DegronMD

Uniprot ID: Q13428

Source protein: Treacle protein

Source gene: TCOF1

Class: DEG_COP1_1

Location: 551:563

E3 ligase: COP1

DEGRON score: 0.9956

ASA_SCORE: 92.6615

COIL: 0.9478

CONS_SCORE: 0.3716

DSS_SCORE: 0.788

HELIX: 0.0303

FCONS_SCORE: 1.0839

RIG_SCORE: 0.5715

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P566Q	TCGA-BF-A1PV	SKCM	TCGA	ESSDSSDGEVPTA	DEG_COP1_1	0.25
p.P566Q	DO47309	SKCM	ICGC	ESSDSSDGEVPTA	DEG_COP1_1	0.25
p.E543K	TCGA-C5-A7X5	CESC	TCGA	ESSDSSDGEVPTA	DEG_COP1_1	0.1111
p.E543K	DO49894	CESC	ICGC	ESSDSSDGEVPTA	DEG_COP1_1	0.1111
p.E551K	TCGA-C5-A7X5	CESC	TCGA	ESSDSSDGEVPTA	DEG_COP1_1	0.7022
p.E551K	DO49894	CESC	ICGC	ESSDSSDGEVPTA	DEG_COP1_1	0.7022
p.G573W	TCGA-EO-A3KX	UCEC	TCGA	ESSDSSDGEVPTA	DEG_COP1_1	0.0556
p.G573W	DO219774	UCEC	ICGC	ESSDSSDGEVPTA	DEG_COP1_1	0.0556
p.E546Q	TCGA-MV-A51V	BLCA	TCGA	ESSDSSDGEVPTA	DEG_COP1_1	0.1944
p.E546Q	DO474	BLCA	ICGC	ESSDSSDGEVPTA	DEG_COP1_1	0.1944
p.S552L	TCGA-VQ-A8PO	STAD	TCGA	ESSDSSDGEVPTA	DEG_COP1_1	0.7667
p.S552L	DO51773	STAD	ICGC	ESSDSSDGEVPTA	DEG_COP1_1	0.7667
p.N572D	NCI-H740	lung	COSMIC	ESSDSSDGEVPTA	DEG_COP1_1	0.0833
p.T551I	TOV-21G	ovary	COSMIC	ESSDSSDGEVPTA	DEG_COP1_1	0.7078
p.A548P	NCI-H2122	lung	COSMIC	ESSDSSDGEVPTA	DEG_COP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13428	Treacle protein	DEG_COP1_1	551:563	ESSDSSDGEVPTA	COP1	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons