DegronMD

Uniprot ID: Q14114

Source protein: Low-density lipoprotein receptor-related protein 8

Source gene: LRP8

Class: DEG_APCC_DBOX_1

Location: 930:938

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8922

ASA_SCORE: 54.7333

COIL: 0.5102

CONS_SCORE: 0.4457

DSS_SCORE: 0.5161

HELIX: 0.0191

FCONS_SCORE: 0.9391

RIG_SCORE: 0.6737

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L942F	TCGA-2W-A8YY	CESC	TCGA	PRSQLHQLP	DEG_APCC_DBOX_1	0.2222
p.L942F	DO223732	CESC	ICGC	PRSQLHQLP	DEG_APCC_DBOX_1	0.2222
p.V947A	TCGA-AJ-A3BH	UCEC	TCGA	PRSQLHQLP	DEG_APCC_DBOX_1	0.0833
p.V947A	DO41638	UCEC	ICGC	PRSQLHQLP	DEG_APCC_DBOX_1	0.0833
p.V948I	TCGA-AX-A3FT	UCEC	TCGA	PRSQLHQLP	DEG_APCC_DBOX_1	0.0556
p.V948I	DO40801	UCEC	ICGC	PRSQLHQLP	DEG_APCC_DBOX_1	0.0556
p.P927L	TCGA-B0-4698	KIRC	TCGA	PRSQLHQLP	DEG_APCC_DBOX_1	0.25
p.P927L	DO233882	GACA	ICGC	PRSQLHQLP	DEG_APCC_DBOX_1	0.25
p.P927L	DO20368	KIRC	ICGC	PRSQLHQLP	DEG_APCC_DBOX_1	0.25
p.P927L	ACH-000488	Esophageal Cancer	CCLE	PRSQLHQLP	DEG_APCC_DBOX_1	0.25
p.N940S	TCGA-BR-6452	STAD	TCGA	PRSQLHQLP	DEG_APCC_DBOX_1	0.2778
p.N940S	DO35242	PACA	ICGC	PRSQLHQLP	DEG_APCC_DBOX_1	0.2778
p.N940S	DO38404	STAD	ICGC	PRSQLHQLP	DEG_APCC_DBOX_1	0.2778
p.S943F	TCGA-DD-AADS	LIHC	TCGA	PRSQLHQLP	DEG_APCC_DBOX_1	0.1944
p.S943F	DO52247	LIHC	ICGC	PRSQLHQLP	DEG_APCC_DBOX_1	0.1944
p.Q936K	DO229045	LICA	ICGC	PRSQLHQLP	DEG_APCC_DBOX_1	0.5833
p.P927S	SIDM01307	Colorectal Carcinoma	GDSC	PRSQLHQLP	DEG_APCC_DBOX_1	0.25
p.L942I	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRSQLHQLP	DEG_APCC_DBOX_1	0.2222
p.L942I	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	PRSQLHQLP	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14114	Low-density lipoprotein receptor-related protein 8	DEG_APCC_DBOX_1	930:938	PRSQLHQLP	APC,CDC20,FZR1	0.8922	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons