DegronMD

Uniprot ID: Q9HCK1

Source protein: DBF4-type zinc finger-containing protein 2

Source gene: ZDBF2

Class: DEG_SPOP_SBC_1

Location: 502:506

E3 ligase: SPOP

DEGRON score: 0.9849

ASA_SCORE: 81.96

COIL: 0.9036

CONS_SCORE: 0.7821

DSS_SCORE: 0.6172

HELIX: 0.069

FCONS_SCORE: 1.0847

RIG_SCORE: 0.621

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T503S	AM-38	central_nervous_system	COSMIC	PQSTS	DEG_SPOP_SBC_1	0.7116
p.T505S	SIDM00492	Glioblastoma	GDSC	PQSTS	DEG_SPOP_SBC_1	0.6005
p.T505S	ACH-000269	Brain Cancer	CCLE	PQSTS	DEG_SPOP_SBC_1	0.6005
p.T505S	AM-38	central_nervous_system	COSMIC	PQSTS	DEG_SPOP_SBC_1	0.6005
p.D499N	TCGA-55-8302	LUAD	TCGA	PQSTS	DEG_SPOP_SBC_1	0.25
p.D499N	DO45312	LUAD	ICGC	PQSTS	DEG_SPOP_SBC_1	0.25
p.V513I	TCGA-43-A474	LUSC	TCGA	PQSTS	DEG_SPOP_SBC_1	0.1389
p.V513I	DO45490	LUSC	ICGC	PQSTS	DEG_SPOP_SBC_1	0.1389
p.E515D	TCGA-BR-8297	STAD	TCGA	PQSTS	DEG_SPOP_SBC_1	0.0833
p.E515D	DO38555	STAD	ICGC	PQSTS	DEG_SPOP_SBC_1	0.0833
p.E515K	TCGA-EE-A2M6	SKCM	TCGA	PQSTS	DEG_SPOP_SBC_1	0.0833
p.E515K	DO222514	MELA	ICGC	PQSTS	DEG_SPOP_SBC_1	0.0833
p.E515K	DO37976	SKCM	ICGC	PQSTS	DEG_SPOP_SBC_1	0.0833
p.E493K	TCGA-FW-A3R5	SKCM	TCGA	PQSTS	DEG_SPOP_SBC_1	0.0833
p.E493K	DO37406	SKCM	ICGC	PQSTS	DEG_SPOP_SBC_1	0.0833

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	1147:1151	PQSTS	SPOP	0.9731	More...
Q9P2H0	Centrosomal protein of 126 kDa	DEG_SPOP_SBC_1	804:808	PQSTS	SPOP	0.9041	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_SPOP_SBC_1	502:506	PQSTS	SPOP	0.9849	More...
Q96EP0	E3 ubiquitin-protein ligase RNF31	DEG_SPOP_SBC_1	279:283	PQSTS	SPOP	0.9473	More...
Q92817	Envoplakin	DEG_SPOP_SBC_1	1806:1810	PQSTS	SPOP	0.681	More...
Q14114	Low-density lipoprotein receptor-related protein 8	DEG_SPOP_SBC_1	738:742	PQSTS	SPOP	0.7494	More...
Q9NU22	Midasin	DEG_SPOP_SBC_1	1546:1550	PQSTS	SPOP	0.568	More...
P07202	Thyroid peroxidase	DEG_SPOP_SBC_1	245:249	PQSTS	SPOP	0.8902	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	1112:1116	PQSTS	SPOP	0.9975	More...

Showing 1 to 9 of 9 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons