DegronMD - Q14114(LRP8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L942F	TCGA-2W-A8YY	CESC	TCGA	PRSQLHQLP	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.2222
p.L942F	DO223732	CESC	ICGC	PRSQLHQLP	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.2222
p.V947A	TCGA-AJ-A3BH	UCEC	TCGA	PRSQLHQLP	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.0833
p.V947A	DO41638	UCEC	ICGC	PRSQLHQLP	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.0833
p.V948I	TCGA-AX-A3FT	UCEC	TCGA	PRSQLHQLP	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.0556
p.V948I	DO40801	UCEC	ICGC	PRSQLHQLP	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.0556
p.P927L	TCGA-B0-4698	KIRC	TCGA	PRSQLHQLP	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.25
p.P927L	DO233882	GACA	ICGC	PRSQLHQLP	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.25
p.P927L	DO20368	KIRC	ICGC	PRSQLHQLP	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.25
p.P927L	ACH-000488	Esophageal Cancer	CCLE	PRSQLHQLP	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.25
p.N940S	TCGA-BR-6452	STAD	TCGA	PRSQLHQLP	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.2778
p.N940S	DO35242	PACA	ICGC	PRSQLHQLP	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.2778
p.N940S	DO38404	STAD	ICGC	PRSQLHQLP	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.2778
p.S943F	TCGA-DD-AADS	LIHC	TCGA	PRSQLHQLP	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.1944
p.S943F	DO52247	LIHC	ICGC	PRSQLHQLP	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.1944
p.T749I	TCGA-DF-A2KU	UCEC	TCGA	PQSTS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.1389
p.T749I	DO223286	UCEC	ICGC	PQSTS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.1389
p.Q936K	DO229045	LICA	ICGC	PRSQLHQLP	DEG_APCC_DBOX_1	930:938	Mutation altering degron motif	0.5833
p.P927S	SIDM01307	Colorectal Carcinoma	GDSC	PRSQLHQLP	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.25
p.R736Q	SIDM00672	Hepatocellular Carcinoma	GDSC	PQSTS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.2778
p.L942I	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRSQLHQLP	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.2222
p.L942I	SLVL	haematopoietic and lymphoid tissue	COSMIC	PRSQLHQLP	DEG_APCC_DBOX_1	930:938	Mutation rewiring degron network	0.2222
p.E742D	ACH-000786	Lymphoma	CCLE	PQSTS	DEG_SPOP_SBC_1	738:742	Mutation altering degron motif	0.6758
p.E742D	Daudi	haematopoietic and lymphoid tissue	COSMIC	PQSTS	DEG_SPOP_SBC_1	738:742	Mutation altering degron motif	0.6758
p.P743L	RO82-W-1	thyroid	COSMIC	PQSTS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.3056
p.P743L	Daudi	haematopoietic and lymphoid tissue	COSMIC	PQSTS	DEG_SPOP_SBC_1	738:742	Mutation rewiring degron network	0.3056

Kaplan plot for LRP8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRP8

UniProt ID: Q14114

Entrez ID: 7804

Protein name: Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRP8 in