DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
DSGGGPS
Uniprot ID:
Q9UPU5
Source protein:
Ubiquitin carboxyl-terminal hydrolase 24
Source gene:
USP24
Class:
DEG_SCF_TRCP1_1
Location:
57:63
E3 ligase:
BTRC
DEGRON score:
0.998
ASA_SCORE:
61.3857
COIL:
0.947
CONS_SCORE:
0.2748
DSS_SCORE:
0.7559
HELIX:
0.0337
FCONS_SCORE:
0.9973
RIG_SCORE:
0.478
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.M68I
DO228411
MALY
ICGC
DSGGGPS
DEG_SCF_TRCP1_1
0.1944
Drug responses associated with USP24 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGGGPS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UPU5
Ubiquitin carboxyl-terminal hydrolase 24
DEG_SCF_TRCP1_1
57:63
DSGGGPS
BTRC
0.998
More...