DegronMD - Q96EP0(RNF31)

FUNCTION: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28481331, PubMed:28189684). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777, PubMed:28189684). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173, PubMed:28189684). LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846, PubMed:27458237). The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria (PubMed:28481331, PubMed:34012115). LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin (PubMed:28481331). Recruited to the surface of bacteria by RNF213, which initiates the bacterial ubiquitin coat (PubMed:34012115). The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation (PubMed:28481331, PubMed:34012115). Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (PubMed:23708998). RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa-B activation (PubMed:27777308). Binds polyubiquitin of different linkage types (PubMed:23708998). {ECO:0000269|PubMed:17006537, ECO:0000269|PubMed:19136968, ECO:0000269|PubMed:20005846, ECO:0000269|PubMed:21455173, ECO:0000269|PubMed:21455180, ECO:0000269|PubMed:21455181, ECO:0000269|PubMed:22863777, ECO:0000269|PubMed:23708998, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27777308, ECO:0000269|PubMed:28189684, ECO:0000269|PubMed:28481331, ECO:0000269|PubMed:34012115}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P633H	TCGA-55-6971	LUAD	TCGA	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation rewiring degron network	0.3056
p.P633H	TCGA-EE-A2MK	SKCM	TCGA	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation rewiring degron network	0.3056
p.R616H	TCGA-A5-A2K7	UCEC	TCGA	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation rewiring degron network	0.0556
p.R1037C	TCGA-CR-7401	HNSC	TCGA	PPAY	ITCH	1046:1049	Mutation rewiring degron network	0.0833
p.R1037C	TCGA-FI-A2D0	UCEC	TCGA	PPAY	ITCH	1046:1049	Mutation rewiring degron network	0.0833
p.R616C	TCGA-DX-A6BF	SARC	TCGA	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation rewiring degron network	0.0556
p.L617I	TCGA-G7-6797	KIRP	TCGA	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation rewiring degron network	0.0833
p.K633M	DO222404	BTCA	ICGC	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation rewiring degron network	0.3056
p.R283Q	DO10443	COAD	ICGC	PQSTS	DEG_SPOP_SBC_1	279:283	Mutation altering degron motif	0.7329
p.A628E	DO21978	LAML	ICGC	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation altering degron motif	0.7701
p.M280I	DO229029	LICA	ICGC	PQSTS	DEG_SPOP_SBC_1	279:283	Mutation altering degron motif	0.7618
p.A290S	DO229026	LICA	ICGC	PQSTS	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.1389
p.V277L	DO229009	LICA	ICGC	PQSTS	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.2778
p.W276C	DO45311	LUAD	ICGC	PQSTS	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.25
p.S272L	DO46657	PAAD	ICGC	PQSTS	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.1389
p.P289S	DO37819	SKCM	ICGC	PQSTS	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.1667
p.S285C	DO50301	SKCM	ICGC	PQSTS	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.2778
p.R619C	DO51276	SKCM	ICGC	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation rewiring degron network	0.1389
p.R619C	DO43041	UCEC	ICGC	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation rewiring degron network	0.1389
p.K632N	DO47911	STAD	ICGC	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation altering degron motif	0.6918
p.E636K	DO42352	UCEC	ICGC	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation rewiring degron network	0.2222
p.A628V	DO41871	UCEC	ICGC	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation altering degron motif	0.6936
p.A1048V	SIDM02015	Colorectal Carcinoma	GDSC	PPAY	ITCH	1046:1049	Mutation altering degron motif	0.5825
p.V1036L	SIDM00683	Prostate Carcinoma	GDSC	PPAY	ITCH	1046:1049	Mutation rewiring degron network	0.0556
p.V1036L	SIDM00200	Ewing's Sarcoma	GDSC	PPAY	ITCH	1046:1049	Mutation rewiring degron network	0.0556
p.V1036L	SIDM00690	Head and Neck Carcinoma	GDSC	PPAY	ITCH	1046:1049	Mutation rewiring degron network	0.0556
p.V1036L	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PPAY	ITCH	1046:1049	Mutation rewiring degron network	0.0556
p.G628D	SIDM00770	Small Cell Lung Carcinoma	GDSC	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation altering degron motif	0.7198
p.G628D	NCI-H1836	lung	COSMIC	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation altering degron motif	0.7198
p.E618D	SIDM00866	Breast Carcinoma	GDSC	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation rewiring degron network	0.1111
p.E618D	HCC1143	breast	COSMIC	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation rewiring degron network	0.1111
p.Q622L	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation rewiring degron network	0.2222
p.Q622L	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation rewiring degron network	0.2222
p.Q622L	SIDM00220	Ovarian Carcinoma	GDSC	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation rewiring degron network	0.2222
p.Q622L	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation rewiring degron network	0.2222
p.Q622R	SIDM00889	Cervical Carcinoma	GDSC	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation rewiring degron network	0.2222
p.Q622R	C-33-A	cervix	COSMIC	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation rewiring degron network	0.2222
p.R623C	SIDM01051	Ovarian Carcinoma	GDSC	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation rewiring degron network	0.25
p.R623C	EFO-27	ovary	COSMIC	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation rewiring degron network	0.25
p.R621H	SIDM00217	Colorectal Carcinoma	GDSC	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation rewiring degron network	0.1944
p.R621H	SNU-1040	large intestine	COSMIC	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation rewiring degron network	0.1944
p.S273I	EMC-BAC-1	lung	COSMIC	PQSTS	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.1667
p.I288V	SNU-81	large intestine	COSMIC	PQSTS	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.1944
p.P624T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DSGPEPT	DEG_SCF_TRCP1_1	626:632	Mutation rewiring degron network	0.2778
p.S286G	EN	endometrium	COSMIC	PQSTS	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.25

Kaplan plot for RNF31 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RNF31

UniProt ID: Q96EP0

Entrez ID: 55072

Protein name: E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RNF31 in