DegronMD - Q9UPU5(USP24)

FUNCTION: Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron. {ECO:0000269|PubMed:23159851, ECO:0000269|PubMed:29695420}.

GO - Biological processes (BP): protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511]

GO - Molecular function (MF): cysteine-type endopeptidase activity [GO:0004197]; thiol-dependent deubiquitinase [GO:0004843]

GO - Cellular component (CC): cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1102W	TCGA-AP-A0LM	UCEC	TCGA	VRKLLLLIP	DEG_APCC_DBOX_1	1101:1109	Mutation altering degron motif	0.8634
p.R1102W	TCGA-E6-A1LX	UCEC	TCGA	VRKLLLLIP	DEG_APCC_DBOX_1	1101:1109	Mutation altering degron motif	0.8634
p.R1102L	TCGA-EE-A17Z	SKCM	TCGA	VRKLLLLIP	DEG_APCC_DBOX_1	1101:1109	Mutation altering degron motif	0.8428
p.D1103Y	DO24780	LUAD	ICGC	VRKLLLLIP	DEG_APCC_DBOX_1	1101:1109	Mutation altering degron motif	0.7325
p.R2612K	DO229502	SKCA	ICGC	LRSDLDDVD	DEG_APCC_DBOX_1	2611:2619	Mutation altering degron motif	0.7237
p.L98I	DO228974	LICA	ICGC	PPAY	ITCH	98:101	Mutation altering degron motif	0.7174
p.I100V	DO233733	GACA	ICGC	PPAY	ITCH	98:101	Mutation altering degron motif	0.7076
p.D1061N	DO228881	LICA	ICGC	VFSSS	DEG_SPOP_SBC_1	1058:1062	Mutation altering degron motif	0.6932
p.D2614G	DO51082	PRAD	ICGC	LRSDLDDVD	DEG_APCC_DBOX_1	2611:2619	Mutation altering degron motif	0.6087
p.D2616E	SIDM00545	Melanoma	GDSC	LRSDLDDVD	DEG_APCC_DBOX_1	2611:2619	Mutation altering degron motif	0.5647
p.D2616E	ACH-000987	Skin Cancer	CCLE	LRSDLDDVD	DEG_APCC_DBOX_1	2611:2619	Mutation altering degron motif	0.5647
p.D2616E	Mewo	skin	COSMIC	LRSDLDDVD	DEG_APCC_DBOX_1	2611:2619	Mutation altering degron motif	0.5647
p.S2602L	TCGA-33-AASD	LUSC	TCGA	LRSDLDDVD	DEG_APCC_DBOX_1	2611:2619	Mutation blocking phosphorylation signal	0.5278
p.S88R	ACH-000790	Lung Cancer	CCLE	PPAY	ITCH	98:101	Mutation blocking phosphorylation signal	0.5
p.S1294T	TCGA-13-1501	OV	TCGA	LCGTPEKS	DEG_SCF_FBW7_1	1286:1293	Mutation rewiring degron network	0.3056
p.S1294T	DO28168	OV	ICGC	LCGTPEKS	DEG_SCF_FBW7_1	1286:1293	Mutation rewiring degron network	0.3056
p.E2610K	TCGA-CN-A498	HNSC	TCGA	LRSDLDDVD	DEG_APCC_DBOX_1	2611:2619	Mutation rewiring degron network	0.3056
p.E2610K	DO52038	HNSC	ICGC	LRSDLDDVD	DEG_APCC_DBOX_1	2611:2619	Mutation rewiring degron network	0.3056
p.S1294F	TCGA-GN-A265	SKCM	TCGA	LCGTPEKS	DEG_SCF_FBW7_1	1286:1293	Mutation rewiring degron network	0.3056
p.P2620L	ACH-001367	Neuroblastoma	CCLE	LRSDLDDVD	DEG_APCC_DBOX_1	2611:2619	Mutation rewiring degron network	0.3056

Showing 1 to 20 of 38 entries

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP24

UniProt ID: Q9UPU5

Entrez ID: 23358

Protein name: Ubiquitin carboxyl-terminal hydrolase 24 (EC 3.4.19.12) (Deubiquitinating enzyme 24) (Ubiquitin thioesterase 24) (Ubiquitin-specific-processing protease 24)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP24 in