DegronMD

Uniprot ID: Q9UPU5

Source protein: Ubiquitin carboxyl-terminal hydrolase 24

Source gene: USP24

Class: DEG_SCF_FBW7_1

Location: 1286:1293

E3 ligase: FBXW7

DEGRON score: 0.9991

ASA_SCORE: 72.7

COIL: 0.8056

CONS_SCORE: 0.2831

DSS_SCORE: 0.5414

HELIX: 0.1411

FCONS_SCORE: 1.0355

RIG_SCORE: 0.683

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1294T	TCGA-13-1501	OV	TCGA	LCGTPEKS	DEG_SCF_FBW7_1	0.3056
p.S1294T	DO28168	OV	ICGC	LCGTPEKS	DEG_SCF_FBW7_1	0.3056
p.S1294F	TCGA-GN-A265	SKCM	TCGA	LCGTPEKS	DEG_SCF_FBW7_1	0.3056
p.G1284R	DO219915	DLBC	ICGC	LCGTPEKS	DEG_SCF_FBW7_1	0.2778
p.Q1283K	DO229009	LICA	ICGC	LCGTPEKS	DEG_SCF_FBW7_1	0.25
p.R1303M	SIDM00732	Glioblastoma	GDSC	LCGTPEKS	DEG_SCF_FBW7_1	0.0556
p.R1303M	ACH-002225	Brain Cancer	CCLE	LCGTPEKS	DEG_SCF_FBW7_1	0.0556
p.R1303M	D-263MG	central_nervous_system	COSMIC	LCGTPEKS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPU5	Ubiquitin carboxyl-terminal hydrolase 24	DEG_SCF_FBW7_1	1286:1293	LCGTPEKS	FBXW7	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons