DegronMD

Uniprot ID: Q96S38

Source protein: Ribosomal protein S6 kinase delta-1

Source gene: RPS6KC1

Class: DEG_SCF_TRCP1_1

Location: 499:504

E3 ligase: BTRC

DEGRON score: 0.9876

ASA_SCORE: 68.5667

COIL: 0.8503

CONS_SCORE: 0.4078

DSS_SCORE: 0.6834

HELIX: 0.0907

FCONS_SCORE: 1.0292

RIG_SCORE: 0.5287

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S504A	TCGA-AA-3977	COAD	TCGA	DSGSSS	DEG_SCF_TRCP1_1	0.7588
p.S493I	TCGA-AX-A05Z	UCEC	TCGA	DSGSSS	DEG_SCF_TRCP1_1	0.1667
p.S500C	TCGA-GC-A3RB	BLCA	TCGA	DSGSSS	DEG_SCF_TRCP1_1	0.8652
p.P498R	DO217788	BRCA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.3056
p.T499I	DO42608	UCEC	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.7078
p.K512R	DO42793	UCEC	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.1111
p.E506A	SIDM00614	Hepatocellular Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.2778
p.E506A	JHH-7	liver	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	0.2778
p.C508F	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.2222
p.C508F	ACH-000282	Lung Cancer	CCLE	DSGSSS	DEG_SCF_TRCP1_1	0.2222
p.C508F	NCI-H1755	lung	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	0.2222
p.E494A	ACH-000848	Liver Cancer	CCLE	DSGSSS	DEG_SCF_TRCP1_1	0.1944
p.E494A	JHH-7	liver	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	0.1944
p.L503S	ACH-002256	Leukemia	CCLE	DSGSSS	DEG_SCF_TRCP1_1	0.7667
p.L503S	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	0.7667
p.D494Y	GI-ME-N	autonomic_ganglia	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	0.1944
p.I498V	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	0.3056
p.S491L	ZR-75-30	breast	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	0.1111
p.C496F	NCI-H1755	lung	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	0.3611
p.I508M	TOV-21G	ovary	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	0.2222
p.E499A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	0.7701

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13428	Treacle protein	DEG_SCF_TRCP1_1	931:936	DSGSSS	BTRC	0.9956	More...
Q8IYG6	Leucine-rich repeat-containing protein 56	DEG_SCF_TRCP1_1	460:465	DSGSSS	BTRC	0.9835	More...
Q96S38	Ribosomal protein S6 kinase delta-1	DEG_SCF_TRCP1_1	499:504	DSGSSS	BTRC	0.9876	More...
Q9C0H9	SRC kinase signaling inhibitor 1	DEG_SCF_TRCP1_1	512:517	DSGSSS	BTRC	0.9672	More...
Q9H7S9	Zinc finger protein 703	DEG_SCF_TRCP1_1	169:174	DSGSSS	BTRC	0.9995	More...
Q9NQ76	Matrix extracellular phosphoglycoprotein	DEG_SCF_TRCP1_1	515:520	DSGSSS	BTRC	0.9943	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SCF_TRCP1_1	53:58	DSGSSS	BTRC	0.9394	More...
Q9C0H5	Rho GTPase-activating protein 39	DEG_SCF_TRCP1_1	168:173	DSGSSS	BTRC	0.9988	More...
Q86VQ1	Glucocorticoid-induced transcript 1 protein	DEG_SCF_TRCP1_1	393:398	DSGSSS	BTRC	0.9577	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons