DegronMD

Uniprot ID: Q6UX72

Source protein: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9

Source gene: B3GNT9

Class: DEG_APCC_DBOX_1

Location: 151:159

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5109

ASA_SCORE: 17.7556

COIL: 0.1996

CONS_SCORE: 0.5893

DSS_SCORE: 0.2178

HELIX: 0.0037

FCONS_SCORE: 1.8896

RIG_SCORE: 0.8613

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G166R	TCGA-2W-A8YY	CESC	TCGA	RRVFLLGVP	DEG_APCC_DBOX_1	0.1389
p.G166R	DO223732	CESC	ICGC	RRVFLLGVP	DEG_APCC_DBOX_1	0.1389
p.G166R	DO50346	ESAD	ICGC	RRVFLLGVP	DEG_APCC_DBOX_1	0.1389
p.R151C	TCGA-D1-A103	UCEC	TCGA	RRVFLLGVP	DEG_APCC_DBOX_1	0.719
p.R151C	DO42312	UCEC	ICGC	RRVFLLGVP	DEG_APCC_DBOX_1	0.719
p.R151H	DO225120	BRCA	ICGC	RRVFLLGVP	DEG_APCC_DBOX_1	0.7133
p.R151H	DO227903	BRCA	ICGC	RRVFLLGVP	DEG_APCC_DBOX_1	0.7133
p.R151H	DO228069	EOPC	ICGC	RRVFLLGVP	DEG_APCC_DBOX_1	0.7133
p.G143S	DO229505	LAML	ICGC	RRVFLLGVP	DEG_APCC_DBOX_1	0.1111
p.V158M	DO221128	MALY	ICGC	RRVFLLGVP	DEG_APCC_DBOX_1	0.6097
p.A141V	SIDM00596	Endometrial Carcinoma	GDSC	RRVFLLGVP	DEG_APCC_DBOX_1	0.0556
p.A141V	ACH-000941	Endometrial/Uterine Cancer	CCLE	RRVFLLGVP	DEG_APCC_DBOX_1	0.0556
p.A141V	ACH-000954	Endometrial/Uterine Cancer	CCLE	RRVFLLGVP	DEG_APCC_DBOX_1	0.0556
p.A141V	ACH-001517	Endometrial/Uterine Cancer	CCLE	RRVFLLGVP	DEG_APCC_DBOX_1	0.0556
p.V150M	ACH-000954	Endometrial/Uterine Cancer	CCLE	RRVFLLGVP	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UX72	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9	DEG_APCC_DBOX_1	151:159	RRVFLLGVP	APC,CDC20,FZR1	0.5109	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons