DegronMD

Uniprot ID: Q13428

Source protein: Treacle protein

Source gene: TCOF1

Class: DEG_SCF_TRCP1_1

Location: 931:936

E3 ligase: BTRC

DEGRON score: 0.9956

ASA_SCORE: 81.6

COIL: 0.9587

CONS_SCORE: 0.394

DSS_SCORE: 0.858

HELIX: 0.0293

FCONS_SCORE: 0.9831

RIG_SCORE: 0.4905

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K928T	TCGA-13-1404	OV	TCGA	DSGSSS	DEG_SCF_TRCP1_1	0.3611
p.K928T	DO28083	OV	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.3611
p.G943R	TCGA-D1-A17M	UCEC	TCGA	DSGSSS	DEG_SCF_TRCP1_1	0.1389
p.G943R	DO43779	UCEC	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.1389
p.E937K	TCGA-EE-A180	SKCM	TCGA	DSGSSS	DEG_SCF_TRCP1_1	0.3056
p.E937K	DO47537	SKCM	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.3056
p.S922L	DO222919	BTCA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.0833
p.E927K	DO44299	CESC	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.2222
p.P921S	DO11854	GBM	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.0556
p.A926S	DO228377	LICA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.1944
p.S941N	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.6389
p.S941N	ACH-000305	Esophageal Cancer	CCLE	DSGSSS	DEG_SCF_TRCP1_1	0.6389
p.S941N	EC-GI-10	oesophagus	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	0.6389
p.P921L	SIDM00863	Burkitt's Lymphoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.0556
p.R941I	NCC021	kidney	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13428	Treacle protein	DEG_SCF_TRCP1_1	931:936	DSGSSS	BTRC	0.9956	More...
Q8IYG6	Leucine-rich repeat-containing protein 56	DEG_SCF_TRCP1_1	460:465	DSGSSS	BTRC	0.9835	More...
Q96S38	Ribosomal protein S6 kinase delta-1	DEG_SCF_TRCP1_1	499:504	DSGSSS	BTRC	0.9876	More...
Q9C0H9	SRC kinase signaling inhibitor 1	DEG_SCF_TRCP1_1	512:517	DSGSSS	BTRC	0.9672	More...
Q9H7S9	Zinc finger protein 703	DEG_SCF_TRCP1_1	169:174	DSGSSS	BTRC	0.9995	More...
Q9NQ76	Matrix extracellular phosphoglycoprotein	DEG_SCF_TRCP1_1	515:520	DSGSSS	BTRC	0.9943	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SCF_TRCP1_1	53:58	DSGSSS	BTRC	0.9394	More...
Q9C0H5	Rho GTPase-activating protein 39	DEG_SCF_TRCP1_1	168:173	DSGSSS	BTRC	0.9988	More...
Q86VQ1	Glucocorticoid-induced transcript 1 protein	DEG_SCF_TRCP1_1	393:398	DSGSSS	BTRC	0.9577	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons