DegronMD - Q6UX72(B3GNT9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G166R	TCGA-2W-A8YY	CESC	TCGA	RRVFLLGVP	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.1389
p.G166R	DO223732	CESC	ICGC	RRVFLLGVP	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.1389
p.G166R	DO50346	ESAD	ICGC	RRVFLLGVP	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.1389
p.P75L	TCGA-33-4547	LUSC	TCGA	PPAY	ITCH	65:68	Mutation rewiring degron network	0.1389
p.P75L	DO234462	ESAD	ICGC	PPAY	ITCH	65:68	Mutation rewiring degron network	0.1389
p.P75L	DO26546	LUSC	ICGC	PPAY	ITCH	65:68	Mutation rewiring degron network	0.1389
p.P75L	DO229211	THCA	ICGC	PPAY	ITCH	65:68	Mutation rewiring degron network	0.1389
p.P75L	ACH-001380	Pancreatic Cancer	CCLE	PPAY	ITCH	65:68	Mutation rewiring degron network	0.1389
p.T77M	TCGA-CG-4306	STAD	TCGA	PPAY	ITCH	65:68	Mutation rewiring degron network	0.0833
p.T77M	DO38567	STAD	ICGC	PPAY	ITCH	65:68	Mutation rewiring degron network	0.0833
p.R151C	TCGA-D1-A103	UCEC	TCGA	RRVFLLGVP	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.719
p.R151C	DO42312	UCEC	ICGC	RRVFLLGVP	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.719
p.R151H	DO225120	BRCA	ICGC	RRVFLLGVP	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.7133
p.R151H	DO227903	BRCA	ICGC	RRVFLLGVP	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.7133
p.R151H	DO228069	EOPC	ICGC	RRVFLLGVP	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.7133
p.P75A	DO230311	COCA	ICGC	PPAY	ITCH	65:68	Mutation rewiring degron network	0.1389
p.G143S	DO229505	LAML	ICGC	RRVFLLGVP	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.1111
p.V158M	DO221128	MALY	ICGC	RRVFLLGVP	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.6097
p.A141V	SIDM00596	Endometrial Carcinoma	GDSC	RRVFLLGVP	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.0556
p.A141V	ACH-000941	Endometrial/Uterine Cancer	CCLE	RRVFLLGVP	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.0556
p.A141V	ACH-000954	Endometrial/Uterine Cancer	CCLE	RRVFLLGVP	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.0556
p.A141V	ACH-001517	Endometrial/Uterine Cancer	CCLE	RRVFLLGVP	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.0556
p.P59L	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PPAY	ITCH	65:68	Mutation rewiring degron network	0.1667
p.P59L	SIDM00655	Other Solid Cancers	GDSC	PPAY	ITCH	65:68	Mutation rewiring degron network	0.1667
p.P59L	SIDM01336	Glioblastoma	GDSC	PPAY	ITCH	65:68	Mutation rewiring degron network	0.1667
p.V150M	ACH-000954	Endometrial/Uterine Cancer	CCLE	RRVFLLGVP	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.3056

Kaplan plot for B3GNT9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

B3GNT9

UniProt ID: Q6UX72

Entrez ID: 84752

Protein name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 (BGnT-9) (Beta-1,3-Gn-T9) (Beta-1,3-N-acetylglucosaminyltransferase 9) (Beta3Gn-T9) (EC 2.4.1.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for B3GNT9 in