DegronMD

Uniprot ID: Q9UPU5

Source protein: Ubiquitin carboxyl-terminal hydrolase 24

Source gene: USP24

Class: DEG_APCC_DBOX_1

Location: 1101:1109

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.732

ASA_SCORE: 48.3111

COIL: 0.337

CONS_SCORE: 0.5777

DSS_SCORE: 0.0455

HELIX: 0.6567

FCONS_SCORE: 1.4247

RIG_SCORE: 0.9087

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1102W	TCGA-AP-A0LM	UCEC	TCGA	VRKLLLLIP	DEG_APCC_DBOX_1	0.8634
p.R1102W	TCGA-E6-A1LX	UCEC	TCGA	VRKLLLLIP	DEG_APCC_DBOX_1	0.8634
p.R1102L	TCGA-EE-A17Z	SKCM	TCGA	VRKLLLLIP	DEG_APCC_DBOX_1	0.8428
p.D1103Y	DO24780	LUAD	ICGC	VRKLLLLIP	DEG_APCC_DBOX_1	0.7325

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPU5	Ubiquitin carboxyl-terminal hydrolase 24	DEG_APCC_DBOX_1	1101:1109	VRKLLLLIP	APC,CDC20,FZR1	0.732	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons