DegronMD - Q9UPU5(USP24)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1294T	TCGA-13-1501	OV	TCGA	LCGTPEKS	DEG_SCF_FBW7_1	1286:1293	Mutation rewiring degron network	0.3056
p.S1294T	DO28168	OV	ICGC	LCGTPEKS	DEG_SCF_FBW7_1	1286:1293	Mutation rewiring degron network	0.3056
p.S2602L	TCGA-33-AASD	LUSC	TCGA	LRSDLDDVD	DEG_APCC_DBOX_1	2611:2619	Mutation blocking phosphorylation signal	0.5278
p.R1102W	TCGA-AP-A0LM	UCEC	TCGA	VRKLLLLIP	DEG_APCC_DBOX_1	1101:1109	Mutation altering degron motif	0.8634
p.R1102W	TCGA-E6-A1LX	UCEC	TCGA	VRKLLLLIP	DEG_APCC_DBOX_1	1101:1109	Mutation altering degron motif	0.8634
p.E2610K	TCGA-CN-A498	HNSC	TCGA	LRSDLDDVD	DEG_APCC_DBOX_1	2611:2619	Mutation rewiring degron network	0.3056
p.E2610K	DO52038	HNSC	ICGC	LRSDLDDVD	DEG_APCC_DBOX_1	2611:2619	Mutation rewiring degron network	0.3056
p.P2605L	TCGA-D3-A8GM	SKCM	TCGA	LRSDLDDVD	DEG_APCC_DBOX_1	2611:2619	Mutation rewiring degron network	0.1667
p.P2605L	DO50288	SKCM	ICGC	LRSDLDDVD	DEG_APCC_DBOX_1	2611:2619	Mutation rewiring degron network	0.1667
p.M2606T	TCGA-DX-A1L2	SARC	TCGA	LRSDLDDVD	DEG_APCC_DBOX_1	2611:2619	Mutation rewiring degron network	0.1944
p.M2606T	DO219951	SARC	ICGC	LRSDLDDVD	DEG_APCC_DBOX_1	2611:2619	Mutation rewiring degron network	0.1944
p.R1102L	TCGA-EE-A17Z	SKCM	TCGA	VRKLLLLIP	DEG_APCC_DBOX_1	1101:1109	Mutation altering degron motif	0.8428
p.P1072H	TCGA-FS-A1Z4	SKCM	TCGA	VFSSS	DEG_SPOP_SBC_1	1058:1062	Mutation rewiring degron network	0.0556
p.P1072H	DO37462	SKCM	ICGC	VFSSS	DEG_SPOP_SBC_1	1058:1062	Mutation rewiring degron network	0.0556
p.S1294F	TCGA-GN-A265	SKCM	TCGA	LCGTPEKS	DEG_SCF_FBW7_1	1286:1293	Mutation rewiring degron network	0.3056
p.A1048P	DO219052	BLCA	ICGC	VFSSS	DEG_SPOP_SBC_1	1058:1062	Mutation rewiring degron network	0.0556
p.G1284R	DO219915	DLBC	ICGC	LCGTPEKS	DEG_SCF_FBW7_1	1286:1293	Mutation rewiring degron network	0.2778
p.P111Q	DO234401	ESAD	ICGC	PPAY	ITCH	98:101	Mutation rewiring degron network	0.0556
p.I100V	DO233733	GACA	ICGC	PPAY	ITCH	98:101	Mutation altering degron motif	0.7076
p.D1061N	DO228881	LICA	ICGC	VFSSS	DEG_SPOP_SBC_1	1058:1062	Mutation altering degron motif	0.6932
p.L98I	DO228974	LICA	ICGC	PPAY	ITCH	98:101	Mutation altering degron motif	0.7174
p.Q1283K	DO229009	LICA	ICGC	LCGTPEKS	DEG_SCF_FBW7_1	1286:1293	Mutation rewiring degron network	0.25
p.S1052N	DO231724	LINC	ICGC	VFSSS	DEG_SPOP_SBC_1	1058:1062	Mutation rewiring degron network	0.1667
p.D1103Y	DO24780	LUAD	ICGC	VRKLLLLIP	DEG_APCC_DBOX_1	1101:1109	Mutation altering degron motif	0.7325
p.N94S	DO45469	LUSC	ICGC	PPAY	ITCH	98:101	Mutation rewiring degron network	0.2222
p.M68I	DO228411	MALY	ICGC	DSGGGPS	DEG_SCF_TRCP1_1	57:63	Mutation rewiring degron network	0.1944
p.P111S	DO222363	MELA	ICGC	PPAY	ITCH	98:101	Mutation rewiring degron network	0.0556
p.D2614G	DO51082	PRAD	ICGC	LRSDLDDVD	DEG_APCC_DBOX_1	2611:2619	Mutation altering degron motif	0.6087
p.T1049A	DO233424	RECA	ICGC	VFSSS	DEG_SPOP_SBC_1	1058:1062	Mutation rewiring degron network	0.0833
p.R2612K	DO229502	SKCA	ICGC	LRSDLDDVD	DEG_APCC_DBOX_1	2611:2619	Mutation altering degron motif	0.7237
p.D2616E	SIDM00545	Melanoma	GDSC	LRSDLDDVD	DEG_APCC_DBOX_1	2611:2619	Mutation altering degron motif	0.5647
p.D2616E	ACH-000987	Skin Cancer	CCLE	LRSDLDDVD	DEG_APCC_DBOX_1	2611:2619	Mutation altering degron motif	0.5647
p.D2616E	Mewo	skin	COSMIC	LRSDLDDVD	DEG_APCC_DBOX_1	2611:2619	Mutation altering degron motif	0.5647
p.R1303M	SIDM00732	Glioblastoma	GDSC	LCGTPEKS	DEG_SCF_FBW7_1	1286:1293	Mutation rewiring degron network	0.0556
p.R1303M	ACH-002225	Brain Cancer	CCLE	LCGTPEKS	DEG_SCF_FBW7_1	1286:1293	Mutation rewiring degron network	0.0556
p.R1303M	D-263MG	central nervous system	COSMIC	LCGTPEKS	DEG_SCF_FBW7_1	1286:1293	Mutation rewiring degron network	0.0556
p.S88R	ACH-000790	Lung Cancer	CCLE	PPAY	ITCH	98:101	Mutation blocking phosphorylation signal	0.5
p.P2620L	ACH-001367	Neuroblastoma	CCLE	LRSDLDDVD	DEG_APCC_DBOX_1	2611:2619	Mutation rewiring degron network	0.3056

Kaplan plot for USP24 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP24

UniProt ID: Q9UPU5

Entrez ID: 23358

Protein name: Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP24 in