DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPAY
Uniprot ID:
Q8N5H7
Source protein:
SH2 domain-containing protein 3C
Source gene:
SH2D3C
Class:
ITCH
Location:
64:67
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9787
ASA_SCORE:
69.775
COIL:
0.8305
CONS_SCORE:
0.2416
DSS_SCORE:
0.5707
HELIX:
0.11
FCONS_SCORE:
0.9512
RIG_SCORE:
0.6545
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R66H
DO219003
BLCA
ICGC
PPAY
ITCH
0.8244
p.R66H
DO10582
COAD
ICGC
PPAY
ITCH
0.8244
p.P65R
TCGA-51-4080
LUSC
TCGA
PPAY
ITCH
0.7512
p.P65R
DO26441
LUSC
ICGC
PPAY
ITCH
0.7512
p.Y67H
TCGA-85-A512
LUSC
TCGA
PPAY
ITCH
0.7229
p.Y67H
DO45425
LUSC
ICGC
PPAY
ITCH
0.7229
p.I67T
DO233171
GACA
ICGC
PPAY
ITCH
0.7078
p.Y74F
TCGA-06-1801
GBM
TCGA
PPAY
ITCH
0.5833
p.Y74F
DO11986
GBM
ICGC
PPAY
ITCH
0.5833
p.S62F
DO219723
CESC
ICGC
PPAY
ITCH
0.2778
p.R69H
DO45155
LIRI
ICGC
PPAY
ITCH
0.2778
p.G62E
SIDM00763
Non-Small Cell Lung Carcinoma
GDSC
PPAY
ITCH
0.2778
p.G62E
SIDM00140
Melanoma
GDSC
PPAY
ITCH
0.2778
p.G62E
COLO-792
skin
COSMIC
PPAY
ITCH
0.2778
p.G62E
NCI-H1915
lung
COSMIC
PPAY
ITCH
0.2778
p.Q61P
DO230326
COCA
ICGC
PPAY
ITCH
0.25
p.R60W
SIDM01716
Non-Cancerous
GDSC
PPAY
ITCH
0.2222
p.R60W
SIDM01263
T-Lymphoblastic Leukemia
GDSC
PPAY
ITCH
0.2222
p.R60W
SIDM00175
Melanoma
GDSC
PPAY
ITCH
0.2222
p.R60W
SIDM00807
Bladder Carcinoma
GDSC
PPAY
ITCH
0.2222
p.T59M
TCGA-HJ-7597
STAD
TCGA
PPAY
ITCH
0.1944
p.T59M
DO38195
STAD
ICGC
PPAY
ITCH
0.1944
p.T72A
DO49095
COAD
ICGC
PPAY
ITCH
0.1944
p.S59I
DO229208
THCA
ICGC
PPAY
ITCH
0.1944
p.E58K
DO8127
COAD
ICGC
PPAY
ITCH
0.1667
Showing 1 to 25 of 47 entries
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Drug responses associated with SH2D3C mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of PPAY
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q07912
Activated CDC42 kinase 1
ITCH
632:635
PPAY
ITCH,NEDD4
0.9991
More...
P37088
Amiloride-sensitive sodium channel subunit alpha
ITCH
641:644
PPAY
ITCH,NEDD4
0.9695
More...
O14497
AT-rich interactive domain-containing protein 1A
ITCH
145:148
PPAY
ITCH,NEDD4
0.9015
More...
Q8NFD5
AT-rich interactive domain-containing protein 1B
ITCH
843:846
PPAY
ITCH,NEDD4
0.9548
More...
Q99700
Ataxin-2
ITCH
1031:1034
PPAY
ITCH,NEDD4
0.991
More...
O95415
Brain protein I3
ITCH
11:14
PPAY
ITCH,NEDD4
0.9941
More...
O75952
Calcium-binding tyrosine phosphorylation-regulated protein
ITCH
270:273
PPAY
ITCH,NEDD4
0.9464
More...
Q8NFW1
Collagen alpha-1
ITCH
1488:1491
PPAY
ITCH,NEDD4
0.9918
More...
Q9NWM3
CUE domain-containing protein 1
ITCH
133:136
PPAY
ITCH,NEDD4
0.993
More...
Q8IV13
Cyclin-J-like protein
ITCH
330:333
PPAY
ITCH,NEDD4
0.9938
More...
O75909
Cyclin-K
ITCH
462:465
PPAY
ITCH,NEDD4
0.5914
More...
Q15038
DAZ-associated protein 2
ITCH
39:42
PPAY
ITCH,NEDD4
0.9779
More...
Q96EP0
E3 ubiquitin-protein ligase RNF31
ITCH
1046:1049
PPAY
ITCH,NEDD4
0.6799
More...
P18146
Early growth response protein 1
ITCH
237:240
PPAY
ITCH,NEDD4
0.9972
More...
A6NMB9
Fidgetin-like protein 2
ITCH
415:418
PPAY
ITCH,NEDD4
0.9107
More...
Q8N144
Gap junction delta-3 protein
ITCH
262:265
PPAY
ITCH,NEDD4
0.9919
More...
Q9BUJ2
Heterogeneous nuclear ribonucleoprotein U-like protein 1
ITCH
781:784
PPAY
ITCH,NEDD4
0.9594
More...
A6NMT0
Homeobox protein DBX1
ITCH
50:53
PPAY
ITCH,NEDD4
0.9932
More...
Q86YV5
Inactive tyrosine-protein kinase PRAG1
ITCH
156:159
PPAY
ITCH,NEDD4
0.9989
More...
Q96JM7
Lethal
ITCH
84:87
PPAY
ITCH,NEDD4
0.8976
More...
O43561
Linker for activation of T-cells family member 1
ITCH
61:64
PPAY
ITCH,NEDD4
0.9978
More...
Q16655
Melanoma antigen recognized by T-cells 1
ITCH
101:104
PPAY
ITCH,NEDD4
0.9993
More...
O75121
Microfibrillar-associated protein 3-like
ITCH
384:387
PPAY
ITCH,NEDD4
0.9598
More...
Q15797
Mothers against decapentaplegic homolog 1
ITCH
224:227
PPAY
ITCH,NEDD4
0.9965
More...
Q99717
Mothers against decapentaplegic homolog 5
ITCH
223:226
PPAY
ITCH,NEDD4
0.9821
More...
Showing 1 to 25 of 64 entries
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