DegronMD

Uniprot ID: Q96S38

Source protein: Ribosomal protein S6 kinase delta-1

Source gene: RPS6KC1

Class: LIG_APCC_ABBA_1

Location: 843:848

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8284

ASA_SCORE: 76.3

COIL: 0.3055

CONS_SCORE: 0.3406

DSS_SCORE: 0.411

HELIX: 0.6477

FCONS_SCORE: 1.0644

RIG_SCORE: 0.868

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D852N	TCGA-50-5935	LUAD	TCGA	VLLFTD	LIG_APCC_ABBA_1	0.2222
p.D836N	TCGA-A5-A1OF	UCEC	TCGA	VLLFTD	LIG_APCC_ABBA_1	0.1389
p.D851N	TCGA-DK-A1A3	BLCA	TCGA	VLLFTD	LIG_APCC_ABBA_1	0.25
p.D848Y	DO230529	LUSC	ICGC	VLLFTD	LIG_APCC_ABBA_1	0.7325
p.W849C	DO219193	LUSC	ICGC	VLLFTD	LIG_APCC_ABBA_1	0.3056
p.P842L	DO222423	MELA	ICGC	VLLFTD	LIG_APCC_ABBA_1	0.3056
p.P842L	DO222546	MELA	ICGC	VLLFTD	LIG_APCC_ABBA_1	0.3056
p.P842L	DO37425	SKCM	ICGC	VLLFTD	LIG_APCC_ABBA_1	0.3056
p.H841Q	DO51288	SKCM	ICGC	VLLFTD	LIG_APCC_ABBA_1	0.2778
p.M853I	DO51281	SKCM	ICGC	VLLFTD	LIG_APCC_ABBA_1	0.1944
p.R854K	DO40884	UCEC	ICGC	VLLFTD	LIG_APCC_ABBA_1	0.1667
p.D837Y	DO41758	UCEC	ICGC	VLLFTD	LIG_APCC_ABBA_1	0.1667
p.D837Y	DO41572	UCEC	ICGC	VLLFTD	LIG_APCC_ABBA_1	0.1667
p.A850T	DO41235	UCEC	ICGC	VLLFTD	LIG_APCC_ABBA_1	0.2778
p.S840Y	DO42793	UCEC	ICGC	VLLFTD	LIG_APCC_ABBA_1	0.25
p.Q837H	ACH-000829	Myeloma	CCLE	VLLFTD	LIG_APCC_ABBA_1	0.1667
p.E841K	HCC2218	breast	COSMIC	VLLFTD	LIG_APCC_ABBA_1	0.2778
p.R844H	HCT-116	large_intestine	COSMIC	VLLFTD	LIG_APCC_ABBA_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96S38	Ribosomal protein S6 kinase delta-1	LIG_APCC_ABBA_1	843:848	VLLFTD	APC,CDC20,FZR1	0.8284	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons