DegronMD

Uniprot ID: Q96EP0

Source protein: E3 ubiquitin-protein ligase RNF31

Source gene: RNF31

Class: DEG_SCF_TRCP1_1

Location: 626:632

E3 ligase: BTRC

DEGRON score: 0.5285

ASA_SCORE: 74.8857

COIL: 0.9381

CONS_SCORE: 0.4459

DSS_SCORE: 0.6037

HELIX: 0.0314

FCONS_SCORE: 0.8507

RIG_SCORE: 0.6115

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P633H	TCGA-55-6971	LUAD	TCGA	DSGPEPT	DEG_SCF_TRCP1_1	0.3056
p.P633H	TCGA-EE-A2MK	SKCM	TCGA	DSGPEPT	DEG_SCF_TRCP1_1	0.3056
p.R616H	TCGA-A5-A2K7	UCEC	TCGA	DSGPEPT	DEG_SCF_TRCP1_1	0.0556
p.R616C	TCGA-DX-A6BF	SARC	TCGA	DSGPEPT	DEG_SCF_TRCP1_1	0.0556
p.L617I	TCGA-G7-6797	KIRP	TCGA	DSGPEPT	DEG_SCF_TRCP1_1	0.0833
p.K633M	DO222404	BTCA	ICGC	DSGPEPT	DEG_SCF_TRCP1_1	0.3056
p.A628E	DO21978	LAML	ICGC	DSGPEPT	DEG_SCF_TRCP1_1	0.7701
p.R619C	DO51276	SKCM	ICGC	DSGPEPT	DEG_SCF_TRCP1_1	0.1389
p.R619C	DO43041	UCEC	ICGC	DSGPEPT	DEG_SCF_TRCP1_1	0.1389
p.K632N	DO47911	STAD	ICGC	DSGPEPT	DEG_SCF_TRCP1_1	0.6918
p.E636K	DO42352	UCEC	ICGC	DSGPEPT	DEG_SCF_TRCP1_1	0.2222
p.A628V	DO41871	UCEC	ICGC	DSGPEPT	DEG_SCF_TRCP1_1	0.6936
p.G628D	SIDM00770	Small Cell Lung Carcinoma	GDSC	DSGPEPT	DEG_SCF_TRCP1_1	0.7198
p.G628D	NCI-H1836	lung	COSMIC	DSGPEPT	DEG_SCF_TRCP1_1	0.7198
p.E618D	SIDM00866	Breast Carcinoma	GDSC	DSGPEPT	DEG_SCF_TRCP1_1	0.1111
p.E618D	HCC1143	breast	COSMIC	DSGPEPT	DEG_SCF_TRCP1_1	0.1111
p.Q622L	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	DSGPEPT	DEG_SCF_TRCP1_1	0.2222
p.Q622L	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGPEPT	DEG_SCF_TRCP1_1	0.2222
p.Q622L	SIDM00220	Ovarian Carcinoma	GDSC	DSGPEPT	DEG_SCF_TRCP1_1	0.2222
p.Q622L	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGPEPT	DEG_SCF_TRCP1_1	0.2222
p.Q622R	SIDM00889	Cervical Carcinoma	GDSC	DSGPEPT	DEG_SCF_TRCP1_1	0.2222
p.Q622R	C-33-A	cervix	COSMIC	DSGPEPT	DEG_SCF_TRCP1_1	0.2222
p.R623C	SIDM01051	Ovarian Carcinoma	GDSC	DSGPEPT	DEG_SCF_TRCP1_1	0.25
p.R623C	EFO-27	ovary	COSMIC	DSGPEPT	DEG_SCF_TRCP1_1	0.25
p.R621H	SIDM00217	Colorectal Carcinoma	GDSC	DSGPEPT	DEG_SCF_TRCP1_1	0.1944
p.R621H	SNU-1040	large_intestine	COSMIC	DSGPEPT	DEG_SCF_TRCP1_1	0.1944
p.P624T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	DSGPEPT	DEG_SCF_TRCP1_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGPEPT

Degron related mutations and impact score

Drug responses associated with RNF31 mutations

All proteins holding degron of DSGPEPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96EP0	E3 ubiquitin-protein ligase RNF31	DEG_SCF_TRCP1_1	626:632	DSGPEPT	BTRC	0.5285	More...