DegronMD - Q96S38(RPS6KC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D852N	TCGA-50-5935	LUAD	TCGA	VLLFTD	LIG_APCC_ABBA_1	843:848	Mutation rewiring degron network	0.2222
p.D836N	TCGA-A5-A1OF	UCEC	TCGA	VLLFTD	LIG_APCC_ABBA_1	843:848	Mutation rewiring degron network	0.1389
p.S504A	TCGA-AA-3977	COAD	TCGA	DSGSSS	DEG_SCF_TRCP1_1	499:504	Mutation altering degron motif	0.7588
p.S493I	TCGA-AX-A05Z	UCEC	TCGA	DSGSSS	DEG_SCF_TRCP1_1	499:504	Mutation rewiring degron network	0.1667
p.D851N	TCGA-DK-A1A3	BLCA	TCGA	VLLFTD	LIG_APCC_ABBA_1	843:848	Mutation rewiring degron network	0.25
p.S500C	TCGA-GC-A3RB	BLCA	TCGA	DSGSSS	DEG_SCF_TRCP1_1	499:504	Mutation altering degron motif	0.8652
p.P498R	DO217788	BRCA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	499:504	Mutation rewiring degron network	0.3056
p.D848Y	DO230529	LUSC	ICGC	VLLFTD	LIG_APCC_ABBA_1	843:848	Mutation altering degron motif	0.7325
p.W849C	DO219193	LUSC	ICGC	VLLFTD	LIG_APCC_ABBA_1	843:848	Mutation rewiring degron network	0.3056
p.P842L	DO222423	MELA	ICGC	VLLFTD	LIG_APCC_ABBA_1	843:848	Mutation rewiring degron network	0.3056
p.P842L	DO222546	MELA	ICGC	VLLFTD	LIG_APCC_ABBA_1	843:848	Mutation rewiring degron network	0.3056
p.P842L	DO37425	SKCM	ICGC	VLLFTD	LIG_APCC_ABBA_1	843:848	Mutation rewiring degron network	0.3056
p.H841Q	DO51288	SKCM	ICGC	VLLFTD	LIG_APCC_ABBA_1	843:848	Mutation rewiring degron network	0.2778
p.M853I	DO51281	SKCM	ICGC	VLLFTD	LIG_APCC_ABBA_1	843:848	Mutation rewiring degron network	0.1944
p.R854K	DO40884	UCEC	ICGC	VLLFTD	LIG_APCC_ABBA_1	843:848	Mutation rewiring degron network	0.1667
p.D837Y	DO41758	UCEC	ICGC	VLLFTD	LIG_APCC_ABBA_1	843:848	Mutation rewiring degron network	0.1667
p.D837Y	DO41572	UCEC	ICGC	VLLFTD	LIG_APCC_ABBA_1	843:848	Mutation rewiring degron network	0.1667
p.T499I	DO42608	UCEC	ICGC	DSGSSS	DEG_SCF_TRCP1_1	499:504	Mutation altering degron motif	0.7078
p.A850T	DO41235	UCEC	ICGC	VLLFTD	LIG_APCC_ABBA_1	843:848	Mutation rewiring degron network	0.2778
p.S840Y	DO42793	UCEC	ICGC	VLLFTD	LIG_APCC_ABBA_1	843:848	Mutation rewiring degron network	0.25
p.K512R	DO42793	UCEC	ICGC	DSGSSS	DEG_SCF_TRCP1_1	499:504	Mutation rewiring degron network	0.1111
p.E506A	SIDM00614	Hepatocellular Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	499:504	Mutation rewiring degron network	0.2778
p.E506A	JHH-7	liver	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	499:504	Mutation rewiring degron network	0.2778
p.C508F	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	499:504	Mutation rewiring degron network	0.2222
p.C508F	ACH-000282	Lung Cancer	CCLE	DSGSSS	DEG_SCF_TRCP1_1	499:504	Mutation rewiring degron network	0.2222
p.C508F	NCI-H1755	lung	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	499:504	Mutation rewiring degron network	0.2222
p.Q837H	ACH-000829	Myeloma	CCLE	VLLFTD	LIG_APCC_ABBA_1	843:848	Mutation rewiring degron network	0.1667
p.E494A	ACH-000848	Liver Cancer	CCLE	DSGSSS	DEG_SCF_TRCP1_1	499:504	Mutation rewiring degron network	0.1944
p.E494A	JHH-7	liver	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	499:504	Mutation rewiring degron network	0.1944
p.L503S	ACH-002256	Leukemia	CCLE	DSGSSS	DEG_SCF_TRCP1_1	499:504	Mutation altering degron motif	0.7667
p.L503S	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	499:504	Mutation altering degron motif	0.7667
p.D494Y	GI-ME-N	autonomic ganglia	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	499:504	Mutation rewiring degron network	0.1944
p.I498V	Daudi	haematopoietic and lymphoid tissue	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	499:504	Mutation rewiring degron network	0.3056
p.S491L	ZR-75-30	breast	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	499:504	Mutation rewiring degron network	0.1111
p.E841K	HCC2218	breast	COSMIC	VLLFTD	LIG_APCC_ABBA_1	843:848	Mutation rewiring degron network	0.2778
p.C496F	NCI-H1755	lung	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	499:504	Mutation substituting flanking lysine	0.3611
p.R844H	HCT-116	large intestine	COSMIC	VLLFTD	LIG_APCC_ABBA_1	843:848	Mutation altering degron motif	0.8244
p.I508M	TOV-21G	ovary	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	499:504	Mutation rewiring degron network	0.2222
p.E499A	Daudi	haematopoietic and lymphoid tissue	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	499:504	Mutation altering degron motif	0.7701

Kaplan plot for RPS6KC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RPS6KC1

UniProt ID: Q96S38

Entrez ID: 26750

Protein name: Ribosomal protein S6 kinase delta-1 (S6K-delta-1) (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RPS6KC1 in