A (No)	GDSC	AST-1306	4.4781
SIDM00217	COREAD\|large_intestine	p.N403S (No)	GDSC	CI-1033	8.0923
SIDM00217	COREAD\|large_intestine	p.N403S (No)	GDSC	PF-00299804	5.4442
SIDM00217	COREAD\|large_intestine	p.N403S (No)	GDSC	AST-1306	4.4781
SIDM00217	COREAD\|large_intestine	p.G338D (No)	GDSC	CI-1033	8.0923
SIDM00217	COREAD\|large_intestine	p.G338D (No)	GDSC	PF-00299804	5.4442
SIDM00217	COREAD\|large_intestine	p.G338D (No)	GDSC	AST-1306	4.4781
SIDM00217	COREAD\|large_intestine	p.G223E (No)	GDSC	CI-1033	8.0923
SIDM00217	COREAD\|large_intestine	p.G223E (No)	GDSC	PF-00299804	5.4442
SIDM00217	COREAD\|large_intestine	p.G223E (No)	GDSC	AST-1306	4.4781
SIDM00140	SKCM\|melanoma	p.G730E (No)	GDSC	CI-1033	4.6509
SIDM00140	SKCM\|melanoma	p.G730E (No)	GDSC	PF-00299804	3.5824
SIDM00140	SKCM\|melanoma	p.G730E (No)	GDSC	AST-1306	3.4539
SIDM00140	SKCM\|melanoma	p.G730R (No)	GDSC	CI-1033	4.6509
SIDM00140	SKCM\|melanoma	p.G730R (No)	GDSC	PF-00299804	3.5824
SIDM00140	SKCM\|melanoma	p.G730R (No)	GDSC	AST-1306	3.4539
SIDM00140	SKCM\|melanoma	p.M313I (No)	GDSC	CI-1033	4.6509
SIDM00140	SKCM\|melanoma	p.M313I (No)	GDSC	PF-00299804	3.5824
SIDM00140	SKCM\|melanoma	p.M313I (No)	GDSC	AST-1306	3.4539
SIDM00323	DLBC\|B_cell_lymphoma	p.P1249S (No)	GDSC	CI-1033	46.2567
SIDM00323	DLBC\|B_cell_lymphoma	p.P1249S (No)	GDSC	PF-00299804	9.5139
SIDM00323	DLBC\|B_cell_lymphoma	p.P1249S (No)	GDSC	AST-1306	6.1981
SIDM00243	UNCLASSIFIED\|testis	p.P1114L (No)	GDSC	CI-1033	2.9011
SIDM00243	UNCLASSIFIED\|testis	p.P1114L (No)	GDSC	PF-00299804	2.3614
SIDM00243	UNCLASSIFIED\|testis	p.P1114L (No)	GDSC	AST-1306	2.6068
SIDM00082	SKCM\|melanoma	p.R50C (No)	GDSC	CI-1033	1.6738
SIDM00082	SKCM\|melanoma	p.R50C (No)	GDSC	PF-00299804	11.8734
SIDM00082	SKCM\|melanoma	p.R50C (No)	GDSC	AST-1306	1.529
SIDM00889	CESC\|cervix	p.L1227M (No)	GDSC	CI-1033	0.9449
SIDM00889	CESC\|cervix	p.L1227M (No)	GDSC	PF-00299804	1.5392
SIDM00889	CESC\|cervix	p.L1227M (No)	GDSC	AST-1306	0.9173
SIDM00889	CESC\|cervix	p.I1226T (No)	GDSC	CI-1033	0.9449
SIDM00889	CESC\|cervix	p.I1226T (No)	GDSC	PF-00299804	1.5392
SIDM00889	CESC\|cervix	p.I1226T (No)	GDSC	AST-1306	0.9173
SIDM00839	COREAD\|large_intestine	p.R782Q (No)	GDSC	CI-1033	2.3204
SIDM00839	COREAD\|large_intestine	p.R782Q (No)	GDSC	PF-00299804	2.0335
SIDM00839	COREAD\|large_intestine	p.R782Q (No)	GDSC	AST-1306	4.1598
SIDM00216	COREAD\|large_intestine	p.R1250W (No)	GDSC	CI-1033	2.15
SIDM00216	COREAD\|large_intestine	p.R1250W (No)	GDSC	PF-00299804	1.4193
SIDM00216	COREAD\|large_intestine	p.R1250W (No)	GDSC	AST-1306	2.2393
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.P1299L (No)	GDSC	CI-1033	2.1216
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.P1299L (No)	GDSC	PF-00299804	2.2222
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.P1299L (No)	GDSC	AST-1306	2.318
SIDM00396	LAML\|acute_myeloid_leukaemia	p.V391I (No)	GDSC	CI-1033	0.7093
SIDM00396	LAML\|acute_myeloid_leukaemia	p.V391I (No)	GDSC	PF-00299804	1.3321
SIDM00396	LAML\|acute_myeloid_leukaemia	p.V391I (No)	GDSC	AST-1306	1.0731
SIDM01096	COREAD\|large_intestine	p.G758C (No)	GDSC	CI-1033	5.474
SIDM01096	COREAD\|large_intestine	p.G758C (No)	GDSC	PF-00299804	4.9215
SIDM01096	COREAD\|large_intestine	p.G758C (No)	GDSC	AST-1306	6.4973
SIDM01096	COREAD\|large_intestine	p.L567F (No)	GDSC	CI-1033	5.474
SIDM01096	COREAD\|large_intestine	p.L567F (No)	GDSC	PF-00299804	4.9215
SIDM01096	COREAD\|large_intestine	p.L567F (No)	GDSC	AST-1306	6.4973
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A1083S (No)	GDSC	CI-1033	9.1671
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A1083S (No)	GDSC	PF-00299804	3.2101
SIDM00344	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A1083S (No)	GDSC	AST-1306	2.114
SIDM00596	UCEC\|endometrium	p.L770P (No)	GDSC	CI-1033	8.9198
SIDM00596	UCEC\|endometrium	p.L770P (No)	GDSC	PF-00299804	17.4219
SIDM00596	UCEC\|endometrium	p.L770P (No)	GDSC	AST-1306	13.2253
SIDM00596	UCEC\|endometrium	p.T639M (No)	GDSC	CI-1033	8.9198
SIDM00596	UCEC\|endometrium	p.T639M (No)	GDSC	PF-00299804	17.4219
SIDM00596	UCEC\|endometrium	p.T639M (No)	GDSC	AST-1306	13.2253
SIDM00660	COREAD\|large_intestine	p.M882I (No)	GDSC	CI-1033	35.7038
SIDM00660	COREAD\|large_intestine	p.M882I (No)	GDSC	PF-00299804	7.2388
SIDM00660	COREAD\|large_intestine	p.M882I (No)	GDSC	AST-1306	12.0816
SIDM00660	COREAD\|large_intestine	p.R837G (No)	GDSC	CI-1033	35.7038
SIDM00660	COREAD\|large_intestine	p.R837G (No)	GDSC	PF-00299804	7.2388
SIDM00660	COREAD\|large_intestine	p.R837G (No)	GDSC	AST-1306	12.0816
SIDM00928	BRCA\|breast	p.M1017T (No)	GDSC	CI-1033	4.4545
SIDM00928	BRCA\|breast	p.M1017T (No)	GDSC	PF-00299804	3.6922
SIDM00928	BRCA\|breast	p.M1017T (No)	GDSC	AST-1306	4.0123
SIDM00094	KIRC\|kidney	p.T108fs*14 (No)	GDSC	CI-1033	24.105
SIDM00094	KIRC\|kidney	p.T108fs*14 (No)	GDSC	PF-00299804	8.29
SIDM00094	KIRC\|kidney	p.T108fs*14 (No)	GDSC	AST-1306	4.0648
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.L1247M (No)	GDSC	CI-1033	17.5583
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.L1247M (No)	GDSC	PF-00299804	10.841
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.L1247M (No)	GDSC	AST-1306	8.4474
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.S1246R (No)	GDSC	CI-1033	17.5583
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.S1246R (No)	GDSC	PF-00299804	10.841
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.S1246R (No)	GDSC	AST-1306	8.4474
SIDM00379	GBM\|glioma	p.L538F (No)	GDSC	CI-1033	21.0255
SIDM00379	GBM\|glioma	p.L538F (No)	GDSC	PF-00299804	7.2815
SIDM00379	GBM\|glioma	p.L538F (No)	GDSC	AST-1306	6.6768
SIDM00047	LUAD\|lung_NSCLC_adenocarcinoma	p.V1203L (No)	GDSC	CI-1033	13.1189
SIDM00047	LUAD\|lung_NSCLC_adenocarcinoma	p.V1203L (No)	GDSC	PF-00299804	10.0964
SIDM00047	LUAD\|lung_NSCLC_adenocarcinoma	p.V1203L (No)	GDSC	AST-1306	6.4315
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.M951L (No)	GDSC	CI-1033	287.8976
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.M951L (No)	GDSC	PF-00299804	36.7024
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.M951L (No)	GDSC	AST-1306	106.2904
SIDM00739	LUAD\|lung_NSCLC_adenocarcinoma	p.L1207M (No)	GDSC	CI-1033	13.8474
SIDM00739	LUAD\|lung_NSCLC_adenocarcinoma	p.L1207M (No)	GDSC	PF-00299804	9.5661
SIDM00739	LUAD\|lung_NSCLC_adenocarcinoma	p.L1207M (No)	GDSC	AST-1306	6.8615
SIDM00324	NB\|neuroblastoma	p.Y222* (No)	GDSC	CI-1033	17.1343
SIDM00324	NB\|neuroblastoma	p.Y222* (No)	GDSC	PF-00299804	7.6388
SIDM00324	NB\|neuroblastoma	p.Y222* (No)	GDSC	AST-1306	76.4825
SIDM00150	COREAD\|large_intestine	p.S418fs*2 (No)	GDSC	CI-1033	51.0403
SIDM00150	COREAD\|large_intestine	p.S418fs*2 (No)	GDSC	PF-00299804	15.2578
SIDM00150	COREAD\|large_intestine	p.S418fs*2 (No)	GDSC	AST-1306	23.595
SIDM00413	DLBC\|B_cell_lymphoma	p.V949I (No)	GDSC	CI-1033	45.3419
SIDM00413	DLBC\|B_cell_lymphoma	p.V949I (No)	GDSC	PF-00299804	23.2993
SIDM00413	DLBC\|B_cell_lymphoma	p.V949I (No)	GDSC	AST-1306	176.9086
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.G879* (No)	GDSC	CI-1033	8.2936
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.G879* (No)	GDSC	PF-00299804	4.2259
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.G879* (No)	GDSC	AST-1306	6.282
SIDM00789	COREAD\|large_intestine	p.L369I (No)	GDSC	CI-1033	193.7807
SIDM00789	COREAD\|large_intestine	p.L369I (No)	GDSC	PF-00299804	7.9634
SIDM00789	COREAD\|large_intestine	p.L369I (No)	GDSC	AST-1306	25.9277
SIDM00534	COREAD\|large_intestine	p.R992H (No)	GDSC	CI-1033	1.5327
SIDM00534	COREAD\|large_intestine	p.R992H (No)	GDSC	PF-00299804	1.7431
SIDM00534	COREAD\|large_intestine	p.R992H (No)	GDSC	AST-1306	1.4418
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E810K (No)	GDSC	CI-1033	4.0887
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E810K (No)	GDSC	PF-00299804	21.8673
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E810K (No)	GDSC	AST-1306	19.1221
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E452K (No)	GDSC	CI-1033	4.0887
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E452K (No)	GDSC	PF-00299804	21.8673
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E452K (No)	GDSC	AST-1306	19.1221
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.G31E (No)	GDSC	CI-1033	4.0887
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.G31E (No)	GDSC	PF-00299804	21.8673
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.G31E (No)	GDSC	AST-1306	19.1221
SIDM00487	COREAD\|large_intestine	p.L780P (No)	GDSC	CI-1033	0.1143
SIDM00487	COREAD\|large_intestine	p.L780P (No)	GDSC	PF-00299804	0.0699
SIDM00487	COREAD\|large_intestine	p.L780P (No)	GDSC	AST-1306	0.3311
SIDM00735	SCLC\|lung_small_cell_carcinoma	p.E1100D (No)	GDSC	CI-1033	19.3737
SIDM00735	SCLC\|lung_small_cell_carcinoma	p.E1100D (No)	GDSC	PF-00299804	10.4193
SIDM00735	SCLC\|lung_small_cell_carcinoma	p.E1100D (No)	GDSC	AST-1306	5.2164
SIDM00545	SKCM\|melanoma	p.M766I (No)	GDSC	CI-1033	23.8639
SIDM00545	SKCM\|melanoma	p.M766I (No)	GDSC	PF-00299804	24.0428
SIDM00545	SKCM\|melanoma	p.M766I (No)	GDSC	AST-1306	22.8082
SIDM00545	SKCM\|melanoma	p.S449F (No)	GDSC	CI-1033	23.8639
SIDM00545	SKCM\|melanoma	p.S449F (No)	GDSC	PF-00299804	24.0428
SIDM00545	SKCM\|melanoma	p.S449F (No)	GDSC	AST-1306	22.8082
SIDM00994	ALL\|T_cell_leukemia	p.A17V (No)	GDSC	CI-1033	1.2152
SIDM00994	ALL\|T_cell_leukemia	p.A17V (No)	GDSC	PF-00299804	2.3276
SIDM00994	ALL\|T_cell_leukemia	p.A17V (No)	GDSC	AST-1306	1.9704
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.Y1035H (No)	GDSC	CI-1033	3.2855
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.Y1035H (No)	GDSC	PF-00299804	4.9834
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.Y1035H (No)	GDSC	AST-1306	2.3638
SIDM00290	STAD\|stomach	p.M775I (No)	GDSC	CI-1033	7.3798
SIDM00290	STAD\|stomach	p.M775I (No)	GDSC	PF-00299804	16.2748
SIDM00290	STAD\|stomach	p.M775I (No)	GDSC	AST-1306	11.234
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.E316D (No)	GDSC	CI-1033	4.7495
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.E316D (No)	GDSC	PF-00299804	4.4903
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.E316D (No)	GDSC	AST-1306	5.4567
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.A4V (No)	GDSC	CI-1033	4.9793
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.A4V (No)	GDSC	PF-00299804	3.0583
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.A4V (No)	GDSC	AST-1306	4.9432
SIDM01233	COREAD\|large_intestine	p.T1110P (No)	GDSC	CI-1033	9.915
SIDM01233	COREAD\|large_intestine	p.T1110P (No)	GDSC	PF-00299804	9.1385
SIDM01233	COREAD\|large_intestine	p.T1110P (No)	GDSC	AST-1306	3.873
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.P619Q (No)	GDSC	CI-1033	0.679
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.P619Q (No)	GDSC	PF-00299804	0.5715
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.P619Q (No)	GDSC	AST-1306	0.8778
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.N1193D (No)	GDSC	CI-1033	57.6088
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.N1193D (No)	GDSC	PF-00299804	6.7384
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.N1193D (No)	GDSC	AST-1306	6.1738
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.C467R (No)	GDSC	CI-1033	57.6088
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.C467R (No)	GDSC	PF-00299804	6.7384
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.C467R (No)	GDSC	AST-1306	6.1738
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G816A (No)	GDSC	CI-1033	51.2544
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G816A (No)	GDSC	PF-00299804	29.8756
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G816A (No)	GDSC	AST-1306	11.7866
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G936R (No)	GDSC	CI-1033	189.7676
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G936R (No)	GDSC	PF-00299804	85.3776
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G936R (No)	GDSC	AST-1306	15.4504
SIDM00980	STAD\|stomach	p.D41fs*26 (No)	GDSC	CI-1033	8.2213
SIDM00980	STAD\|stomach	p.D41fs*26 (No)	GDSC	PF-00299804	12.8214
SIDM00980	STAD\|stomach	p.D41fs*26 (No)	GDSC	AST-1306	7.0898
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.M831I (No)	GDSC	CI-1033	7.1168
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.M831I (No)	GDSC	PF-00299804	6.3497
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.M831I (No)	GDSC	AST-1306	3.5929
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.Q826H (No)	GDSC	CI-1033	7.1168
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.Q826H (No)	GDSC	PF-00299804	6.3497
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.Q826H (No)	GDSC	AST-1306	3.5929
SIDM01060	SKCM\|melanoma	p.W171* (No)	GDSC	CI-1033	2.5374
SIDM01060	SKCM\|melanoma	p.W171* (No)	GDSC	PF-00299804	0.3855
SIDM01060	SKCM\|melanoma	p.W171* (No)	GDSC	AST-1306	0.3323
SIDM00419	UNCLASSIFIED\|ewings_sarcoma	p.A1236V (No)	GDSC	CI-1033	39.6122
SIDM00419	UNCLASSIFIED\|ewings_sarcoma	p.A1236V (No)	GDSC	PF-00299804	13.0985
SIDM00419	UNCLASSIFIED\|ewings_sarcoma	p.A1236V (No)	GDSC	AST-1306	10.6559
SIDM00539	ESCA\|oesophagus	p.M772L (No)	GDSC	CI-1033	0.1344
SIDM00539	ESCA\|oesophagus	p.M772L (No)	GDSC	PF-00299804	0.1055
SIDM00539	ESCA\|oesophagus	p.M772L (No)	GDSC	AST-1306	0.1053
SIDM00942	HNSC\|head_and_neck	p.N465K (No)	GDSC	CI-1033	10.9899
SIDM00942	HNSC\|head_and_neck	p.N465K (No)	GDSC	PF-00299804	14.6331
SIDM00942	HNSC\|head_and_neck	p.N465K (No)	GDSC	AST-1306	1.9208
SIDM00581	GBM\|glioma	p.T394S (No)	GDSC	CI-1033	7.1841
SIDM00581	GBM\|glioma	p.T394S (No)	GDSC	PF-00299804	9.4837
SIDM00581	GBM\|glioma	p.T394S (No)	GDSC	AST-1306	3.9102
SIDM01259	ALL\|lymphoblastic_leukemia	p.P1297L (No)	GDSC	CI-1033	26.5943
SIDM01259	ALL\|lymphoblastic_leukemia	p.P1297L (No)	GDSC	PF-00299804	7.2571
SIDM01259	ALL\|lymphoblastic_leukemia	p.P1297L (No)	GDSC	AST-1306	5.7931
SIDM00277	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.R524H (No)	GDSC	CI-1033	0.7557
SIDM00277	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.R524H (No)	GDSC	PF-00299804	4.3875
SIDM00277	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.R524H (No)	GDSC	AST-1306	5.0071
SIDM00148	BRCA\|breast	p.Y1242C (No)	GDSC	CI-1033	7.6005
SIDM00148	BRCA\|breast	p.Y1242C (No)	GDSC	PF-00299804	7.1883
SIDM00148	BRCA\|breast	p.Y1242C (No)	GDSC	AST-1306	6.9505
SIDM01027	ESCA\|oesophagus	p.Q93P (No)	GDSC	CI-1033	0.2481
SIDM01027	ESCA\|oesophagus	p.Q93P (No)	GDSC	PF-00299804	0.5468
SIDM01027	ESCA\|oesophagus	p.Q93P (No)	GDSC	AST-1306	0.4875
SIDM01146	STAD\|stomach	p.G511C (No)	GDSC	CI-1033	2.2418
SIDM01146	STAD\|stomach	p.G511C (No)	GDSC	PF-00299804	1.7179
SIDM01146	STAD\|stomach	p.G511C (No)	GDSC	AST-1306	0.9416
SIDM00837	COREAD\|large_intestine	p.P1196S (No)	GDSC	CI-1033	37.7483
SIDM00837	COREAD\|large_intestine	p.P1196S (No)	GDSC	PF-00299804	47.4842
SIDM00837	COREAD\|large_intestine	p.P1196S (No)	GDSC	AST-1306	9.4265
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.D1257E (No)	GDSC	CI-1033	36.8096
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.D1257E (No)	GDSC	PF-00299804	18.9073
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.D1257E (No)	GDSC	AST-1306	19.9553
SIDM00416	DLBC\|B_cell_lymphoma	p.T194A (No)	GDSC	CI-1033	3.7518
SIDM00416	DLBC\|B_cell_lymphoma	p.T194A (No)	GDSC	PF-00299804	2.5396
SIDM00416	DLBC\|B_cell_lymphoma	p.T194A (No)	GDSC	AST-1306	7.9178
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.E1100V (No)	GDSC	CI-1033	2.9775
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.E1100V (No)	GDSC	PF-00299804	2.9577
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.E1100V (No)	GDSC	AST-1306	3.9355
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.P309S (No)	GDSC	CI-1033	12.2259
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.P309S (No)	GDSC	PF-00299804	10.5608
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.P309S (No)	GDSC	AST-1306	4.613
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.G107V (No)	GDSC	CI-1033	12.2259
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.G107V (No)	GDSC	PF-00299804	10.5608
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.G107V (No)	GDSC	AST-1306	4.613
SIDM00693	BLCA\|bladder	p.R1045G (Yes)	GDSC	CI-1033	30.452
SIDM00693	BLCA\|bladder	p.R1045G (Yes)	GDSC	PF-00299804	16.2561
SIDM00693	BLCA\|bladder	p.R1045G (Yes)	GDSC	AST-1306	12.8772
SIDM00284	SKCM\|melanoma	p.G127E (No)	GDSC	CI-1033	8.4237
SIDM00284	SKCM\|melanoma	p.G127E (No)	GDSC	PF-00299804	22.8686
SIDM00284	SKCM\|melanoma	p.G127E (No)	GDSC	AST-1306	16.8593
SIDM00193	COREAD\|large_intestine	p.R95C (No)	GDSC	CI-1033	6.7985
SIDM00193	COREAD\|large_intestine	p.R95C (No)	GDSC	PF-00299804	9.5939
SIDM00193	COREAD\|large_intestine	p.R95C (No)	GDSC	AST-1306	3.7294
SIDM00118	COREAD\|large_intestine	p.K1002N (No)	GDSC	CI-1033	12.879
SIDM00118	COREAD\|large_intestine	p.K1002N (No)	GDSC	PF-00299804	19.2692
SIDM00118	COREAD\|large_intestine	p.K1002N (No)	GDSC	AST-1306	27.6776
SIDM00118	COREAD\|large_intestine	p.P594Q (No)	GDSC	CI-1033	12.879
SIDM00118	COREAD\|large_intestine	p.P594Q (No)	GDSC	PF-00299804	19.2692
SIDM00118	COREAD\|large_intestine	p.P594Q (No)	GDSC	AST-1306	27.6776
SIDM00118	COREAD\|large_intestine	p.I161M (No)	GDSC	CI-1033	12.879
SIDM00118	COREAD\|large_intestine	p.I161M (No)	GDSC	PF-00299804	19.2692
SIDM00118	COREAD\|large_intestine	p.I161M (No)	GDSC	AST-1306	27.6776
SIDM01248	THCA\|thyroid	p.G1049E (Yes)	GDSC	CI-1033	8.2727
SIDM01248	THCA\|thyroid	p.G1049E (Yes)	GDSC	PF-00299804	7.2249
SIDM01248	THCA\|thyroid	p.G1049E (Yes)	GDSC	AST-1306	7.1822

All proteins holding degron of PPAY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14497	AT-rich interactive domain-containing protein 1A	ITCH	145:148	PPAY	ITCH,NEDD4	0.9015	More...
O14559	Rho GTPase-activating protein 33	ITCH	1239:1242	PPAY	ITCH,NEDD4	0.9826	More...
O14640	Segment polarity protein dishevelled homolog DVL-1	ITCH	550:553	PPAY	ITCH,NEDD4	0.9898	More...
O14828	Secretory carrier-associated membrane protein 3	ITCH	50:53	PPAY	ITCH,NEDD4	0.9489	More...
O43561	Linker for activation of T-cells family member 1	ITCH	61:64	PPAY	ITCH,NEDD4	0.9978	More...
O75121	Microfibrillar-associated protein 3-like	ITCH	384:387	PPAY	ITCH,NEDD4	0.9598	More...
O75204	Transmembrane protein 127	ITCH	233:236	PPAY	ITCH,NEDD4	0.9861	More...
O75909	Cyclin-K	ITCH	462:465	PPAY	ITCH,NEDD4	0.5914	More...
O75952	Calcium-binding tyrosine phosphorylation-regulated protein	ITCH	270:273	PPAY	ITCH,NEDD4	0.9464	More...
O95415	Brain protein I3	ITCH	11:14	PPAY	ITCH,NEDD4	0.9941	More...
P18146	Early growth response protein 1	ITCH	237:240	PPAY	ITCH,NEDD4	0.9972	More...
P37088	Amiloride-sensitive sodium channel subunit alpha	ITCH	641:644	PPAY	ITCH,NEDD4	0.9695	More...
P43146	Netrin receptor DCC	ITCH	550:553	PPAY	ITCH,NEDD4	0.8629	More...
P78314	SH3 domain-binding protein 2	ITCH	201:204	PPAY	ITCH,NEDD4	0.958	More...
Q01892	Transcription factor Spi-B	ITCH	117:120	PPAY	ITCH,NEDD4	0.8619	More...
Q07912	Activated CDC42 kinase 1	ITCH	632:635	PPAY	ITCH,NEDD4	0.9991	More...
Q12809	Potassium voltage-gated channel subfamily H member 2	ITCH	1075:1078	PPAY	ITCH,NEDD4	0.9406	More...
Q14896	Myosin-binding protein C, cardiac-type	ITCH	794:797	PPAY	ITCH,NEDD4	0.9759	More...
Q15038	DAZ-associated protein 2	ITCH	39:42	PPAY	ITCH,NEDD4	0.9779	More...
Q15303	Receptor tyrosine-protein kinase erbB-4	ITCH	1053:1056	PPAY	ITCH,NEDD4	0.9956	More...
Q15468	SCL-interrupting locus protein	ITCH	508:511	PPAY	ITCH,NEDD4	0.9814	More...
Q15654	Thyroid receptor-interacting protein 6	ITCH	128:131	PPAY	ITCH,NEDD4	0.9801	More...
Q15797	Mothers against decapentaplegic homolog 1	ITCH	224:227	PPAY	ITCH,NEDD4	0.9965	More...
Q16655	Melanoma antigen recognized by T-cells 1	ITCH	101:104	PPAY	ITCH,NEDD4	0.9993	More...
Q5ST30	Valine--tRNA ligase, mitochondrial	ITCH	101:104	PPAY	ITCH,NEDD4	0.7036	More...
Q5T5C0	Syntaxin-binding protein 5	ITCH	872:875	PPAY	ITCH,NEDD4	0.9594	More...
Q5VX71	Sushi domain-containing protein 4	ITCH	411:414	PPAY	ITCH,NEDD4	0.9882	More...
Q86YV5	Inactive tyrosine-protein kinase PRAG1	ITCH	156:159	PPAY	ITCH,NEDD4	0.9989	More...
Q8N0X7	Spartin	ITCH	171:174	PPAY	ITCH,NEDD4	0.9972	More...
Q8N114	Protein shisa-5	ITCH	206:209	PPAY	ITCH,NEDD4	0.9175	More...
Q8N144	Gap junction delta-3 protein	ITCH	262:265	PPAY	ITCH,NEDD4	0.9919	More...
Q8N5H7	SH2 domain-containing protein 3C	ITCH	64:67	PPAY	ITCH,NEDD4	0.9787	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	ITCH	843:846	PPAY	ITCH,NEDD4	0.9548	More...
Q8NFW1	Collagen alpha-1	ITCH	1488:1491	PPAY	ITCH,NEDD4	0.9918	More...
Q92738	USP6 N-terminal-like protein	ITCH	809:812	PPAY	ITCH,NEDD4	0.9809	More...
Q96AW1	Vesicular, overexpressed in cancer, prosurvival protein 1	ITCH	154:157	PPAY	ITCH,NEDD4	0.97	More...
Q96EP0	E3 ubiquitin-protein ligase RNF31	ITCH	1046:1049	PPAY	ITCH,NEDD4	0.6799	More...
Q96JM7	Lethal	ITCH	84:87	PPAY	ITCH,NEDD4	0.8976	More...
Q99700	Ataxin-2	ITCH	1031:1034	PPAY	ITCH,NEDD4	0.991	More...
Q99717	Mothers against decapentaplegic homolog 5	ITCH	223:226	PPAY	ITCH,NEDD4	0.9821	More...
Q9BSR8	Protein YIPF4	ITCH	7:10	PPAY	ITCH,NEDD4	0.9115	More...
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	ITCH	781:784	PPAY	ITCH,NEDD4	0.9594	More...
Q9C0K7	STE20-related kinase adapter protein beta	ITCH	385:388	PPAY	ITCH,NEDD4	0.9824	More...
Q9H4L4	Sentrin-specific protease 3	ITCH	21:24	PPAY	ITCH,NEDD4	0.9368	More...
Q9NS40	Potassium voltage-gated channel subfamily H member 7	ITCH	1068:1071	PPAY	ITCH,NEDD4	0.8974	More...
Q9NVU7	Protein SDA1 homolog	ITCH	24:27	PPAY	ITCH,NEDD4	0.7681	More...
Q9UPU5	Ubiquitin carboxyl-terminal hydrolase 24	ITCH	98:101	PPAY	ITCH,NEDD4	0.9984	More...
Q9UPX0	Protein turtle homolog B	ITCH	925:928	PPAY	ITCH,NEDD4	0.9966	More...
Q9Y4P9	Sperm flagellar protein 1	ITCH	169:172	PPAY	ITCH,NEDD4	0.9985	More...
O15417	Trinucleotide repeat-containing gene 18 protein	ITCH	1018:1021	PPAY	ITCH,NEDD4	0.98	More...
P54792	Putative segment polarity protein dishevelled homolog DVL1P1	ITCH	525:528	PPAY	ITCH,NEDD4	0.9791	More...
Q8N0U2	Transmembrane protein 61	ITCH	147:150	PPAY	ITCH,NEDD4	0.7454	More...
Q9H0I9	Transketolase-like protein 2	ITCH	310:313	PPAY	ITCH,NEDD4	0.8808	More...
A6NMT0	Homeobox protein DBX1	ITCH	50:53	PPAY	ITCH,NEDD4	0.9932	More...
Q6UX72	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9	ITCH	65:68	PPAY	ITCH,NEDD4	0.8606	More...
Q6ZVC0	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1	ITCH	561:564	PPAY	ITCH,NEDD4	0.9991	More...
Q8IV13	Cyclin-J-like protein	ITCH	330:333	PPAY	ITCH,NEDD4	0.9938	More...
Q8N699	Myc target protein 1	ITCH	222:225	PPAY	ITCH,NEDD4	0.9901	More...
Q96G27	WW domain-binding protein 1	ITCH	124:127	PPAY	ITCH,NEDD4	0.9731	More...
Q9NWM3	CUE domain-containing protein 1	ITCH	133:136	PPAY	ITCH,NEDD4	0.993	More...
Q9ULL5	Proline-rich protein 12	ITCH	984:987	PPAY	ITCH,NEDD4	0.992	More...
A6NMB9	Fidgetin-like protein 2	ITCH	415:418	PPAY	ITCH,NEDD4	0.9107	More...
A8K5M9	Uncharacterized protein C15orf62, mitochondrial	ITCH	99:102	PPAY	ITCH,NEDD4	0.9174	More...
Q8N6L7	Transmembrane protein 252	ITCH	98:101	PPAY	ITCH,NEDD4	0.6068	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPAY

Degron related mutations and impact score

Drug responses associated with ERBB4 mutations

All proteins holding degron of PPAY