DegronMD

Uniprot ID: Q13428

Source protein: Treacle protein

Source gene: TCOF1

Class: DEG_SPOP_SBC_1

Location: 1112:1116

E3 ligase: SPOP

DEGRON score: 0.9975

ASA_SCORE: 96.6

COIL: 0.9428

CONS_SCORE: 0.4943

DSS_SCORE: 0.6368

HELIX: 0.0276

FCONS_SCORE: 1.3127

RIG_SCORE: 0.6362

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1121R	TCGA-24-1104	OV	TCGA	PQSTS	DEG_SPOP_SBC_1	0.1944
p.A1103D	TCGA-A5-A1OF	UCEC	TCGA	PQSTS	DEG_SPOP_SBC_1	0.0833
p.A1103D	DO42568	UCEC	ICGC	PQSTS	DEG_SPOP_SBC_1	0.0833
p.P1108S	TCGA-D9-A1JX	SKCM	TCGA	PQSTS	DEG_SPOP_SBC_1	0.2222
p.P1108S	DO37711	SKCM	ICGC	PQSTS	DEG_SPOP_SBC_1	0.2222
p.G1121W	TCGA-FS-A1Z0	SKCM	TCGA	PQSTS	DEG_SPOP_SBC_1	0.1944
p.A1119V	TCGA-GN-A26C	SKCM	TCGA	PQSTS	DEG_SPOP_SBC_1	0.25
p.D1110Y	DO229027	LICA	ICGC	PQSTS	DEG_SPOP_SBC_1	0.7222
p.S1104I	DO229026	LICA	ICGC	PQSTS	DEG_SPOP_SBC_1	0.1111
p.S1114I	DO229045	LICA	ICGC	PQSTS	DEG_SPOP_SBC_1	0.8453
p.Q1126H	DO43049	UCEC	ICGC	PQSTS	DEG_SPOP_SBC_1	0.0556
p.S1124F	MOG-G-CCM	central_nervous_system	COSMIC	PQSTS	DEG_SPOP_SBC_1	0.2222
p.S1125F	MOG-G-CCM	central_nervous_system	COSMIC	PQSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	1147:1151	PQSTS	SPOP	0.9731	More...
P07202	Thyroid peroxidase	DEG_SPOP_SBC_1	245:249	PQSTS	SPOP	0.8902	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	1112:1116	PQSTS	SPOP	0.9975	More...
Q14114	Low-density lipoprotein receptor-related protein 8	DEG_SPOP_SBC_1	738:742	PQSTS	SPOP	0.7494	More...
Q92817	Envoplakin	DEG_SPOP_SBC_1	1806:1810	PQSTS	SPOP	0.681	More...
Q96EP0	E3 ubiquitin-protein ligase RNF31	DEG_SPOP_SBC_1	279:283	PQSTS	SPOP	0.9473	More...
Q9NU22	Midasin	DEG_SPOP_SBC_1	1546:1550	PQSTS	SPOP	0.568	More...
Q9P2H0	Centrosomal protein of 126 kDa	DEG_SPOP_SBC_1	804:808	PQSTS	SPOP	0.9041	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_SPOP_SBC_1	502:506	PQSTS	SPOP	0.9849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons