DegronMD - Q13428(TCOF1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K928T	TCGA-13-1404	OV	TCGA	DSGSSS	DEG_SCF_TRCP1_1	931:936	Mutation substituting flanking lysine	0.3611
p.K928T	DO28083	OV	ICGC	DSGSSS	DEG_SCF_TRCP1_1	931:936	Mutation substituting flanking lysine	0.3611
p.G1121R	TCGA-24-1104	OV	TCGA	PQSTS	DEG_SPOP_SBC_1	1112:1116	Mutation rewiring degron network	0.1944
p.A1166T	TCGA-85-7844	LUSC	TCGA	LGPTPSRT	DEG_SCF_FBW7_1	1172:1179	Mutation rewiring degron network	0.1667
p.M190I	TCGA-A3-3382	KIRC	TCGA	ADSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1667
p.A1103D	TCGA-A5-A1OF	UCEC	TCGA	PQSTS	DEG_SPOP_SBC_1	1112:1116	Mutation rewiring degron network	0.0833
p.A1103D	DO42568	UCEC	ICGC	PQSTS	DEG_SPOP_SBC_1	1112:1116	Mutation rewiring degron network	0.0833
p.Y1206D	TCGA-AG-A002	READ	TCGA	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation blocking phosphorylation signal	0.75
p.P566Q	TCGA-BF-A1PV	SKCM	TCGA	ESSDSSDGEVPTA	DEG_COP1_1	551:563	Mutation rewiring degron network	0.25
p.P566Q	DO47309	SKCM	ICGC	ESSDSSDGEVPTA	DEG_COP1_1	551:563	Mutation rewiring degron network	0.25
p.E543K	TCGA-C5-A7X5	CESC	TCGA	ESSDSSDGEVPTA	DEG_COP1_1	551:563	Mutation rewiring degron network	0.1111
p.E543K	DO49894	CESC	ICGC	ESSDSSDGEVPTA	DEG_COP1_1	551:563	Mutation rewiring degron network	0.1111
p.E551K	TCGA-C5-A7X5	CESC	TCGA	ESSDSSDGEVPTA	DEG_COP1_1	551:563	Mutation altering degron motif	0.7022
p.E551K	DO49894	CESC	ICGC	ESSDSSDGEVPTA	DEG_COP1_1	551:563	Mutation altering degron motif	0.7022
p.S206C	TCGA-C5-A8XJ	CESC	TCGA	ADSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1667
p.S206C	DO49902	CESC	ICGC	ADSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1667
p.R77L	TCGA-CJ-4899	KIRC	TCGA	PISTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.2222
p.R77L	DO16233	KIRC	ICGC	PISTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.2222
p.G943R	TCGA-D1-A17M	UCEC	TCGA	DSGSSS	DEG_SCF_TRCP1_1	931:936	Mutation rewiring degron network	0.1389
p.G943R	DO43779	UCEC	ICGC	DSGSSS	DEG_SCF_TRCP1_1	931:936	Mutation rewiring degron network	0.1389
p.Q1164H	TCGA-D1-A2G0	UCEC	TCGA	LGPTPSRT	DEG_SCF_FBW7_1	1172:1179	Mutation rewiring degron network	0.1111
p.P1176S	TCGA-D6-6516	HNSC	TCGA	LGPTPSRT	DEG_SCF_FBW7_1	1172:1179	Mutation altering degron motif	0.6752
p.P1176S	TCGA-EB-A431	SKCM	TCGA	LGPTPSRT	DEG_SCF_FBW7_1	1172:1179	Mutation altering degron motif	0.6752
p.P1176S	TCGA-FS-A4F5	SKCM	TCGA	LGPTPSRT	DEG_SCF_FBW7_1	1172:1179	Mutation altering degron motif	0.6752
p.P1108S	TCGA-D9-A1JX	SKCM	TCGA	PQSTS	DEG_SPOP_SBC_1	1112:1116	Mutation rewiring degron network	0.2222
p.P1108S	DO37711	SKCM	ICGC	PQSTS	DEG_SPOP_SBC_1	1112:1116	Mutation rewiring degron network	0.2222
p.S192L	TCGA-DU-6392	LGG	TCGA	ADSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.2222
p.S192L	DO22237	LGG	ICGC	ADSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.2222
p.R77C	TCGA-E6-A1LX	UCEC	TCGA	PISTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.2222
p.R77C	DO42304	UCEC	ICGC	PISTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.2222
p.R77C	DO41020	UCEC	ICGC	PISTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.2222
p.E937K	TCGA-EE-A180	SKCM	TCGA	DSGSSS	DEG_SCF_TRCP1_1	931:936	Mutation rewiring degron network	0.3056
p.E937K	DO47537	SKCM	ICGC	DSGSSS	DEG_SCF_TRCP1_1	931:936	Mutation rewiring degron network	0.3056
p.S990L	TCGA-EE-A29T	SKCM	TCGA	ARSSS	DEG_SPOP_SBC_1	994:998	Mutation rewiring degron network	0.2222
p.E89K	TCGA-EE-A2A1	SKCM	TCGA	PISTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.2222
p.E89K	DO38045	SKCM	ICGC	PISTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.2222
p.S1199F	TCGA-EE-A2MS	SKCM	TCGA	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation blocking phosphorylation signal	0.5556
p.G573W	TCGA-EO-A3KX	UCEC	TCGA	ESSDSSDGEVPTA	DEG_COP1_1	551:563	Mutation rewiring degron network	0.0556
p.G573W	DO219774	UCEC	ICGC	ESSDSSDGEVPTA	DEG_COP1_1	551:563	Mutation rewiring degron network	0.0556
p.G1121W	TCGA-FS-A1Z0	SKCM	TCGA	PQSTS	DEG_SPOP_SBC_1	1112:1116	Mutation rewiring degron network	0.1944
p.A1119V	TCGA-GN-A26C	SKCM	TCGA	PQSTS	DEG_SPOP_SBC_1	1112:1116	Mutation rewiring degron network	0.25
p.R995S	TCGA-IR-A3LK	CESC	TCGA	ARSSS	DEG_SPOP_SBC_1	994:998	Mutation altering degron motif	0.6316
p.R995S	DO44299	CESC	ICGC	ARSSS	DEG_SPOP_SBC_1	994:998	Mutation altering degron motif	0.6316
p.E1004K	TCGA-IR-A3LK	CESC	TCGA	ARSSS	DEG_SPOP_SBC_1	994:998	Mutation rewiring degron network	0.1667
p.E546Q	TCGA-MV-A51V	BLCA	TCGA	ESSDSSDGEVPTA	DEG_COP1_1	551:563	Mutation rewiring degron network	0.1944
p.E546Q	DO474	BLCA	ICGC	ESSDSSDGEVPTA	DEG_COP1_1	551:563	Mutation rewiring degron network	0.1944
p.S552L	TCGA-VQ-A8PO	STAD	TCGA	ESSDSSDGEVPTA	DEG_COP1_1	551:563	Mutation altering degron motif	0.7667
p.S552L	DO51773	STAD	ICGC	ESSDSSDGEVPTA	DEG_COP1_1	551:563	Mutation altering degron motif	0.7667
p.S207R	TCGA-W3-AA1R	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1389
p.S207R	DO51275	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1389
p.E91K	DO227916	BRCA	ICGC	PISTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.1667
p.A1199V	DO2186	BRCA	ICGC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation blocking phosphorylation signal	0.5556
p.S922L	DO222919	BTCA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	931:936	Mutation rewiring degron network	0.0833
p.E927K	DO44299	CESC	ICGC	DSGSSS	DEG_SCF_TRCP1_1	931:936	Mutation rewiring degron network	0.2222
p.A1200T	DO230312	COCA	ICGC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation rewiring degron network	0.1389
p.S88L	DO222762	COCA	ICGC	PISTS	DEG_SPOP_SBC_1	81:85	Mutation blocking phosphorylation signal	0.6944
p.D1005N	DO234170	ESAD	ICGC	ARSSS	DEG_SPOP_SBC_1	994:998	Mutation rewiring degron network	0.1389
p.P921S	DO11854	GBM	ICGC	DSGSSS	DEG_SCF_TRCP1_1	931:936	Mutation rewiring degron network	0.0556
p.A926S	DO228377	LICA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	931:936	Mutation rewiring degron network	0.1944
p.V191L	DO228985	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1944
p.S198I	DO229019	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	196:200	Mutation altering degron motif	0.7341
p.V78L	DO229015	LICA	ICGC	PISTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.25
p.D1110Y	DO229027	LICA	ICGC	PQSTS	DEG_SPOP_SBC_1	1112:1116	Mutation blocking phosphorylation signal	0.7222
p.S1104I	DO229026	LICA	ICGC	PQSTS	DEG_SPOP_SBC_1	1112:1116	Mutation rewiring degron network	0.1111
p.S1114I	DO229045	LICA	ICGC	PQSTS	DEG_SPOP_SBC_1	1112:1116	Mutation altering degron motif	0.8453
p.D1205H	DO50828	LICA	ICGC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation rewiring degron network	0.2778
p.P1177R	DO230550	LUSC	ICGC	LGPTPSRT	DEG_SCF_FBW7_1	1172:1179	Mutation altering degron motif	0.7512
p.T76P	DO228253	MALY	ICGC	PISTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.1944
p.A1199T	DO227546	PBCA	ICGC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation blocking phosphorylation signal	0.5556
p.S1162F	DO37567	SKCM	ICGC	LGPTPSRT	DEG_SCF_FBW7_1	1172:1179	Mutation rewiring degron network	0.0556
p.P1221H	DO47491	SKCM	ICGC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation rewiring degron network	0.0833
p.A1213V	DO38328	STAD	ICGC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation rewiring degron network	0.3056
p.Q1126H	DO43049	UCEC	ICGC	PQSTS	DEG_SPOP_SBC_1	1112:1116	Mutation rewiring degron network	0.0556
p.R988Q	SIDM01313	Colorectal Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	994:998	Mutation rewiring degron network	0.1667
p.S992N	SIDM01652	Non-Cancerous	GDSC	ARSSS	DEG_SPOP_SBC_1	994:998	Mutation rewiring degron network	0.2778
p.S992N	SIDM00187	Kidney Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	994:998	Mutation rewiring degron network	0.2778
p.S992N	ACH-002352	Non-Cancerous	CCLE	ARSSS	DEG_SPOP_SBC_1	994:998	Mutation rewiring degron network	0.2778
p.T1171M	SIDM00602	Gastric Carcinoma	GDSC	LGPTPSRT	DEG_SCF_FBW7_1	1172:1179	Mutation blocking phosphorylation signal	0.75
p.T1171M	IM-95	stomach	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	1172:1179	Mutation blocking phosphorylation signal	0.75
p.S85L	SIDM00040	Gastric Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	81:85	Mutation altering degron motif	0.8778
p.S85L	ACH-002202	Gastric Cancer	CCLE	PISTS	DEG_SPOP_SBC_1	81:85	Mutation altering degron motif	0.8778
p.S85L	TMK-1	stomach	COSMIC	PISTS	DEG_SPOP_SBC_1	81:85	Mutation altering degron motif	0.8778
p.T1212I	SIDM00854	Burkitt's Lymphoma	GDSC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation altering degron motif	0.7078
p.T1212I	GA-10	haematopoietic and lymphoid tissue	COSMIC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation altering degron motif	0.7078
p.S941N	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	931:936	Mutation blocking phosphorylation signal	0.6389
p.S941N	ACH-000305	Esophageal Cancer	CCLE	DSGSSS	DEG_SCF_TRCP1_1	931:936	Mutation blocking phosphorylation signal	0.6389
p.S941N	EC-GI-10	oesophagus	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	931:936	Mutation blocking phosphorylation signal	0.6389
p.M1207K	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation altering degron motif	0.8062
p.M1207K	SIDM00826	Colorectal Carcinoma	GDSC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation altering degron motif	0.8062
p.M1207K	SIDM00823	Colorectal Carcinoma	GDSC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation altering degron motif	0.8062
p.R77H	SIDM00819	Kidney Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.2222
p.R77H	ACH-002189	Kidney Cancer	CCLE	PISTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.2222
p.R77H	RCC-FG2	kidney	COSMIC	PISTS	DEG_SPOP_SBC_1	81:85	Mutation rewiring degron network	0.2222
p.S1201F	SIDM00532	Glioma	GDSC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation rewiring degron network	0.1667
p.S1201F	MOG-G-CCM	central nervous system	COSMIC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation rewiring degron network	0.1667
p.P921L	SIDM00863	Burkitt's Lymphoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	931:936	Mutation rewiring degron network	0.0556
p.T1175I	ACH-000162	Lymphoma	CCLE	LGPTPSRT	DEG_SCF_FBW7_1	1172:1179	Mutation altering degron motif	0.8189
p.T1175I	GA-10	haematopoietic and lymphoid tissue	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	1172:1179	Mutation altering degron motif	0.8189
p.Q1214R	ACH-000427	Gastric Cancer	CCLE	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation rewiring degron network	0.2778
p.Q1214R	NCI-N87	stomach	COSMIC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation rewiring degron network	0.2778
p.L1219F	ACH-000679	Esophageal Cancer	CCLE	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation rewiring degron network	0.1389
p.L1219F	OE19	oesophagus	COSMIC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation rewiring degron network	0.1389
p.L1198P	ACH-000998	Colon/Colorectal Cancer	CCLE	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation rewiring degron network	0.0833
p.L1198P	CW-2	large intestine	COSMIC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation rewiring degron network	0.0833
p.D1202E	ACH-001081	Colon/Colorectal Cancer	CCLE	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation rewiring degron network	0.1944
p.D1202E	HCC2998	large intestine	COSMIC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation rewiring degron network	0.1944
p.S1164F	MOG-G-CCM	central nervous system	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	1172:1179	Mutation rewiring degron network	0.1111
p.R941I	NCC021	kidney	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	931:936	Mutation blocking phosphorylation signal	0.6389
p.T1213I	GA-10	haematopoietic and lymphoid tissue	COSMIC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation rewiring degron network	0.3056
p.N572D	NCI-H740	lung	COSMIC	ESSDSSDGEVPTA	DEG_COP1_1	551:563	Mutation rewiring degron network	0.0833
p.S1163F	MOG-G-CCM	central nervous system	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	1172:1179	Mutation rewiring degron network	0.0833
p.D1162E	HCC2998	large intestine	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	1172:1179	Mutation rewiring degron network	0.0556
p.Q1213R	NCI-N87	stomach	COSMIC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation rewiring degron network	0.3056
p.L1179F	OE19	oesophagus	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	1172:1179	Mutation altering degron motif	0.6981
p.T551I	TOV-21G	ovary	COSMIC	ESSDSSDGEVPTA	DEG_COP1_1	551:563	Mutation altering degron motif	0.7078
p.D1201E	HCC2998	large intestine	COSMIC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation rewiring degron network	0.1667
p.Q1175R	NCI-N87	stomach	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	1172:1179	Mutation altering degron motif	0.7329
p.D1163E	HCC2998	large intestine	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	1172:1179	Mutation rewiring degron network	0.0833
p.L1197P	CW-2	large intestine	COSMIC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation rewiring degron network	0.0556
p.Q1174R	NCI-N87	stomach	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	1172:1179	Mutation altering degron motif	0.7329
p.L1180F	OE19	oesophagus	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	1172:1179	Mutation rewiring degron network	0.3056
p.A548P	NCI-H2122	lung	COSMIC	ESSDSSDGEVPTA	DEG_COP1_1	551:563	Mutation rewiring degron network	0.25
p.T1170M	IM-95	stomach	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	1172:1179	Mutation rewiring degron network	0.2778
p.S1124F	MOG-G-CCM	central nervous system	COSMIC	PQSTS	DEG_SPOP_SBC_1	1112:1116	Mutation substituting flanking lysine	0.2222
p.S1125F	MOG-G-CCM	central nervous system	COSMIC	PQSTS	DEG_SPOP_SBC_1	1112:1116	Mutation rewiring degron network	0.0833
p.L1218F	OE19	oesophagus	COSMIC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation rewiring degron network	0.1667
p.S1202F	MOG-G-CCM	central nervous system	COSMIC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation rewiring degron network	0.1944
p.Q1209R	CW-2	large intestine	COSMIC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation altering degron motif	0.7329
p.T1174I	GA-10	haematopoietic and lymphoid tissue	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	1172:1179	Mutation altering degron motif	0.7078
p.Q1208R	CW-2	large intestine	COSMIC	MTPGLT	DEG_SCF_FBW7_1	1207:1212	Mutation altering degron motif	0.7329
p.V999I	SNU-1040	large intestine	COSMIC	ARSSS	DEG_SPOP_SBC_1	994:998	Mutation blocking phosphorylation signal	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TCOF1

UniProt ID: Q13428

Entrez ID: 6949

Protein name: Treacle protein (Treacher Collins syndrome protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TCOF1 in