DegronMD

Uniprot ID: Q96EP0

Source protein: E3 ubiquitin-protein ligase RNF31

Source gene: RNF31

Class: DEG_SPOP_SBC_1

Location: 279:283

E3 ligase: SPOP

DEGRON score: 0.9473

ASA_SCORE: 81.08

COIL: 0.8884

CONS_SCORE: 0.516

DSS_SCORE: 0.5789

HELIX: 0.0856

FCONS_SCORE: 1.0242

RIG_SCORE: 0.6575

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R283Q	DO10443	COAD	ICGC	PQSTS	DEG_SPOP_SBC_1	0.7329
p.M280I	DO229029	LICA	ICGC	PQSTS	DEG_SPOP_SBC_1	0.7618
p.A290S	DO229026	LICA	ICGC	PQSTS	DEG_SPOP_SBC_1	0.1389
p.V277L	DO229009	LICA	ICGC	PQSTS	DEG_SPOP_SBC_1	0.2778
p.W276C	DO45311	LUAD	ICGC	PQSTS	DEG_SPOP_SBC_1	0.25
p.S272L	DO46657	PAAD	ICGC	PQSTS	DEG_SPOP_SBC_1	0.1389
p.P289S	DO37819	SKCM	ICGC	PQSTS	DEG_SPOP_SBC_1	0.1667
p.S285C	DO50301	SKCM	ICGC	PQSTS	DEG_SPOP_SBC_1	0.2778
p.S273I	EMC-BAC-1	lung	COSMIC	PQSTS	DEG_SPOP_SBC_1	0.1667
p.I288V	SNU-81	large_intestine	COSMIC	PQSTS	DEG_SPOP_SBC_1	0.1944
p.S286G	EN	endometrium	COSMIC	PQSTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	1147:1151	PQSTS	SPOP	0.9731	More...
P07202	Thyroid peroxidase	DEG_SPOP_SBC_1	245:249	PQSTS	SPOP	0.8902	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	1112:1116	PQSTS	SPOP	0.9975	More...
Q14114	Low-density lipoprotein receptor-related protein 8	DEG_SPOP_SBC_1	738:742	PQSTS	SPOP	0.7494	More...
Q92817	Envoplakin	DEG_SPOP_SBC_1	1806:1810	PQSTS	SPOP	0.681	More...
Q96EP0	E3 ubiquitin-protein ligase RNF31	DEG_SPOP_SBC_1	279:283	PQSTS	SPOP	0.9473	More...
Q9NU22	Midasin	DEG_SPOP_SBC_1	1546:1550	PQSTS	SPOP	0.568	More...
Q9P2H0	Centrosomal protein of 126 kDa	DEG_SPOP_SBC_1	804:808	PQSTS	SPOP	0.9041	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_SPOP_SBC_1	502:506	PQSTS	SPOP	0.9849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons