DegronMD

Uniprot ID: Q9UPU5

Source protein: Ubiquitin carboxyl-terminal hydrolase 24

Source gene: USP24

Class: DEG_APCC_DBOX_1

Location: 2611:2619

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9177

ASA_SCORE: 90.1333

COIL: 0.6348

CONS_SCORE: 0.3353

DSS_SCORE: 0.8814

HELIX: 0.3461

FCONS_SCORE: 1.011

RIG_SCORE: 0.7112

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2602L	TCGA-33-AASD	LUSC	TCGA	LRSDLDDVD	DEG_APCC_DBOX_1	0.5278
p.E2610K	TCGA-CN-A498	HNSC	TCGA	LRSDLDDVD	DEG_APCC_DBOX_1	0.3056
p.E2610K	DO52038	HNSC	ICGC	LRSDLDDVD	DEG_APCC_DBOX_1	0.3056
p.P2605L	TCGA-D3-A8GM	SKCM	TCGA	LRSDLDDVD	DEG_APCC_DBOX_1	0.1667
p.P2605L	DO50288	SKCM	ICGC	LRSDLDDVD	DEG_APCC_DBOX_1	0.1667
p.M2606T	TCGA-DX-A1L2	SARC	TCGA	LRSDLDDVD	DEG_APCC_DBOX_1	0.1944
p.M2606T	DO219951	SARC	ICGC	LRSDLDDVD	DEG_APCC_DBOX_1	0.1944
p.D2614G	DO51082	PRAD	ICGC	LRSDLDDVD	DEG_APCC_DBOX_1	0.6087
p.R2612K	DO229502	SKCA	ICGC	LRSDLDDVD	DEG_APCC_DBOX_1	0.7237
p.D2616E	SIDM00545	Melanoma	GDSC	LRSDLDDVD	DEG_APCC_DBOX_1	0.5647
p.D2616E	ACH-000987	Skin Cancer	CCLE	LRSDLDDVD	DEG_APCC_DBOX_1	0.5647
p.D2616E	Mewo	skin	COSMIC	LRSDLDDVD	DEG_APCC_DBOX_1	0.5647
p.P2620L	ACH-001367	Neuroblastoma	CCLE	LRSDLDDVD	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPU5	Ubiquitin carboxyl-terminal hydrolase 24	DEG_APCC_DBOX_1	2611:2619	LRSDLDDVD	APC,CDC20,FZR1	0.9177	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons